Chemokine receptors expression and migration potential of tumor-infiltrating and peripheral-expanded Vgamma9Vdelta2 T cells from renal cell carcinoma patients

We previously showed that Vdelta2 T cells infiltrate renal tumors and can be expanded as potent cytotoxic effectors from peripheral blood mononuclear cells of most renal cell carcinoma (RCC) patients, using a structural analog of nonconventional T-cell receptor gamma9delta2 ligand, bromohydrin pyrop...

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Veröffentlicht in:	Journal of immunotherapy (1997) 2008-04, Vol.31 (3), p.313-323
Hauptverfasser:	Viey, Emilie, Lucas, Claire, Romagne, François, Escudier, Bernard, Chouaib, Salem, Caignard, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - pathology Cell Movement - genetics Cell Movement - immunology Cell Proliferation - drug effects Cells, Cultured Chemokine CXCL12 - genetics Chemokine CXCL12 - immunology Chemotaxis, Leukocyte - genetics Diphosphates - pharmacology Gene Expression Profiling Humans Immunologic Memory Interleukin-15 - pharmacology Kidney Neoplasms - immunology Kidney Neoplasms - pathology Lymphocyte Activation - drug effects Lymphocyte Subsets - immunology Lymphocyte Subsets - pathology Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - pathology Protein Array Analysis Receptors, Antigen, T-Cell, gamma-delta - biosynthesis Receptors, Antigen, T-Cell, gamma-delta - genetics Receptors, Antigen, T-Cell, gamma-delta - immunology Receptors, Chemokine - biosynthesis Receptors, Chemokine - genetics Receptors, Chemokine - immunology Receptors, CXCR4 - genetics Receptors, CXCR4 - immunology T-Lymphocytes - immunology T-Lymphocytes - pathology
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