TNFalpha-308G/A polymorphism as a risk factor for HPV associated cervical cancer in Indian population
Investigation of the potential association of single nucleotide polymorphisms (SNPs) at -308 G/A and -238 G/A of Tumor necrosis factor alpha (TNFalpha) with susceptibility to HPV-16 associated cervical cancer in Indian women. The study included 165 histologically confirmed cases with 45 precancer an...
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| Veröffentlicht in: | Cellular oncology : the official journal of the International Society for Cellular Oncology 2007, Vol.29 (3), p.249-256 |
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| container_title | Cellular oncology : the official journal of the International Society for Cellular Oncology |
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| creator | Kohaar, Indu Thakur, Nisha Salhan, Sudha Batra, Swaraj Singh, Veena Sharma, Anita Sodhani, Pushpa Das, B C Sarkar, Debi P Bharadwaj, Mausumi |
| description | Investigation of the potential association of single nucleotide polymorphisms (SNPs) at -308 G/A and -238 G/A of Tumor necrosis factor alpha (TNFalpha) with susceptibility to HPV-16 associated cervical cancer in Indian women.
The study included 165 histologically confirmed cases with 45 precancer and 120 cancer patients and an equal number (165) of healthy controls with normal cervical cytology. PCR-RFLP was employed to analyze TNFalpha promoter polymorphisms, which were confirmed by direct sequencing. Both patients and controls were screened for Human Papillomavirus (HPV) infection.
The frequency of -308 A allele in TNFalpha was significantly higher in cases compared with control subjects (21% in cases vs. 9% in controls; p |
| format | Article |
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The study included 165 histologically confirmed cases with 45 precancer and 120 cancer patients and an equal number (165) of healthy controls with normal cervical cytology. PCR-RFLP was employed to analyze TNFalpha promoter polymorphisms, which were confirmed by direct sequencing. Both patients and controls were screened for Human Papillomavirus (HPV) infection.
The frequency of -308 A allele in TNFalpha was significantly higher in cases compared with control subjects (21% in cases vs. 9% in controls; p<0.01), with an odds ratio of 2.7 (95% CI = 1.41-5.15). Also, women carrying A allele for this locus presented 3 times increased susceptibility to HPV 16 infection as evident from carrier genotype distribution between HPV positive cases and control subjects (24% in HPV positive cases vs. 9% in controls; p<0.01; OR = 3.1; 95% CI = 1.60-6.03). No such association was found for TNFalpha-238 (G/A) polymorphism with the risk of development of cervical cancer.
It suggests that SNP at -308 (G/A) of TNFalpha promoter may represent an increased risk for HPV infection and development of cervical cancer in Indian women.</description><identifier>ISSN: 1570-5870</identifier><identifier>PMID: 17452777</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Adenine ; Base Sequence ; Case-Control Studies ; DNA Mutational Analysis ; European Continental Ancestry Group - genetics ; Female ; Genetic Predisposition to Disease - genetics ; Genotype ; Guanine ; Human papillomavirus 16 - physiology ; Humans ; India - epidemiology ; Middle Aged ; Molecular Sequence Data ; Polymorphism, Single Nucleotide - genetics ; Precancerous Conditions - genetics ; Prevalence ; Promoter Regions, Genetic - genetics ; Tumor Necrosis Factor-alpha - genetics ; Uterine Cervical Neoplasms - epidemiology ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - virology</subject><ispartof>Cellular oncology : the official journal of the International Society for Cellular Oncology, 2007, Vol.29 (3), p.249-256</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17452777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kohaar, Indu</creatorcontrib><creatorcontrib>Thakur, Nisha</creatorcontrib><creatorcontrib>Salhan, Sudha</creatorcontrib><creatorcontrib>Batra, Swaraj</creatorcontrib><creatorcontrib>Singh, Veena</creatorcontrib><creatorcontrib>Sharma, Anita</creatorcontrib><creatorcontrib>Sodhani, Pushpa</creatorcontrib><creatorcontrib>Das, B C</creatorcontrib><creatorcontrib>Sarkar, Debi P</creatorcontrib><creatorcontrib>Bharadwaj, Mausumi</creatorcontrib><title>TNFalpha-308G/A polymorphism as a risk factor for HPV associated cervical cancer in Indian population</title><title>Cellular oncology : the official journal of the International Society for Cellular Oncology</title><addtitle>Cell Oncol</addtitle><description>Investigation of the potential association of single nucleotide polymorphisms (SNPs) at -308 G/A and -238 G/A of Tumor necrosis factor alpha (TNFalpha) with susceptibility to HPV-16 associated cervical cancer in Indian women.
The study included 165 histologically confirmed cases with 45 precancer and 120 cancer patients and an equal number (165) of healthy controls with normal cervical cytology. PCR-RFLP was employed to analyze TNFalpha promoter polymorphisms, which were confirmed by direct sequencing. Both patients and controls were screened for Human Papillomavirus (HPV) infection.
The frequency of -308 A allele in TNFalpha was significantly higher in cases compared with control subjects (21% in cases vs. 9% in controls; p<0.01), with an odds ratio of 2.7 (95% CI = 1.41-5.15). Also, women carrying A allele for this locus presented 3 times increased susceptibility to HPV 16 infection as evident from carrier genotype distribution between HPV positive cases and control subjects (24% in HPV positive cases vs. 9% in controls; p<0.01; OR = 3.1; 95% CI = 1.60-6.03). No such association was found for TNFalpha-238 (G/A) polymorphism with the risk of development of cervical cancer.
It suggests that SNP at -308 (G/A) of TNFalpha promoter may represent an increased risk for HPV infection and development of cervical cancer in Indian women.</description><subject>Adenine</subject><subject>Base Sequence</subject><subject>Case-Control Studies</subject><subject>DNA Mutational Analysis</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Guanine</subject><subject>Human papillomavirus 16 - physiology</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Precancerous Conditions - genetics</subject><subject>Prevalence</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Uterine Cervical Neoplasms - epidemiology</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - virology</subject><issn>1570-5870</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kD1PwzAYhD2AaCn8BeSJLeKNHdftWFX0Q6qAoWKN3vhDNTixsROk_nuCKMPpTrpHN9wVmZZCQiEWEibkNucPAM6qEm7IpJSVYFLKKTHHlw36eMKCw2L7tKIx-HMbUjy53FLMFGly-ZNaVH1I1I7avb2PRQ7KYW80VSZ9O4WeKuzGTF1H95122I1TcfDYu9DdkWuLPpv7i8_IcfN8XO-Kw-t2v14diigqWaiG20ZotByFslwgsmrOwaIuEbhaMm6xZA0oKSzCfK5NpWBhlNZaMamBz8jj32xM4Wswua9bl5XxHjsThlxLqJhgy1_w4QIOTWt0HZNrMZ3r_1_4D0FyXt0</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>Kohaar, Indu</creator><creator>Thakur, Nisha</creator><creator>Salhan, Sudha</creator><creator>Batra, Swaraj</creator><creator>Singh, Veena</creator><creator>Sharma, Anita</creator><creator>Sodhani, Pushpa</creator><creator>Das, B C</creator><creator>Sarkar, Debi P</creator><creator>Bharadwaj, Mausumi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2007</creationdate><title>TNFalpha-308G/A polymorphism as a risk factor for HPV associated cervical cancer in Indian population</title><author>Kohaar, Indu ; Thakur, Nisha ; Salhan, Sudha ; Batra, Swaraj ; Singh, Veena ; Sharma, Anita ; Sodhani, Pushpa ; Das, B C ; Sarkar, Debi P ; Bharadwaj, Mausumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p547-cb3fb5daf3a5cf35aa24630fad1a03c923fa12b0c75fa066de4c08ecdddc27d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenine</topic><topic>Base Sequence</topic><topic>Case-Control Studies</topic><topic>DNA Mutational Analysis</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Guanine</topic><topic>Human papillomavirus 16 - physiology</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Precancerous Conditions - genetics</topic><topic>Prevalence</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Uterine Cervical Neoplasms - epidemiology</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - virology</topic><toplevel>online_resources</toplevel><creatorcontrib>Kohaar, Indu</creatorcontrib><creatorcontrib>Thakur, Nisha</creatorcontrib><creatorcontrib>Salhan, Sudha</creatorcontrib><creatorcontrib>Batra, Swaraj</creatorcontrib><creatorcontrib>Singh, Veena</creatorcontrib><creatorcontrib>Sharma, Anita</creatorcontrib><creatorcontrib>Sodhani, Pushpa</creatorcontrib><creatorcontrib>Das, B C</creatorcontrib><creatorcontrib>Sarkar, Debi P</creatorcontrib><creatorcontrib>Bharadwaj, Mausumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular oncology : the official journal of the International Society for Cellular Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kohaar, Indu</au><au>Thakur, Nisha</au><au>Salhan, Sudha</au><au>Batra, Swaraj</au><au>Singh, Veena</au><au>Sharma, Anita</au><au>Sodhani, Pushpa</au><au>Das, B C</au><au>Sarkar, Debi P</au><au>Bharadwaj, Mausumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TNFalpha-308G/A polymorphism as a risk factor for HPV associated cervical cancer in Indian population</atitle><jtitle>Cellular oncology : the official journal of the International Society for Cellular Oncology</jtitle><addtitle>Cell Oncol</addtitle><date>2007</date><risdate>2007</risdate><volume>29</volume><issue>3</issue><spage>249</spage><epage>256</epage><pages>249-256</pages><issn>1570-5870</issn><abstract>Investigation of the potential association of single nucleotide polymorphisms (SNPs) at -308 G/A and -238 G/A of Tumor necrosis factor alpha (TNFalpha) with susceptibility to HPV-16 associated cervical cancer in Indian women.
The study included 165 histologically confirmed cases with 45 precancer and 120 cancer patients and an equal number (165) of healthy controls with normal cervical cytology. PCR-RFLP was employed to analyze TNFalpha promoter polymorphisms, which were confirmed by direct sequencing. Both patients and controls were screened for Human Papillomavirus (HPV) infection.
The frequency of -308 A allele in TNFalpha was significantly higher in cases compared with control subjects (21% in cases vs. 9% in controls; p<0.01), with an odds ratio of 2.7 (95% CI = 1.41-5.15). Also, women carrying A allele for this locus presented 3 times increased susceptibility to HPV 16 infection as evident from carrier genotype distribution between HPV positive cases and control subjects (24% in HPV positive cases vs. 9% in controls; p<0.01; OR = 3.1; 95% CI = 1.60-6.03). No such association was found for TNFalpha-238 (G/A) polymorphism with the risk of development of cervical cancer.
It suggests that SNP at -308 (G/A) of TNFalpha promoter may represent an increased risk for HPV infection and development of cervical cancer in Indian women.</abstract><cop>Netherlands</cop><pmid>17452777</pmid><tpages>8</tpages></addata></record> |
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| subjects | Adenine Base Sequence Case-Control Studies DNA Mutational Analysis European Continental Ancestry Group - genetics Female Genetic Predisposition to Disease - genetics Genotype Guanine Human papillomavirus 16 - physiology Humans India - epidemiology Middle Aged Molecular Sequence Data Polymorphism, Single Nucleotide - genetics Precancerous Conditions - genetics Prevalence Promoter Regions, Genetic - genetics Tumor Necrosis Factor-alpha - genetics Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - virology |
| title | TNFalpha-308G/A polymorphism as a risk factor for HPV associated cervical cancer in Indian population |
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