Evidence for multiple mitochondrial lineages of Fasciola hepatica (liver fluke) within infrapopulations from cattle and sheep

The economic, veterinary, and medical impact of the parasite Fasciola hepatica, liver fluke, is difficult to alleviate due to increasing incidences of resistance to the principal anthelmintic drugs. These have occurred in widely separated regions. The rate of response to selection imposed by such dr...

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Veröffentlicht in:Parasitology research (1987) 2007-06, Vol.101 (1), p.117-125
Hauptverfasser: Walker, S. M, Prodöhl, P. A, Fletcher, H. L, Hanna, R. E. B, Kantzoura, V, Hoey, E. M, Trudgett, A
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container_end_page 125
container_issue 1
container_start_page 117
container_title Parasitology research (1987)
container_volume 101
creator Walker, S. M
Prodöhl, P. A
Fletcher, H. L
Hanna, R. E. B
Kantzoura, V
Hoey, E. M
Trudgett, A
description The economic, veterinary, and medical impact of the parasite Fasciola hepatica, liver fluke, is difficult to alleviate due to increasing incidences of resistance to the principal anthelmintic drugs. These have occurred in widely separated regions. The rate of response to selection imposed by such drugs will be dependent on the genetic variation present in the F. hepatica gene pool, but this is at present unknown. We have assessed the genetic diversity of mitochondrial haplotypes found in the infrapopulation of flukes recovered from a calf of known provenance and from six other cattle and sheep hosts located in Ireland and four from elsewhere. Our results revealed that at least ten different mitochondrial composite PCR-restriction fragment length polymorphism haplotypes had been acquired by a single animal in 1 year, and there was comparable diversity in six other definitive hosts carrying field-acquired infections. The extent of divergence between these fluke lineages suggests that they predate the last ice age and, thus, cannot have developed in Northern Europe. A consequence of this high level of diversity is that there will be frequent selection for anthelmintic resistance and rapid responses to climatic changes.
doi_str_mv 10.1007/s00436-006-0440-4
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Our results revealed that at least ten different mitochondrial composite PCR-restriction fragment length polymorphism haplotypes had been acquired by a single animal in 1 year, and there was comparable diversity in six other definitive hosts carrying field-acquired infections. The extent of divergence between these fluke lineages suggests that they predate the last ice age and, thus, cannot have developed in Northern Europe. 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Models ; Genetic Variation ; Greece - epidemiology ; Haplotypes ; Invertebrates ; Ireland - epidemiology ; liver flukes ; Mammalia ; Netherlands - epidemiology ; PCR-RFLP ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; population structure ; Sheep ; Sheep Diseases - epidemiology ; Sheep Diseases - parasitology ; Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution</subject><ispartof>Parasitology research (1987), 2007-06, Vol.101 (1), p.117-125</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-1b62ff8718317cb9c1673892a557ede8d276ed76889df8c7c8f306cffe3cad553</citedby><cites>FETCH-LOGICAL-c353t-1b62ff8718317cb9c1673892a557ede8d276ed76889df8c7c8f306cffe3cad553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=18756873$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17216485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walker, S. 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subjects Animals
Biological and medical sciences
Cattle
Cattle Diseases - epidemiology
Cattle Diseases - parasitology
DNA, Mitochondrial - genetics
drug resistance
Fasciola hepatica - cytology
Fasciola hepatica - genetics
fascioliasis
Fascioliasis - epidemiology
Fascioliasis - parasitology
Fascioliasis - veterinary
Fundamental and applied biological sciences. Psychology
General aspects
General aspects and techniques. Study of several systematic groups. Models
Genetic Variation
Greece - epidemiology
Haplotypes
Invertebrates
Ireland - epidemiology
liver flukes
Mammalia
Netherlands - epidemiology
PCR-RFLP
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
population structure
Sheep
Sheep Diseases - epidemiology
Sheep Diseases - parasitology
Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution
title Evidence for multiple mitochondrial lineages of Fasciola hepatica (liver fluke) within infrapopulations from cattle and sheep
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