Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice

Schizophrenic patients show decreased measures of sensorimotor gating, such as prepulse inhibition of startle (PPI). In preclinical models, these measures may be used to predict antipsychotic activity. While current antipsychotic drugs act largely at dopamine receptors, the muscarinic acetylcholine...

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Veröffentlicht in:	Psychopharmacologia 2007-05, Vol.192 (1), p.97-110
Hauptverfasser:	THOMSEN, Morgane, WÖRTWEIN, Gitta, FINK-JENSEN, Anders, WOLDBYE, David P. D, WESS, Jurgen, CAINE, S. Barak
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (muscarinic) Amphetamines Animals Antagonists Antipsychotic Agents - pharmacology Antipsychotics Behavior, Animal Biological and medical sciences Channel gating Clozapine Clozapine - pharmacology Cocaine Cocaine - pharmacology Dextroamphetamine - pharmacology Dopamine Agonists - pharmacology Dopamine receptors Drug therapy Drugs Female Genotype Genotypes Haloperidol Haloperidol - pharmacology Inhibitor drugs Male Medical sciences Mental disorders Mice Mice, Inbred C57BL Mice, Knockout Motor Activity - drug effects Muscarinic Agonists - pharmacology Neuropharmacology Pharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Psychotropic drugs Receptors, Muscarinic - drug effects Receptors, Muscarinic - genetics Reflex Reflex, Startle Rodents Schizophrenia Schizophrenia - drug therapy Schizophrenia - physiopathology Sensorimotor gating Trihexyphenidyl
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