Finasteride induces apoptosis via Bcl-2, Bcl-xL, Bax and caspase-3 proteins in LNCaP human prostate cancer cell line

We investigated the effects of finasteride, a 5alpha-reductase inhibitor, on cell death machinery through the induction of apoptosis in an in vitro model for prostate cancer. Finasteride treatment of the LNCaP hormone-dependent human prostate cancer cell line caused the loss of cell viability and ac...

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Veröffentlicht in:	International journal of oncology 2008-04, Vol.32 (4), p.919-924
Hauptverfasser:	GOLBANO, Jesus M, LOPEZ-APARICIO, Pilar, RECIO, Maria N, PEREZ-ALBARSANZ, Miguel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects bcl-2-Associated X Protein - physiology bcl-X Protein - physiology Biological and medical sciences Caspase 3 - physiology Cell Line, Tumor Cholestenone 5 alpha-Reductase - antagonists & inhibitors Enzyme Inhibitors - pharmacology Finasteride - pharmacology Humans Male Medical sciences Nephrology. Urinary tract diseases Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-bcl-2 - physiology Tumors Tumors of the urinary system Urinary tract. Prostate gland
Online-Zugang:	Volltext
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