Evidence for multiple mitochondrial lineages of Fasciola hepatica (liver fluke) within infrapopulations from cattle and sheep
The economic, veterinary, and medical impact of the parasite Fasciola hepatica, liver fluke, is difficult to alleviate due to increasing incidences of resistance to the principal anthelmintic drugs. These have occurred in widely separated regions. The rate of response to selection imposed by such dr...
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creator | Walker, S. M Prodöhl, P. A Fletcher, H. L Hanna, R. E. B Kantzoura, V Hoey, E. M Trudgett, A |
description | The economic, veterinary, and medical impact of the parasite Fasciola hepatica, liver fluke, is difficult to alleviate due to increasing incidences of resistance to the principal anthelmintic drugs. These have occurred in widely separated regions. The rate of response to selection imposed by such drugs will be dependent on the genetic variation present in the F. hepatica gene pool, but this is at present unknown. We have assessed the genetic diversity of mitochondrial haplotypes found in the infrapopulation of flukes recovered from a calf of known provenance and from six other cattle and sheep hosts located in Ireland and four from elsewhere. Our results revealed that at least ten different mitochondrial composite PCR-restriction fragment length polymorphism haplotypes had been acquired by a single animal in 1 year, and there was comparable diversity in six other definitive hosts carrying field-acquired infections. The extent of divergence between these fluke lineages suggests that they predate the last ice age and, thus, cannot have developed in Northern Europe. A consequence of this high level of diversity is that there will be frequent selection for anthelmintic resistance and rapid responses to climatic changes. |
doi_str_mv | 10.1007/s00436-006-0440-4 |
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M ; Prodöhl, P. A ; Fletcher, H. L ; Hanna, R. E. B ; Kantzoura, V ; Hoey, E. M ; Trudgett, A</creator><creatorcontrib>Walker, S. M ; Prodöhl, P. A ; Fletcher, H. L ; Hanna, R. E. B ; Kantzoura, V ; Hoey, E. M ; Trudgett, A</creatorcontrib><description>The economic, veterinary, and medical impact of the parasite Fasciola hepatica, liver fluke, is difficult to alleviate due to increasing incidences of resistance to the principal anthelmintic drugs. These have occurred in widely separated regions. The rate of response to selection imposed by such drugs will be dependent on the genetic variation present in the F. hepatica gene pool, but this is at present unknown. We have assessed the genetic diversity of mitochondrial haplotypes found in the infrapopulation of flukes recovered from a calf of known provenance and from six other cattle and sheep hosts located in Ireland and four from elsewhere. Our results revealed that at least ten different mitochondrial composite PCR-restriction fragment length polymorphism haplotypes had been acquired by a single animal in 1 year, and there was comparable diversity in six other definitive hosts carrying field-acquired infections. The extent of divergence between these fluke lineages suggests that they predate the last ice age and, thus, cannot have developed in Northern Europe. A consequence of this high level of diversity is that there will be frequent selection for anthelmintic resistance and rapid responses to climatic changes.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-006-0440-4</identifier><identifier>PMID: 17216485</identifier><identifier>CODEN: PARREZ</identifier><language>eng</language><publisher>Berlin: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Animals ; Biological and medical sciences ; Cattle ; Cattle Diseases - epidemiology ; Cattle Diseases - parasitology ; DNA, Mitochondrial - genetics ; drug resistance ; Fasciola hepatica - cytology ; Fasciola hepatica - genetics ; fascioliasis ; Fascioliasis - epidemiology ; Fascioliasis - parasitology ; Fascioliasis - veterinary ; Fundamental and applied biological sciences. Psychology ; General aspects ; General aspects and techniques. Study of several systematic groups. Models ; Genetic Variation ; Greece - epidemiology ; Haplotypes ; Invertebrates ; Ireland - epidemiology ; liver flukes ; Mammalia ; Netherlands - epidemiology ; PCR-RFLP ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; population structure ; Sheep ; Sheep Diseases - epidemiology ; Sheep Diseases - parasitology ; Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution</subject><ispartof>Parasitology research (1987), 2007-06, Vol.101 (1), p.117-125</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-1b62ff8718317cb9c1673892a557ede8d276ed76889df8c7c8f306cffe3cad553</citedby><cites>FETCH-LOGICAL-c353t-1b62ff8718317cb9c1673892a557ede8d276ed76889df8c7c8f306cffe3cad553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18756873$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17216485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walker, S. M</creatorcontrib><creatorcontrib>Prodöhl, P. A</creatorcontrib><creatorcontrib>Fletcher, H. L</creatorcontrib><creatorcontrib>Hanna, R. E. B</creatorcontrib><creatorcontrib>Kantzoura, V</creatorcontrib><creatorcontrib>Hoey, E. M</creatorcontrib><creatorcontrib>Trudgett, A</creatorcontrib><title>Evidence for multiple mitochondrial lineages of Fasciola hepatica (liver fluke) within infrapopulations from cattle and sheep</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><description>The economic, veterinary, and medical impact of the parasite Fasciola hepatica, liver fluke, is difficult to alleviate due to increasing incidences of resistance to the principal anthelmintic drugs. These have occurred in widely separated regions. The rate of response to selection imposed by such drugs will be dependent on the genetic variation present in the F. hepatica gene pool, but this is at present unknown. We have assessed the genetic diversity of mitochondrial haplotypes found in the infrapopulation of flukes recovered from a calf of known provenance and from six other cattle and sheep hosts located in Ireland and four from elsewhere. Our results revealed that at least ten different mitochondrial composite PCR-restriction fragment length polymorphism haplotypes had been acquired by a single animal in 1 year, and there was comparable diversity in six other definitive hosts carrying field-acquired infections. The extent of divergence between these fluke lineages suggests that they predate the last ice age and, thus, cannot have developed in Northern Europe. A consequence of this high level of diversity is that there will be frequent selection for anthelmintic resistance and rapid responses to climatic changes.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cattle Diseases - epidemiology</subject><subject>Cattle Diseases - parasitology</subject><subject>DNA, Mitochondrial - genetics</subject><subject>drug resistance</subject><subject>Fasciola hepatica - cytology</subject><subject>Fasciola hepatica - genetics</subject><subject>fascioliasis</subject><subject>Fascioliasis - epidemiology</subject><subject>Fascioliasis - parasitology</subject><subject>Fascioliasis - veterinary</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>General aspects and techniques. Study of several systematic groups. Models</subject><subject>Genetic Variation</subject><subject>Greece - epidemiology</subject><subject>Haplotypes</subject><subject>Invertebrates</subject><subject>Ireland - epidemiology</subject><subject>liver flukes</subject><subject>Mammalia</subject><subject>Netherlands - epidemiology</subject><subject>PCR-RFLP</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>population structure</subject><subject>Sheep</subject><subject>Sheep Diseases - epidemiology</subject><subject>Sheep Diseases - parasitology</subject><subject>Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution</subject><issn>0932-0113</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkT1vFDEQhi0EIkfgB9CAGxAUC_b6c0sUJYAUiQJSWz57nDN47cXeDaLgv-PoTkoxmimeeUd6BqGXlHyghKiPjRDO5EBIL87JwB-hHeVsHOgkxGO0I1OfCaXsDD1r7SchVEnOn6IzqkYquRY79O_yLnrIDnAoFc9bWuOSAM9xLe5Qsq_RJpxiBnsLDZeAr2xzsSSLD7DYNTqL36V4BxWHtP2C9_hPXA8x45hDtUtZttShkhsOtczY2XXt6TZ73A4Ay3P0JNjU4MWpn6Obq8sfF1-G62-fv158uh4cE2wd6F6OIWhFNaPK7SdHpWJ6Gq0QCjxoPyoJXkmtJx-0U04HRqQLAZizXgh2jt4ec5dafm_QVjPH5iAlm6FszajukTAydpAeQVdLaxWCWWqcbf1rKDH3zs3RuenOzb1zw_vOq1P4tp_BP2ycJHfgzQno7mzqYrKL7YHTSkitWOdeH7lgi7G3tTM330dCWb-rqOzf_A9J9ZT7</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Walker, S. M</creator><creator>Prodöhl, P. A</creator><creator>Fletcher, H. L</creator><creator>Hanna, R. E. B</creator><creator>Kantzoura, V</creator><creator>Hoey, E. M</creator><creator>Trudgett, A</creator><general>Berlin/Heidelberg : Springer-Verlag</general><general>Springer</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>Evidence for multiple mitochondrial lineages of Fasciola hepatica (liver fluke) within infrapopulations from cattle and sheep</title><author>Walker, S. M ; Prodöhl, P. A ; Fletcher, H. L ; Hanna, R. E. B ; Kantzoura, V ; Hoey, E. M ; Trudgett, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-1b62ff8718317cb9c1673892a557ede8d276ed76889df8c7c8f306cffe3cad553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Cattle Diseases - epidemiology</topic><topic>Cattle Diseases - parasitology</topic><topic>DNA, Mitochondrial - genetics</topic><topic>drug resistance</topic><topic>Fasciola hepatica - cytology</topic><topic>Fasciola hepatica - genetics</topic><topic>fascioliasis</topic><topic>Fascioliasis - epidemiology</topic><topic>Fascioliasis - parasitology</topic><topic>Fascioliasis - veterinary</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>General aspects and techniques. Study of several systematic groups. Models</topic><topic>Genetic Variation</topic><topic>Greece - epidemiology</topic><topic>Haplotypes</topic><topic>Invertebrates</topic><topic>Ireland - epidemiology</topic><topic>liver flukes</topic><topic>Mammalia</topic><topic>Netherlands - epidemiology</topic><topic>PCR-RFLP</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>population structure</topic><topic>Sheep</topic><topic>Sheep Diseases - epidemiology</topic><topic>Sheep Diseases - parasitology</topic><topic>Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walker, S. M</creatorcontrib><creatorcontrib>Prodöhl, P. A</creatorcontrib><creatorcontrib>Fletcher, H. L</creatorcontrib><creatorcontrib>Hanna, R. E. B</creatorcontrib><creatorcontrib>Kantzoura, V</creatorcontrib><creatorcontrib>Hoey, E. M</creatorcontrib><creatorcontrib>Trudgett, A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walker, S. M</au><au>Prodöhl, P. A</au><au>Fletcher, H. L</au><au>Hanna, R. E. B</au><au>Kantzoura, V</au><au>Hoey, E. M</au><au>Trudgett, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for multiple mitochondrial lineages of Fasciola hepatica (liver fluke) within infrapopulations from cattle and sheep</atitle><jtitle>Parasitology research (1987)</jtitle><addtitle>Parasitol Res</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>101</volume><issue>1</issue><spage>117</spage><epage>125</epage><pages>117-125</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><coden>PARREZ</coden><abstract>The economic, veterinary, and medical impact of the parasite Fasciola hepatica, liver fluke, is difficult to alleviate due to increasing incidences of resistance to the principal anthelmintic drugs. These have occurred in widely separated regions. The rate of response to selection imposed by such drugs will be dependent on the genetic variation present in the F. hepatica gene pool, but this is at present unknown. We have assessed the genetic diversity of mitochondrial haplotypes found in the infrapopulation of flukes recovered from a calf of known provenance and from six other cattle and sheep hosts located in Ireland and four from elsewhere. Our results revealed that at least ten different mitochondrial composite PCR-restriction fragment length polymorphism haplotypes had been acquired by a single animal in 1 year, and there was comparable diversity in six other definitive hosts carrying field-acquired infections. The extent of divergence between these fluke lineages suggests that they predate the last ice age and, thus, cannot have developed in Northern Europe. A consequence of this high level of diversity is that there will be frequent selection for anthelmintic resistance and rapid responses to climatic changes.</abstract><cop>Berlin</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>17216485</pmid><doi>10.1007/s00436-006-0440-4</doi><tpages>9</tpages></addata></record> |
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subjects | Animals Biological and medical sciences Cattle Cattle Diseases - epidemiology Cattle Diseases - parasitology DNA, Mitochondrial - genetics drug resistance Fasciola hepatica - cytology Fasciola hepatica - genetics fascioliasis Fascioliasis - epidemiology Fascioliasis - parasitology Fascioliasis - veterinary Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models Genetic Variation Greece - epidemiology Haplotypes Invertebrates Ireland - epidemiology liver flukes Mammalia Netherlands - epidemiology PCR-RFLP Polymerase Chain Reaction Polymorphism, Restriction Fragment Length population structure Sheep Sheep Diseases - epidemiology Sheep Diseases - parasitology Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution |
title | Evidence for multiple mitochondrial lineages of Fasciola hepatica (liver fluke) within infrapopulations from cattle and sheep |
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