Long-Term Continuous Treatment with Sildenafil Ameliorates Aging-Related Erectile Dysfunction and the Underlying Corporal Fibrosis in the Rat

Aging-related erectile dysfunction is characterized by a loss of smooth muscle cells (SMCs) and fibrosis in the corpora cavernosa, and functionally by corporal veno-occlusive dysfunction (CVOD). Phosphodiesterase 5 (PDE5A) inhibitors, in part via upregulating inducible nitric oxide synthase (NOS2A),...

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Veröffentlicht in:	Biology of reproduction 2007-05, Vol.76 (5), p.915-923
Hauptverfasser:	FERRINI, M. G, KOVANECZ, I, SANCHEZ, S, VERNET, D, DAVILA, H. H, RAJFER, J, GONZALEZ -CADAVID, N. F
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors Aging - physiology Animals Biological and medical sciences Blotting, Western Collagen - metabolism Cyclic Nucleotide Phosphodiesterases, Type 5 Erectile Dysfunction - drug therapy Erectile Dysfunction - pathology Fibrosis Genitalia, Male - enzymology Genitalia, Male - metabolism Genitalia, Male - pathology Gynecology. Andrology. Obstetrics Image Processing, Computer-Assisted Immunohistochemistry In Situ Nick-End Labeling Male Male genital diseases Medical sciences Muscle, Smooth - cytology Muscle, Smooth - drug effects Muscle, Smooth - metabolism Nitric Oxide Synthase Type II - biosynthesis Nitric Oxide Synthase Type II - genetics Non tumoral diseases Oxidative Stress - physiology Penis - cytology Penis - metabolism Phosphodiesterase Inhibitors - therapeutic use Piperazines - therapeutic use Proliferating Cell Nuclear Antigen - metabolism Purines - therapeutic use Rats Rats, Inbred F344 Sildenafil Citrate Sulfones - therapeutic use Up-Regulation - drug effects
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