Analysis of the binding of gluten T-cell epitopes to various human leukocyte antigen class II molecules

Summary Celiac disease is a prevalent disorder of the small intestine that is caused by an inflammatory reaction to dietary gluten in genetically susceptible individuals. More than 90% of patients express the HLA-DQ2 molecule, whereas DQ8 is carried by most of the remaining patients. DQ2- and DQ8-me...

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Veröffentlicht in:	Human immunology 2008-02, Vol.69 (2), p.94-100
Hauptverfasser:	Bergseng, Elin, Sidney, John, Sette, Alessandro, Sollid, Ludvig M
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Antigen Presentation - immunology Binding Sites Binding, Competitive CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Celiac disease Celiac Disease - immunology DQ2 Epitopes, T-Lymphocyte - immunology Epitopes, T-Lymphocyte - metabolism Genetic Predisposition to Disease Gluten T-cell epitopes Glutens - chemistry Glutens - immunology Glutens - metabolism HLA class II molecules HLA-D Antigens - immunology HLA-D Antigens - metabolism HLA-DQ Antigens - immunology HLA-DQ Antigens - metabolism Humans Hydrogen Bonding Peptide binding Peptide Fragments - chemistry Peptide Fragments - immunology Peptide Fragments - metabolism Radioligand Assay
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