Retinal Abnormalities in Early Alzheimer's Disease
There is evidence suggesting that visual disturbances in patients with Alzheimer's Disease (AD) are due to pathologic changes in the retina and optic nerve, as well as to higher cortical impairment. The purpose of this study was to evaluate retinal hemodynamic parameters and to characterize pat...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 2007-05, Vol.48 (5), p.2285-2289 |
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| creator | Berisha, Fatmire Feke, Gilbert T Trempe, Clement L McMeel, J. Wallace Schepens, Charles L |
| description | There is evidence suggesting that visual disturbances in patients with Alzheimer's Disease (AD) are due to pathologic changes in the retina and optic nerve, as well as to higher cortical impairment. The purpose of this study was to evaluate retinal hemodynamic parameters and to characterize patterns of retinal nerve fiber layer (RNFL) loss in patients with early AD.
Nine patients with mild to moderate probable AD (mean Mini Mental State Examination score 24 of a possible 30 (age 74.3 +/- 3.3 years; mean +/- SD) and eight age-matched control subjects (age, 74.3 +/- 5.8 years) were included in this prospective cross-sectional study. Blood column diameter, blood velocity, and blood flow rate were measured in the major superior temporal retinal vein in each subject by using a laser Doppler instrument. Peripapillary RNFL was measured by optical coherence tomography.
Patients with AD showed a significant narrowing of the venous blood column diameter (131.7 +/- 10.8 microm) compared with control subjects (148.3 +/- 12.7 microm, P = 0.01), and a significantly reduced venous blood flow rate (9.7 +/- 3.1 microL/min) compared with the control subjects (15.9 +/- 3.7 microL/min, P = 0.002). A significant thinning of the RNFL was found in the superior quadrant in patients with AD (92.2 +/- 21.6 microm) compared with control subjects (113.6 +/- 10.7 microm, P = 0.02). There were no significant differences in the inferior, temporal, or nasal RNFL thicknesses between the groups.
Retinal abnormalities in early AD include a specific pattern of RNFL loss, narrow veins, and decreased retinal blood flow in these veins. The results show that AD produces quantifiable abnormalities in the retina. |
| doi_str_mv | 10.1167/iovs.06-1029 |
| format | Article |
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Nine patients with mild to moderate probable AD (mean Mini Mental State Examination score 24 of a possible 30 (age 74.3 +/- 3.3 years; mean +/- SD) and eight age-matched control subjects (age, 74.3 +/- 5.8 years) were included in this prospective cross-sectional study. Blood column diameter, blood velocity, and blood flow rate were measured in the major superior temporal retinal vein in each subject by using a laser Doppler instrument. Peripapillary RNFL was measured by optical coherence tomography.
Patients with AD showed a significant narrowing of the venous blood column diameter (131.7 +/- 10.8 microm) compared with control subjects (148.3 +/- 12.7 microm, P = 0.01), and a significantly reduced venous blood flow rate (9.7 +/- 3.1 microL/min) compared with the control subjects (15.9 +/- 3.7 microL/min, P = 0.002). A significant thinning of the RNFL was found in the superior quadrant in patients with AD (92.2 +/- 21.6 microm) compared with control subjects (113.6 +/- 10.7 microm, P = 0.02). There were no significant differences in the inferior, temporal, or nasal RNFL thicknesses between the groups.
Retinal abnormalities in early AD include a specific pattern of RNFL loss, narrow veins, and decreased retinal blood flow in these veins. The results show that AD produces quantifiable abnormalities in the retina.</description><identifier>ISSN: 0146-0404</identifier><identifier>ISSN: 1552-5783</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.06-1029</identifier><identifier>PMID: 17460292</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Adult and adolescent clinical studies ; Aged ; Alzheimer Disease - complications ; Alzheimer Disease - diagnosis ; Alzheimer Disease - physiopathology ; Biological and medical sciences ; Blood Flow Velocity ; Cross-Sectional Studies ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Humans ; Laser-Doppler Flowmetry ; Medical sciences ; Mental Status Schedule ; Nerve Fibers - pathology ; Neurology ; Organic mental disorders. Neuropsychology ; Prospective Studies ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Regional Blood Flow ; Retinal Diseases - diagnosis ; Retinal Diseases - etiology ; Retinal Diseases - physiopathology ; Retinal Ganglion Cells - pathology ; Retinal Vein - physiology ; Tomography, Optical Coherence ; Vertebrates: nervous system and sense organs ; Vision Disorders - diagnosis ; Vision Disorders - etiology ; Vision Disorders - physiopathology</subject><ispartof>Investigative ophthalmology & visual science, 2007-05, Vol.48 (5), p.2285-2289</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-1ae3b38b8dd17cc8cdc13222f6a438d22fe5e7625918ef3e5732f1c70610d2563</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18715975$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17460292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berisha, Fatmire</creatorcontrib><creatorcontrib>Feke, Gilbert T</creatorcontrib><creatorcontrib>Trempe, Clement L</creatorcontrib><creatorcontrib>McMeel, J. Wallace</creatorcontrib><creatorcontrib>Schepens, Charles L</creatorcontrib><title>Retinal Abnormalities in Early Alzheimer's Disease</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>There is evidence suggesting that visual disturbances in patients with Alzheimer's Disease (AD) are due to pathologic changes in the retina and optic nerve, as well as to higher cortical impairment. The purpose of this study was to evaluate retinal hemodynamic parameters and to characterize patterns of retinal nerve fiber layer (RNFL) loss in patients with early AD.
Nine patients with mild to moderate probable AD (mean Mini Mental State Examination score 24 of a possible 30 (age 74.3 +/- 3.3 years; mean +/- SD) and eight age-matched control subjects (age, 74.3 +/- 5.8 years) were included in this prospective cross-sectional study. Blood column diameter, blood velocity, and blood flow rate were measured in the major superior temporal retinal vein in each subject by using a laser Doppler instrument. Peripapillary RNFL was measured by optical coherence tomography.
Patients with AD showed a significant narrowing of the venous blood column diameter (131.7 +/- 10.8 microm) compared with control subjects (148.3 +/- 12.7 microm, P = 0.01), and a significantly reduced venous blood flow rate (9.7 +/- 3.1 microL/min) compared with the control subjects (15.9 +/- 3.7 microL/min, P = 0.002). A significant thinning of the RNFL was found in the superior quadrant in patients with AD (92.2 +/- 21.6 microm) compared with control subjects (113.6 +/- 10.7 microm, P = 0.02). There were no significant differences in the inferior, temporal, or nasal RNFL thicknesses between the groups.
Retinal abnormalities in early AD include a specific pattern of RNFL loss, narrow veins, and decreased retinal blood flow in these veins. The results show that AD produces quantifiable abnormalities in the retina.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Cross-Sectional Studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Laser-Doppler Flowmetry</subject><subject>Medical sciences</subject><subject>Mental Status Schedule</subject><subject>Nerve Fibers - pathology</subject><subject>Neurology</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Prospective Studies</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Regional Blood Flow</subject><subject>Retinal Diseases - diagnosis</subject><subject>Retinal Diseases - etiology</subject><subject>Retinal Diseases - physiopathology</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Retinal Vein - physiology</subject><subject>Tomography, Optical Coherence</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vision Disorders - diagnosis</subject><subject>Vision Disorders - etiology</subject><subject>Vision Disorders - physiopathology</subject><issn>0146-0404</issn><issn>1552-5783</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0EtLAzEUhuEgiq3VnWuZjbpxak4yuXRZar1AQRBdhzRzxkYyM5q0lvrrndJCV8ni4ePwEnIJdAgg1b1vf9OQyhwoGx2RPgjBcqE0PyZ9CoXMaUGLHjlL6YtSBsDoKemBKmTHWZ-wN1z6xoZsPG_aWNvglx5T5ptsamPYZOPwt0BfY7xN2YNPaBOek5PKhoQX-3dAPh6n75PnfPb69DIZz3LHtV7mYJHPuZ7rsgTlnHalA84Yq6QtuC67DwpUkokRaKw4CsVZBU5RCbRkQvIBudntfsf2Z4VpaWqfHIZgG2xXyShaMCEK1sG7HXSxTSliZb6jr23cGKBm28hsGxkqzbZRx6_2u6t5jeUB76N04HoPbHI2VNE2zqeD0wrESInDgQv_uVj7iCZ1AUM3C2a9XhfaCMOYFvwfDkh7Hw</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Berisha, Fatmire</creator><creator>Feke, Gilbert T</creator><creator>Trempe, Clement L</creator><creator>McMeel, J. Wallace</creator><creator>Schepens, Charles L</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Retinal Abnormalities in Early Alzheimer's Disease</title><author>Berisha, Fatmire ; Feke, Gilbert T ; Trempe, Clement L ; McMeel, J. Wallace ; Schepens, Charles L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-1ae3b38b8dd17cc8cdc13222f6a438d22fe5e7625918ef3e5732f1c70610d2563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Alzheimer Disease - complications</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Cross-Sectional Studies</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Laser-Doppler Flowmetry</topic><topic>Medical sciences</topic><topic>Mental Status Schedule</topic><topic>Nerve Fibers - pathology</topic><topic>Neurology</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Prospective Studies</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Regional Blood Flow</topic><topic>Retinal Diseases - diagnosis</topic><topic>Retinal Diseases - etiology</topic><topic>Retinal Diseases - physiopathology</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Retinal Vein - physiology</topic><topic>Tomography, Optical Coherence</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Vision Disorders - diagnosis</topic><topic>Vision Disorders - etiology</topic><topic>Vision Disorders - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berisha, Fatmire</creatorcontrib><creatorcontrib>Feke, Gilbert T</creatorcontrib><creatorcontrib>Trempe, Clement L</creatorcontrib><creatorcontrib>McMeel, J. Wallace</creatorcontrib><creatorcontrib>Schepens, Charles L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berisha, Fatmire</au><au>Feke, Gilbert T</au><au>Trempe, Clement L</au><au>McMeel, J. Wallace</au><au>Schepens, Charles L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal Abnormalities in Early Alzheimer's Disease</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>48</volume><issue>5</issue><spage>2285</spage><epage>2289</epage><pages>2285-2289</pages><issn>0146-0404</issn><issn>1552-5783</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>There is evidence suggesting that visual disturbances in patients with Alzheimer's Disease (AD) are due to pathologic changes in the retina and optic nerve, as well as to higher cortical impairment. The purpose of this study was to evaluate retinal hemodynamic parameters and to characterize patterns of retinal nerve fiber layer (RNFL) loss in patients with early AD.
Nine patients with mild to moderate probable AD (mean Mini Mental State Examination score 24 of a possible 30 (age 74.3 +/- 3.3 years; mean +/- SD) and eight age-matched control subjects (age, 74.3 +/- 5.8 years) were included in this prospective cross-sectional study. Blood column diameter, blood velocity, and blood flow rate were measured in the major superior temporal retinal vein in each subject by using a laser Doppler instrument. Peripapillary RNFL was measured by optical coherence tomography.
Patients with AD showed a significant narrowing of the venous blood column diameter (131.7 +/- 10.8 microm) compared with control subjects (148.3 +/- 12.7 microm, P = 0.01), and a significantly reduced venous blood flow rate (9.7 +/- 3.1 microL/min) compared with the control subjects (15.9 +/- 3.7 microL/min, P = 0.002). A significant thinning of the RNFL was found in the superior quadrant in patients with AD (92.2 +/- 21.6 microm) compared with control subjects (113.6 +/- 10.7 microm, P = 0.02). There were no significant differences in the inferior, temporal, or nasal RNFL thicknesses between the groups.
Retinal abnormalities in early AD include a specific pattern of RNFL loss, narrow veins, and decreased retinal blood flow in these veins. The results show that AD produces quantifiable abnormalities in the retina.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>17460292</pmid><doi>10.1167/iovs.06-1029</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult and adolescent clinical studies Aged Alzheimer Disease - complications Alzheimer Disease - diagnosis Alzheimer Disease - physiopathology Biological and medical sciences Blood Flow Velocity Cross-Sectional Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Humans Laser-Doppler Flowmetry Medical sciences Mental Status Schedule Nerve Fibers - pathology Neurology Organic mental disorders. Neuropsychology Prospective Studies Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Regional Blood Flow Retinal Diseases - diagnosis Retinal Diseases - etiology Retinal Diseases - physiopathology Retinal Ganglion Cells - pathology Retinal Vein - physiology Tomography, Optical Coherence Vertebrates: nervous system and sense organs Vision Disorders - diagnosis Vision Disorders - etiology Vision Disorders - physiopathology |
| title | Retinal Abnormalities in Early Alzheimer's Disease |
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