Cross talk between Smad transcription factors and TNF-α in intervertebral disc degeneration
The transforming growth factor-β (TGF-β) and the tumor necrosis factor-α (TNF-α) families are known to play important roles in intervertebral disc degeneration (IVD). However, molecular interactions between the TGF-β and TNF-α signaling pathways have yet to be elucidated. The purpose of this study w...
Gespeichert in:
| Veröffentlicht in: | Biochemical and biophysical research communications 2008-05, Vol.369 (2), p.679-685 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 685 |
|---|---|
| container_issue | 2 |
| container_start_page | 679 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 369 |
| creator | Hiyama, A. Mochida, J. Omi, H. Serigano, K. Sakai, D. |
| description | The transforming growth factor-β (TGF-β) and the tumor necrosis factor-α (TNF-α) families are known to play important roles in intervertebral disc degeneration (IVD). However, molecular interactions between the TGF-β and TNF-α signaling pathways have yet to be elucidated. The purpose of this study was to analyze the expression patterns of Smad transcription factor signaling associated with IVDs with aging and to examine the modulation of Smad signaling by TNF-α in IVD cells using SD rats. According to these experimental results, BMP signals in the TGF-β family were more likely to be a key factor in IVD degeneration by aging, and it was predicted that besides the involvement of catabolic factors like MMPs and ADAMS-TS, there may be a decrease in expression of anabolic factors through cross talk of signaling between TNF-α and TGF-β pathway in pathogenesis of disc degeneration. |
| doi_str_mv | 10.1016/j.bbrc.2008.02.087 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70430314</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006291X08003483</els_id><sourcerecordid>20776292</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-32b778425178c59a0eb735ebdc3acfe35b07c0ef1882cc51919e4b95fb6502703</originalsourceid><addsrcrecordid>eNqFkM1q3DAUhUVpaCZpX6CLoFV3dq8k27IgmzBkksLQLJJAFwUhyddFU_9MJE1CHisv0meKzQxkl8KFs_nO4fIR8pVBzoBV3ze5tcHlHKDOgedQyw9kwUBBxhkUH8kCAKqMK_brmJzEuAFgrKjUJ3LMagFSyWJBfi_DGCNNpvtLLaYnxIHe9qahKZghuuC3yY8DbY1LY4jUDA29-7nK_r1QP0yXMDxiSGiD6Wjjo6MN_sEBg5lrn8lRa7qIXw55Su5Xl3fL62x9c_VjebHOnKjLlAlupawLXjJZu1IZQCtFibZxwrgWRWlBOsCW1TV3rmSKKSysKltblcAliFPybb-7DePDDmPS_fQKdp0ZcNxFLaEQIFjxX5CDlBVXfAL5HnSznoCt3gbfm_CsGehZvt7oWb6e5WvgepI_lc4O6zvbY_NWOdiegPM9gJOMR49BR-dxcNj4gC7pZvTv7b8CH9yWkw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20776292</pqid></control><display><type>article</type><title>Cross talk between Smad transcription factors and TNF-α in intervertebral disc degeneration</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Hiyama, A. ; Mochida, J. ; Omi, H. ; Serigano, K. ; Sakai, D.</creator><creatorcontrib>Hiyama, A. ; Mochida, J. ; Omi, H. ; Serigano, K. ; Sakai, D.</creatorcontrib><description>The transforming growth factor-β (TGF-β) and the tumor necrosis factor-α (TNF-α) families are known to play important roles in intervertebral disc degeneration (IVD). However, molecular interactions between the TGF-β and TNF-α signaling pathways have yet to be elucidated. The purpose of this study was to analyze the expression patterns of Smad transcription factor signaling associated with IVDs with aging and to examine the modulation of Smad signaling by TNF-α in IVD cells using SD rats. According to these experimental results, BMP signals in the TGF-β family were more likely to be a key factor in IVD degeneration by aging, and it was predicted that besides the involvement of catabolic factors like MMPs and ADAMS-TS, there may be a decrease in expression of anabolic factors through cross talk of signaling between TNF-α and TGF-β pathway in pathogenesis of disc degeneration.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2008.02.087</identifier><identifier>PMID: 18307974</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Disc degeneration ; Female ; Intervertebral disc ; Intervertebral Disc - metabolism ; Intervertebral Disc - pathology ; Intervertebral Disc Displacement - metabolism ; Intervertebral Disc Displacement - pathology ; Nucleus pulposus ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Smad ; Smad Proteins - metabolism ; TNF-alpha ; Transcription Factors - metabolism ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Biochemical and biophysical research communications, 2008-05, Vol.369 (2), p.679-685</ispartof><rights>2008 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-32b778425178c59a0eb735ebdc3acfe35b07c0ef1882cc51919e4b95fb6502703</citedby><cites>FETCH-LOGICAL-c385t-32b778425178c59a0eb735ebdc3acfe35b07c0ef1882cc51919e4b95fb6502703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X08003483$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18307974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hiyama, A.</creatorcontrib><creatorcontrib>Mochida, J.</creatorcontrib><creatorcontrib>Omi, H.</creatorcontrib><creatorcontrib>Serigano, K.</creatorcontrib><creatorcontrib>Sakai, D.</creatorcontrib><title>Cross talk between Smad transcription factors and TNF-α in intervertebral disc degeneration</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The transforming growth factor-β (TGF-β) and the tumor necrosis factor-α (TNF-α) families are known to play important roles in intervertebral disc degeneration (IVD). However, molecular interactions between the TGF-β and TNF-α signaling pathways have yet to be elucidated. The purpose of this study was to analyze the expression patterns of Smad transcription factor signaling associated with IVDs with aging and to examine the modulation of Smad signaling by TNF-α in IVD cells using SD rats. According to these experimental results, BMP signals in the TGF-β family were more likely to be a key factor in IVD degeneration by aging, and it was predicted that besides the involvement of catabolic factors like MMPs and ADAMS-TS, there may be a decrease in expression of anabolic factors through cross talk of signaling between TNF-α and TGF-β pathway in pathogenesis of disc degeneration.</description><subject>Animals</subject><subject>Disc degeneration</subject><subject>Female</subject><subject>Intervertebral disc</subject><subject>Intervertebral Disc - metabolism</subject><subject>Intervertebral Disc - pathology</subject><subject>Intervertebral Disc Displacement - metabolism</subject><subject>Intervertebral Disc Displacement - pathology</subject><subject>Nucleus pulposus</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Signal Transduction</subject><subject>Smad</subject><subject>Smad Proteins - metabolism</subject><subject>TNF-alpha</subject><subject>Transcription Factors - metabolism</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1q3DAUhUVpaCZpX6CLoFV3dq8k27IgmzBkksLQLJJAFwUhyddFU_9MJE1CHisv0meKzQxkl8KFs_nO4fIR8pVBzoBV3ze5tcHlHKDOgedQyw9kwUBBxhkUH8kCAKqMK_brmJzEuAFgrKjUJ3LMagFSyWJBfi_DGCNNpvtLLaYnxIHe9qahKZghuuC3yY8DbY1LY4jUDA29-7nK_r1QP0yXMDxiSGiD6Wjjo6MN_sEBg5lrn8lRa7qIXw55Su5Xl3fL62x9c_VjebHOnKjLlAlupawLXjJZu1IZQCtFibZxwrgWRWlBOsCW1TV3rmSKKSysKltblcAliFPybb-7DePDDmPS_fQKdp0ZcNxFLaEQIFjxX5CDlBVXfAL5HnSznoCt3gbfm_CsGehZvt7oWb6e5WvgepI_lc4O6zvbY_NWOdiegPM9gJOMR49BR-dxcNj4gC7pZvTv7b8CH9yWkw</recordid><startdate>20080502</startdate><enddate>20080502</enddate><creator>Hiyama, A.</creator><creator>Mochida, J.</creator><creator>Omi, H.</creator><creator>Serigano, K.</creator><creator>Sakai, D.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20080502</creationdate><title>Cross talk between Smad transcription factors and TNF-α in intervertebral disc degeneration</title><author>Hiyama, A. ; Mochida, J. ; Omi, H. ; Serigano, K. ; Sakai, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-32b778425178c59a0eb735ebdc3acfe35b07c0ef1882cc51919e4b95fb6502703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Disc degeneration</topic><topic>Female</topic><topic>Intervertebral disc</topic><topic>Intervertebral Disc - metabolism</topic><topic>Intervertebral Disc - pathology</topic><topic>Intervertebral Disc Displacement - metabolism</topic><topic>Intervertebral Disc Displacement - pathology</topic><topic>Nucleus pulposus</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Signal Transduction</topic><topic>Smad</topic><topic>Smad Proteins - metabolism</topic><topic>TNF-alpha</topic><topic>Transcription Factors - metabolism</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hiyama, A.</creatorcontrib><creatorcontrib>Mochida, J.</creatorcontrib><creatorcontrib>Omi, H.</creatorcontrib><creatorcontrib>Serigano, K.</creatorcontrib><creatorcontrib>Sakai, D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hiyama, A.</au><au>Mochida, J.</au><au>Omi, H.</au><au>Serigano, K.</au><au>Sakai, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cross talk between Smad transcription factors and TNF-α in intervertebral disc degeneration</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2008-05-02</date><risdate>2008</risdate><volume>369</volume><issue>2</issue><spage>679</spage><epage>685</epage><pages>679-685</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The transforming growth factor-β (TGF-β) and the tumor necrosis factor-α (TNF-α) families are known to play important roles in intervertebral disc degeneration (IVD). However, molecular interactions between the TGF-β and TNF-α signaling pathways have yet to be elucidated. The purpose of this study was to analyze the expression patterns of Smad transcription factor signaling associated with IVDs with aging and to examine the modulation of Smad signaling by TNF-α in IVD cells using SD rats. According to these experimental results, BMP signals in the TGF-β family were more likely to be a key factor in IVD degeneration by aging, and it was predicted that besides the involvement of catabolic factors like MMPs and ADAMS-TS, there may be a decrease in expression of anabolic factors through cross talk of signaling between TNF-α and TGF-β pathway in pathogenesis of disc degeneration.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18307974</pmid><doi>10.1016/j.bbrc.2008.02.087</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 2008-05, Vol.369 (2), p.679-685 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70430314 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Disc degeneration Female Intervertebral disc Intervertebral Disc - metabolism Intervertebral Disc - pathology Intervertebral Disc Displacement - metabolism Intervertebral Disc Displacement - pathology Nucleus pulposus Rats Rats, Sprague-Dawley Signal Transduction Smad Smad Proteins - metabolism TNF-alpha Transcription Factors - metabolism Tumor Necrosis Factor-alpha - metabolism |
| title | Cross talk between Smad transcription factors and TNF-α in intervertebral disc degeneration |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T21%3A14%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cross%20talk%20between%20Smad%20transcription%20factors%20and%20TNF-%CE%B1%20in%20intervertebral%20disc%20degeneration&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Hiyama,%20A.&rft.date=2008-05-02&rft.volume=369&rft.issue=2&rft.spage=679&rft.epage=685&rft.pages=679-685&rft.issn=0006-291X&rft.eissn=1090-2104&rft_id=info:doi/10.1016/j.bbrc.2008.02.087&rft_dat=%3Cproquest_cross%3E20776292%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20776292&rft_id=info:pmid/18307974&rft_els_id=S0006291X08003483&rfr_iscdi=true |