Antioxidant Enzymes and Diabetic Retinopathy
: The aim of this study was to discuss the serum copper (Cu), zinc (Zn), nitric oxide (NO), glutathione (GSH), advanced oxidation protein products (AOPP) levels, and superoxide dismutase (SOD) activities with diabetic retinopathy severity. Twenty‐five patients with proliferative diabetic retinopath...
Gespeichert in:
| Veröffentlicht in: | Annals of the New York Academy of Sciences 2007-04, Vol.1100 (1), p.199-206 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 206 |
|---|---|
| container_issue | 1 |
| container_start_page | 199 |
| container_title | Annals of the New York Academy of Sciences |
| container_volume | 1100 |
| creator | YILDIRIM, ZUHAL UÇGUN, N. IREM KILIÇ, NEDRET GÜRSEL, E. SEPICI-DINÇEL, AYLIN |
| description | : The aim of this study was to discuss the serum copper (Cu), zinc (Zn), nitric oxide (NO), glutathione (GSH), advanced oxidation protein products (AOPP) levels, and superoxide dismutase (SOD) activities with diabetic retinopathy severity. Twenty‐five patients with proliferative diabetic retinopathy (PDR group 1), 25 patients with nonproliferative diabetic retinopathy (NPDR group 2), and 25 nondiabetic controls (control group) were included in the study. Patients who had macrovascular complications of diabetes (coronary arterial disease, periferic vascular disease) were excluded. The major finding of our study was that we did not observe any differences between group 1 and 2, which we aimed to discuss the severity of diabetic retinopathy. As the levels of SOD and Zn were not different between the groups, statistically significant differences were observed for GSH, NO, and Cu levels when compared to control group. AOPP levels were statistically increased in group 1 compared to control group. It can be suggested that hyperglycemia in DM is associated with accelerated nonenzymatic glycation and oxidative stress. |
| doi_str_mv | 10.1196/annals.1395.019 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70431148</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70431148</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3779-7cadd68fe9225ddccdb90238dd305438727f98c650148613c3bd7ca6c03f25213</originalsourceid><addsrcrecordid>eNqFkD1PwzAYBi0EoqUws6FMTKT1R2LHYwWlIJUioAjBYjm2IwKJU-JUNPx6XFLByOJ3uXssHQDHCA4R4nQkrZWFGyLC4yFEfAf0EYt4SCnBu6APIWNhwjHpgQPn3iBEOInYPuh5iELEeB-cjW2TV-tcS9sEE_vVlsYF0urgIpepaXIV3PvXVkvZvLaHYC_z35mj7R2Ax8vJ4vwqnN1Or8_Hs1ARxnjIlNSaJpnhGMdaK6VTDjFJtCYwjkjCMMt4omgMUZRQRBRJtXeogiTDMUZkAE673WVdfayMa0SZO2WKQlpTrZxgMCLIux4cdaCqK-dqk4llnZeybgWCYhNIdIHEJpDwgbxxsp1epaXRf_y2iAdIB3zmhWn_2xPz5_HDz2zYWblrzPrXkvW7oIywWDzNp2KWvDB4RxfihnwDk7-A8w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70431148</pqid></control><display><type>article</type><title>Antioxidant Enzymes and Diabetic Retinopathy</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>YILDIRIM, ZUHAL ; UÇGUN, N. IREM ; KILIÇ, NEDRET ; GÜRSEL, E. ; SEPICI-DINÇEL, AYLIN</creator><creatorcontrib>YILDIRIM, ZUHAL ; UÇGUN, N. IREM ; KILIÇ, NEDRET ; GÜRSEL, E. ; SEPICI-DINÇEL, AYLIN</creatorcontrib><description>: The aim of this study was to discuss the serum copper (Cu), zinc (Zn), nitric oxide (NO), glutathione (GSH), advanced oxidation protein products (AOPP) levels, and superoxide dismutase (SOD) activities with diabetic retinopathy severity. Twenty‐five patients with proliferative diabetic retinopathy (PDR group 1), 25 patients with nonproliferative diabetic retinopathy (NPDR group 2), and 25 nondiabetic controls (control group) were included in the study. Patients who had macrovascular complications of diabetes (coronary arterial disease, periferic vascular disease) were excluded. The major finding of our study was that we did not observe any differences between group 1 and 2, which we aimed to discuss the severity of diabetic retinopathy. As the levels of SOD and Zn were not different between the groups, statistically significant differences were observed for GSH, NO, and Cu levels when compared to control group. AOPP levels were statistically increased in group 1 compared to control group. It can be suggested that hyperglycemia in DM is associated with accelerated nonenzymatic glycation and oxidative stress.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1196/annals.1395.019</identifier><identifier>PMID: 17460179</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>advanced oxidation protein products ; Aged ; Antioxidants - metabolism ; copper ; Copper - blood ; Diabetes Complications - blood ; Diabetes Complications - genetics ; diabetic retinopathy ; Diabetic Retinopathy - enzymology ; Diabetic Retinopathy - genetics ; Female ; glutathione ; Glutathione - blood ; Humans ; Male ; Middle Aged ; nitric oxide ; Nitric Oxide - blood ; Oxidative Stress ; Oxygen - metabolism ; superoxide dismutase ; Superoxide Dismutase - blood ; Superoxide Dismutase - metabolism ; zinc ; Zinc - blood</subject><ispartof>Annals of the New York Academy of Sciences, 2007-04, Vol.1100 (1), p.199-206</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3779-7cadd68fe9225ddccdb90238dd305438727f98c650148613c3bd7ca6c03f25213</citedby><cites>FETCH-LOGICAL-c3779-7cadd68fe9225ddccdb90238dd305438727f98c650148613c3bd7ca6c03f25213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1196%2Fannals.1395.019$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1196%2Fannals.1395.019$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17460179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YILDIRIM, ZUHAL</creatorcontrib><creatorcontrib>UÇGUN, N. IREM</creatorcontrib><creatorcontrib>KILIÇ, NEDRET</creatorcontrib><creatorcontrib>GÜRSEL, E.</creatorcontrib><creatorcontrib>SEPICI-DINÇEL, AYLIN</creatorcontrib><title>Antioxidant Enzymes and Diabetic Retinopathy</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>: The aim of this study was to discuss the serum copper (Cu), zinc (Zn), nitric oxide (NO), glutathione (GSH), advanced oxidation protein products (AOPP) levels, and superoxide dismutase (SOD) activities with diabetic retinopathy severity. Twenty‐five patients with proliferative diabetic retinopathy (PDR group 1), 25 patients with nonproliferative diabetic retinopathy (NPDR group 2), and 25 nondiabetic controls (control group) were included in the study. Patients who had macrovascular complications of diabetes (coronary arterial disease, periferic vascular disease) were excluded. The major finding of our study was that we did not observe any differences between group 1 and 2, which we aimed to discuss the severity of diabetic retinopathy. As the levels of SOD and Zn were not different between the groups, statistically significant differences were observed for GSH, NO, and Cu levels when compared to control group. AOPP levels were statistically increased in group 1 compared to control group. It can be suggested that hyperglycemia in DM is associated with accelerated nonenzymatic glycation and oxidative stress.</description><subject>advanced oxidation protein products</subject><subject>Aged</subject><subject>Antioxidants - metabolism</subject><subject>copper</subject><subject>Copper - blood</subject><subject>Diabetes Complications - blood</subject><subject>Diabetes Complications - genetics</subject><subject>diabetic retinopathy</subject><subject>Diabetic Retinopathy - enzymology</subject><subject>Diabetic Retinopathy - genetics</subject><subject>Female</subject><subject>glutathione</subject><subject>Glutathione - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>nitric oxide</subject><subject>Nitric Oxide - blood</subject><subject>Oxidative Stress</subject><subject>Oxygen - metabolism</subject><subject>superoxide dismutase</subject><subject>Superoxide Dismutase - blood</subject><subject>Superoxide Dismutase - metabolism</subject><subject>zinc</subject><subject>Zinc - blood</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAYBi0EoqUws6FMTKT1R2LHYwWlIJUioAjBYjm2IwKJU-JUNPx6XFLByOJ3uXssHQDHCA4R4nQkrZWFGyLC4yFEfAf0EYt4SCnBu6APIWNhwjHpgQPn3iBEOInYPuh5iELEeB-cjW2TV-tcS9sEE_vVlsYF0urgIpepaXIV3PvXVkvZvLaHYC_z35mj7R2Ax8vJ4vwqnN1Or8_Hs1ARxnjIlNSaJpnhGMdaK6VTDjFJtCYwjkjCMMt4omgMUZRQRBRJtXeogiTDMUZkAE673WVdfayMa0SZO2WKQlpTrZxgMCLIux4cdaCqK-dqk4llnZeybgWCYhNIdIHEJpDwgbxxsp1epaXRf_y2iAdIB3zmhWn_2xPz5_HDz2zYWblrzPrXkvW7oIywWDzNp2KWvDB4RxfihnwDk7-A8w</recordid><startdate>200704</startdate><enddate>200704</enddate><creator>YILDIRIM, ZUHAL</creator><creator>UÇGUN, N. IREM</creator><creator>KILIÇ, NEDRET</creator><creator>GÜRSEL, E.</creator><creator>SEPICI-DINÇEL, AYLIN</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200704</creationdate><title>Antioxidant Enzymes and Diabetic Retinopathy</title><author>YILDIRIM, ZUHAL ; UÇGUN, N. IREM ; KILIÇ, NEDRET ; GÜRSEL, E. ; SEPICI-DINÇEL, AYLIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3779-7cadd68fe9225ddccdb90238dd305438727f98c650148613c3bd7ca6c03f25213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>advanced oxidation protein products</topic><topic>Aged</topic><topic>Antioxidants - metabolism</topic><topic>copper</topic><topic>Copper - blood</topic><topic>Diabetes Complications - blood</topic><topic>Diabetes Complications - genetics</topic><topic>diabetic retinopathy</topic><topic>Diabetic Retinopathy - enzymology</topic><topic>Diabetic Retinopathy - genetics</topic><topic>Female</topic><topic>glutathione</topic><topic>Glutathione - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>nitric oxide</topic><topic>Nitric Oxide - blood</topic><topic>Oxidative Stress</topic><topic>Oxygen - metabolism</topic><topic>superoxide dismutase</topic><topic>Superoxide Dismutase - blood</topic><topic>Superoxide Dismutase - metabolism</topic><topic>zinc</topic><topic>Zinc - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YILDIRIM, ZUHAL</creatorcontrib><creatorcontrib>UÇGUN, N. IREM</creatorcontrib><creatorcontrib>KILIÇ, NEDRET</creatorcontrib><creatorcontrib>GÜRSEL, E.</creatorcontrib><creatorcontrib>SEPICI-DINÇEL, AYLIN</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YILDIRIM, ZUHAL</au><au>UÇGUN, N. IREM</au><au>KILIÇ, NEDRET</au><au>GÜRSEL, E.</au><au>SEPICI-DINÇEL, AYLIN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant Enzymes and Diabetic Retinopathy</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2007-04</date><risdate>2007</risdate><volume>1100</volume><issue>1</issue><spage>199</spage><epage>206</epage><pages>199-206</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: The aim of this study was to discuss the serum copper (Cu), zinc (Zn), nitric oxide (NO), glutathione (GSH), advanced oxidation protein products (AOPP) levels, and superoxide dismutase (SOD) activities with diabetic retinopathy severity. Twenty‐five patients with proliferative diabetic retinopathy (PDR group 1), 25 patients with nonproliferative diabetic retinopathy (NPDR group 2), and 25 nondiabetic controls (control group) were included in the study. Patients who had macrovascular complications of diabetes (coronary arterial disease, periferic vascular disease) were excluded. The major finding of our study was that we did not observe any differences between group 1 and 2, which we aimed to discuss the severity of diabetic retinopathy. As the levels of SOD and Zn were not different between the groups, statistically significant differences were observed for GSH, NO, and Cu levels when compared to control group. AOPP levels were statistically increased in group 1 compared to control group. It can be suggested that hyperglycemia in DM is associated with accelerated nonenzymatic glycation and oxidative stress.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17460179</pmid><doi>10.1196/annals.1395.019</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 2007-04, Vol.1100 (1), p.199-206 |
| issn | 0077-8923 1749-6632 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70431148 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | advanced oxidation protein products Aged Antioxidants - metabolism copper Copper - blood Diabetes Complications - blood Diabetes Complications - genetics diabetic retinopathy Diabetic Retinopathy - enzymology Diabetic Retinopathy - genetics Female glutathione Glutathione - blood Humans Male Middle Aged nitric oxide Nitric Oxide - blood Oxidative Stress Oxygen - metabolism superoxide dismutase Superoxide Dismutase - blood Superoxide Dismutase - metabolism zinc Zinc - blood |
| title | Antioxidant Enzymes and Diabetic Retinopathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T05%3A49%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antioxidant%20Enzymes%20and%20Diabetic%20Retinopathy&rft.jtitle=Annals%20of%20the%20New%20York%20Academy%20of%20Sciences&rft.au=YILDIRIM,%20ZUHAL&rft.date=2007-04&rft.volume=1100&rft.issue=1&rft.spage=199&rft.epage=206&rft.pages=199-206&rft.issn=0077-8923&rft.eissn=1749-6632&rft_id=info:doi/10.1196/annals.1395.019&rft_dat=%3Cproquest_cross%3E70431148%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70431148&rft_id=info:pmid/17460179&rfr_iscdi=true |