Tartrate-resistant acid phosphatase 5b (TRAP 5b) as a marker of osteoclast activity in the early phase after cementless total hip replacement
Background After total hip replacement, increased bone metabolism is seen. A local periprosthetic osteopenia can be measured by dual-energy X-ray absorptiometry (DXA), but it is still unkown whether biochemical markers can be used to monitor the local remodeling at an earlier stage. Patients and met...
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| Veröffentlicht in: | Acta orthopaedica 2007-01, Vol.78 (2), p.221-225 |
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| creator | Habermann, Bjoern Eberhardt, Christian Feld, Matthias Zichner, Ludwig A Kurth, Andreas |
| description | Background After total hip replacement, increased bone metabolism is seen. A local periprosthetic osteopenia can be measured by dual-energy X-ray absorptiometry (DXA), but it is still unkown whether biochemical markers can be used to monitor the local remodeling at an earlier stage.
Patients and methods In this prospective study we compared the biochemical markers tartrate-resistant acid phosphatase 5b (TRAP 5b), bone ALP, osteocalcin and CrossLaps with periprosthetic DXA in 17 consecutive patients after uncemented total hip replacement.
Results We found a highly significant early increase in TRAP 5b after 2 weeks and 6 weeks, which was followed by a densitometrically detectable decrease in bone mineral density after 26 weeks, especially in periprosthetic section Gruen zone 7. Bone ALP and osteocalcin levels as markers of osteoblast activity, and also Cross-Laps as a further marker of osteoclast activity, did not appear to allow any significant prediction of local bone remodeling.
Discussion Our findings show that TRAP 5b is a sensitive parameter for monitoring of osteoclast activity after cementless total hip replacement, and may predict local osteopenia. |
| doi_str_mv | 10.1080/17453670710013717 |
| format | Article |
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Patients and methods In this prospective study we compared the biochemical markers tartrate-resistant acid phosphatase 5b (TRAP 5b), bone ALP, osteocalcin and CrossLaps with periprosthetic DXA in 17 consecutive patients after uncemented total hip replacement.
Results We found a highly significant early increase in TRAP 5b after 2 weeks and 6 weeks, which was followed by a densitometrically detectable decrease in bone mineral density after 26 weeks, especially in periprosthetic section Gruen zone 7. Bone ALP and osteocalcin levels as markers of osteoblast activity, and also Cross-Laps as a further marker of osteoclast activity, did not appear to allow any significant prediction of local bone remodeling.
Discussion Our findings show that TRAP 5b is a sensitive parameter for monitoring of osteoclast activity after cementless total hip replacement, and may predict local osteopenia.</description><identifier>ISSN: 1745-3674</identifier><identifier>EISSN: 1745-3682</identifier><identifier>DOI: 10.1080/17453670710013717</identifier><identifier>PMID: 17464610</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Acid Phosphatase - analysis ; Adult ; Aged ; Alkaline Phosphatase - analysis ; Arthroplasty, Replacement, Hip - adverse effects ; Arthroplasty, Replacement, Hip - methods ; Biomarkers - analysis ; Bone Density ; Bone Remodeling ; Bone Resorption ; Female ; Humans ; Male ; Middle Aged ; Osteocalcin - analysis ; Osteoclasts - enzymology ; Prospective Studies ; Prosthesis Failure ; Tartrates</subject><ispartof>Acta orthopaedica, 2007-01, Vol.78 (2), p.221-225</ispartof><rights>2007 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-13cb1c8b368d75ffec8532d67ae74d18490bca83f8007495c63923ebf7faaa8a3</citedby><cites>FETCH-LOGICAL-c493t-13cb1c8b368d75ffec8532d67ae74d18490bca83f8007495c63923ebf7faaa8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17464610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Habermann, Bjoern</creatorcontrib><creatorcontrib>Eberhardt, Christian</creatorcontrib><creatorcontrib>Feld, Matthias</creatorcontrib><creatorcontrib>Zichner, Ludwig</creatorcontrib><creatorcontrib>A Kurth, Andreas</creatorcontrib><title>Tartrate-resistant acid phosphatase 5b (TRAP 5b) as a marker of osteoclast activity in the early phase after cementless total hip replacement</title><title>Acta orthopaedica</title><addtitle>Acta Orthop</addtitle><description>Background After total hip replacement, increased bone metabolism is seen. A local periprosthetic osteopenia can be measured by dual-energy X-ray absorptiometry (DXA), but it is still unkown whether biochemical markers can be used to monitor the local remodeling at an earlier stage.
Patients and methods In this prospective study we compared the biochemical markers tartrate-resistant acid phosphatase 5b (TRAP 5b), bone ALP, osteocalcin and CrossLaps with periprosthetic DXA in 17 consecutive patients after uncemented total hip replacement.
Results We found a highly significant early increase in TRAP 5b after 2 weeks and 6 weeks, which was followed by a densitometrically detectable decrease in bone mineral density after 26 weeks, especially in periprosthetic section Gruen zone 7. Bone ALP and osteocalcin levels as markers of osteoblast activity, and also Cross-Laps as a further marker of osteoclast activity, did not appear to allow any significant prediction of local bone remodeling.
Discussion Our findings show that TRAP 5b is a sensitive parameter for monitoring of osteoclast activity after cementless total hip replacement, and may predict local osteopenia.</description><subject>Acid Phosphatase - analysis</subject><subject>Adult</subject><subject>Aged</subject><subject>Alkaline Phosphatase - analysis</subject><subject>Arthroplasty, Replacement, Hip - adverse effects</subject><subject>Arthroplasty, Replacement, Hip - methods</subject><subject>Biomarkers - analysis</subject><subject>Bone Density</subject><subject>Bone Remodeling</subject><subject>Bone Resorption</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osteocalcin - analysis</subject><subject>Osteoclasts - enzymology</subject><subject>Prospective Studies</subject><subject>Prosthesis Failure</subject><subject>Tartrates</subject><issn>1745-3674</issn><issn>1745-3682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-KFDEQxhtR3HX1AbxITqKH1mSS7vTgXpbFf7CgyHgO1ekKnTXdaVMZZR7CdzbNDIoIe0qR-r4f9VVV1VPBXwne8ddCq0a2mmvBuZBa6HvV-fpXy7bb3P9Ta3VWPSK65Vx2assfVmel0apW8PPq1w5STpCxTkieMsyZgfUDW8ZIywgZCFnTsxe7L1efS_GSATFgE6RvmFh0LFLGaAPQ6sv-h88H5meWR2QIKRwKaEWAy0VvccI5ByRiOWYIbPQLS7gEOHYeVw8cBMInp_ei-vru7e76Q33z6f3H66ub2qqtzLWQthe260vMQTfOoe0auRlaDajVINaQvYVOuo5zrbaNbeV2I7F32gFAB_Kien7kLil-3yNlM3myGALMGPdkNFebRilehOIotCkSJXRmSb6EPxjBzXoD898NiufZCb7vJxz-Ok5LL4LLo8DPLqYJfsYUBpPhEGJyCWbryci7-G_-sY8IIY8WEprbuE9zWdwd0_0GIryoew</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Habermann, Bjoern</creator><creator>Eberhardt, Christian</creator><creator>Feld, Matthias</creator><creator>Zichner, Ludwig</creator><creator>A Kurth, Andreas</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Tartrate-resistant acid phosphatase 5b (TRAP 5b) as a marker of osteoclast activity in the early phase after cementless total hip replacement</title><author>Habermann, Bjoern ; Eberhardt, Christian ; Feld, Matthias ; Zichner, Ludwig ; A Kurth, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-13cb1c8b368d75ffec8532d67ae74d18490bca83f8007495c63923ebf7faaa8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acid Phosphatase - analysis</topic><topic>Adult</topic><topic>Aged</topic><topic>Alkaline Phosphatase - analysis</topic><topic>Arthroplasty, Replacement, Hip - adverse effects</topic><topic>Arthroplasty, Replacement, Hip - methods</topic><topic>Biomarkers - analysis</topic><topic>Bone Density</topic><topic>Bone Remodeling</topic><topic>Bone Resorption</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Osteocalcin - analysis</topic><topic>Osteoclasts - enzymology</topic><topic>Prospective Studies</topic><topic>Prosthesis Failure</topic><topic>Tartrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Habermann, Bjoern</creatorcontrib><creatorcontrib>Eberhardt, Christian</creatorcontrib><creatorcontrib>Feld, Matthias</creatorcontrib><creatorcontrib>Zichner, Ludwig</creatorcontrib><creatorcontrib>A Kurth, Andreas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta orthopaedica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Habermann, Bjoern</au><au>Eberhardt, Christian</au><au>Feld, Matthias</au><au>Zichner, Ludwig</au><au>A Kurth, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tartrate-resistant acid phosphatase 5b (TRAP 5b) as a marker of osteoclast activity in the early phase after cementless total hip replacement</atitle><jtitle>Acta orthopaedica</jtitle><addtitle>Acta Orthop</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>78</volume><issue>2</issue><spage>221</spage><epage>225</epage><pages>221-225</pages><issn>1745-3674</issn><eissn>1745-3682</eissn><abstract>Background After total hip replacement, increased bone metabolism is seen. A local periprosthetic osteopenia can be measured by dual-energy X-ray absorptiometry (DXA), but it is still unkown whether biochemical markers can be used to monitor the local remodeling at an earlier stage.
Patients and methods In this prospective study we compared the biochemical markers tartrate-resistant acid phosphatase 5b (TRAP 5b), bone ALP, osteocalcin and CrossLaps with periprosthetic DXA in 17 consecutive patients after uncemented total hip replacement.
Results We found a highly significant early increase in TRAP 5b after 2 weeks and 6 weeks, which was followed by a densitometrically detectable decrease in bone mineral density after 26 weeks, especially in periprosthetic section Gruen zone 7. Bone ALP and osteocalcin levels as markers of osteoblast activity, and also Cross-Laps as a further marker of osteoclast activity, did not appear to allow any significant prediction of local bone remodeling.
Discussion Our findings show that TRAP 5b is a sensitive parameter for monitoring of osteoclast activity after cementless total hip replacement, and may predict local osteopenia.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>17464610</pmid><doi>10.1080/17453670710013717</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acid Phosphatase - analysis Adult Aged Alkaline Phosphatase - analysis Arthroplasty, Replacement, Hip - adverse effects Arthroplasty, Replacement, Hip - methods Biomarkers - analysis Bone Density Bone Remodeling Bone Resorption Female Humans Male Middle Aged Osteocalcin - analysis Osteoclasts - enzymology Prospective Studies Prosthesis Failure Tartrates |
| title | Tartrate-resistant acid phosphatase 5b (TRAP 5b) as a marker of osteoclast activity in the early phase after cementless total hip replacement |
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