Mitochondrial Ca2+ Uniporter Blockers Influence Activation-Induced CBF Response in the Rat Somatosensory Cortex

Effects of mitochondrial calcium signaling blockade on neural activation-induced CBF response were studied in urethane-anesthetized rats. Ruthenium red (RuR), a nonspecific inhibitor of the mitochondrial calcium uniporter (MCU), and Ru360, a highly specific inhibitor of the MCU, were delivered intra...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2008-04, Vol.28 (4), p.772-785
Hauptverfasser:	Kannurpatti, Sridhar S, Biswal, Bharat B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium Channels - drug effects Calcium Channels - metabolism Cell Respiration - physiology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Fundamental and applied biological sciences. Psychology Image Processing, Computer-Assisted Injections, Intravenous Injections, Intraventricular Laser-Doppler Flowmetry Medical sciences Neurology Neurons - drug effects Neurons - metabolism Rats Rats, Sprague-Dawley Ruthenium Compounds - administration & dosage Ruthenium Red - administration & dosage Somatosensory Cortex - blood supply Somatosensory Cortex - metabolism Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs Vibrissae - innervation
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