Tenacibactins A−D, Hydroxamate Siderophores from a Marine-Derived Bacterium, Tenacibaculum sp. A4K-17

Four new hydroxamate siderophores, tenacibactins A−D (1−4), were isolated from a culture broth of the marine-derived bacterium Tenacibaculum sp. A4K-17. The structures of these tenacibactins were determined by NMR analyses and ESIMS/MS experiments. The iron-binding (chelating) activity of 1−4 was ev...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2007-04, Vol.70 (4), p.563-566
Hauptverfasser:	Jang, Jae-Hyuk, Kanoh, Kaneo, Adachi, Kyoko, Matsuda, Satoru, Shizuri, Yoshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied microbiology Bacteriology Biological and medical sciences Flavobacteriaceae - chemistry Fundamental and applied biological sciences. Psychology Hydroxamic Acids - chemistry Hydroxamic Acids - isolation & purification Hydroxamic Acids - pharmacology Hydroxybenzoates - pharmacology Iron Chelating Agents - chemistry Iron Chelating Agents - isolation & purification Iron Chelating Agents - pharmacology Marine Biology Microbiology Miscellaneous Molecular Structure Morphology, structure, chemical composition Nuclear Magnetic Resonance, Biomolecular Siderophores - chemistry Siderophores - isolation & purification Siderophores - pharmacology Tenacibaculum
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Zusammenfassung:	Four new hydroxamate siderophores, tenacibactins A−D (1−4), were isolated from a culture broth of the marine-derived bacterium Tenacibaculum sp. A4K-17. The structures of these tenacibactins were determined by NMR analyses and ESIMS/MS experiments. The iron-binding (chelating) activity of 1−4 was evaluated by the chrome azurol sulfonate (CAS) assay.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np060502b