The effect of locally applied vascular endothelial growth factor on meniscus healing: gross and histological findings
Tears in the peripheral part of the menisci have a better healing potential than tears in the central part, because the central two-thirds of the menisci are avascular. We hypothesized that healing of meniscus tears in the avascular zone can be promoted by the local application of the angiogenic fac...
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| Veröffentlicht in: | Archives of orthopaedic and trauma surgery 2007-05, Vol.127 (4), p.235-240 |
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| container_title | Archives of orthopaedic and trauma surgery |
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| creator | Petersen, Wolf Pufe, Thomas Stärke, Christian Fuchs, Thomas Kopf, Sebastian Neumann, Wolfram Zantop, Thore Paletta, Juergen Raschke, Michael Becker, Roland |
| description | Tears in the peripheral part of the menisci have a better healing potential than tears in the central part, because the central two-thirds of the menisci are avascular. We hypothesized that healing of meniscus tears in the avascular zone can be promoted by the local application of the angiogenic factor vascular endothelial growth factor (VEGF).
A tear was created in the avascular zone of the medial meniscus in 18 merino sheep. The tear was then repaired with an uncoated suture (group 1), a suture coated with PDLLA (group 2), and by a suture coated with PDLLA/VEGF (group 3).
After 6 weeks, we observed increased immunostaining for factor VIII in the VEGF-treated group 3. However, in this treatment group no meniscus healed completely. In the uncoated suture group and in the PDLLA-coated-suture group, partial healing was observed in three animals and complete healing in three animals, respectively.
In this experiment the local application of VEGF via PDLLA-coated sutures did not promote meniscus healing. Growth factors might not always be a promising tool for tissue repair. |
| doi_str_mv | 10.1007/s00402-005-0024-2 |
| format | Article |
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A tear was created in the avascular zone of the medial meniscus in 18 merino sheep. The tear was then repaired with an uncoated suture (group 1), a suture coated with PDLLA (group 2), and by a suture coated with PDLLA/VEGF (group 3).
After 6 weeks, we observed increased immunostaining for factor VIII in the VEGF-treated group 3. However, in this treatment group no meniscus healed completely. In the uncoated suture group and in the PDLLA-coated-suture group, partial healing was observed in three animals and complete healing in three animals, respectively.
In this experiment the local application of VEGF via PDLLA-coated sutures did not promote meniscus healing. Growth factors might not always be a promising tool for tissue repair.</description><identifier>ISSN: 0936-8051</identifier><identifier>EISSN: 1434-3916</identifier><identifier>DOI: 10.1007/s00402-005-0024-2</identifier><identifier>PMID: 16896747</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Animals ; Coated Materials, Biocompatible ; Factor VIII - analysis ; Female ; Immunoenzyme Techniques ; Lactic Acid ; Menisci, Tibial - pathology ; Menisci, Tibial - surgery ; Polyesters ; Polyethylene Terephthalates ; Polymers ; Sheep ; Sutures ; Tibial Meniscus Injuries ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - pharmacology ; Wound Healing - drug effects</subject><ispartof>Archives of orthopaedic and trauma surgery, 2007-05, Vol.127 (4), p.235-240</ispartof><rights>Springer-Verlag 2006.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-1782305320e601eae302e9739e392795aff087f17edd09dee4636c130b8fea883</citedby><cites>FETCH-LOGICAL-c393t-1782305320e601eae302e9739e392795aff087f17edd09dee4636c130b8fea883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16896747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petersen, Wolf</creatorcontrib><creatorcontrib>Pufe, Thomas</creatorcontrib><creatorcontrib>Stärke, Christian</creatorcontrib><creatorcontrib>Fuchs, Thomas</creatorcontrib><creatorcontrib>Kopf, Sebastian</creatorcontrib><creatorcontrib>Neumann, Wolfram</creatorcontrib><creatorcontrib>Zantop, Thore</creatorcontrib><creatorcontrib>Paletta, Juergen</creatorcontrib><creatorcontrib>Raschke, Michael</creatorcontrib><creatorcontrib>Becker, Roland</creatorcontrib><title>The effect of locally applied vascular endothelial growth factor on meniscus healing: gross and histological findings</title><title>Archives of orthopaedic and trauma surgery</title><addtitle>Arch Orthop Trauma Surg</addtitle><description>Tears in the peripheral part of the menisci have a better healing potential than tears in the central part, because the central two-thirds of the menisci are avascular. We hypothesized that healing of meniscus tears in the avascular zone can be promoted by the local application of the angiogenic factor vascular endothelial growth factor (VEGF).
A tear was created in the avascular zone of the medial meniscus in 18 merino sheep. The tear was then repaired with an uncoated suture (group 1), a suture coated with PDLLA (group 2), and by a suture coated with PDLLA/VEGF (group 3).
After 6 weeks, we observed increased immunostaining for factor VIII in the VEGF-treated group 3. However, in this treatment group no meniscus healed completely. In the uncoated suture group and in the PDLLA-coated-suture group, partial healing was observed in three animals and complete healing in three animals, respectively.
In this experiment the local application of VEGF via PDLLA-coated sutures did not promote meniscus healing. Growth factors might not always be a promising tool for tissue repair.</description><subject>Animals</subject><subject>Coated Materials, Biocompatible</subject><subject>Factor VIII - analysis</subject><subject>Female</subject><subject>Immunoenzyme Techniques</subject><subject>Lactic Acid</subject><subject>Menisci, Tibial - pathology</subject><subject>Menisci, Tibial - surgery</subject><subject>Polyesters</subject><subject>Polyethylene Terephthalates</subject><subject>Polymers</subject><subject>Sheep</subject><subject>Sutures</subject><subject>Tibial Meniscus Injuries</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - pharmacology</subject><subject>Wound Healing - drug effects</subject><issn>0936-8051</issn><issn>1434-3916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU1LxDAQhoMo7rr6A7xIQPBWnSRt0ngT8QsEL3oOsZ1su2SbtWmV_fem7ILgYchhnnmZyUPIOYNrBqBuIkAOPAMoUvE84wdkznKRZ0IzeUjmoIXMSijYjJzEuAJgvNRwTGZMllqqXM3J-N4gReewGmhw1IfKer-ldrPxLdb028Zq9Lan2NVhaNC31tNlH36GhjpbDaGnoaNr7NrERdqg9W23vJ2QGKntatq0cQg-LNsUTF3b1akfT8mRsz7i2f5dkI_Hh_f75-z17enl_u41q4QWQ8ZUyQUUggNKYGhRAEethEahudKFdQ5K5ZjCugZdI-ZSyIoJ-Cwd2rIUC3K1y9304WvEOJh1WhS9tx2GMRoFOc9F-rIFufwHrsLYd2k3w7lkWgMrZKLYjqqm83p0ZtO3a9tvDQMzGTE7IyYZMZMRw9PMxT55_Fxj_TexVyB-AYGihyY</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Petersen, Wolf</creator><creator>Pufe, Thomas</creator><creator>Stärke, Christian</creator><creator>Fuchs, Thomas</creator><creator>Kopf, Sebastian</creator><creator>Neumann, Wolfram</creator><creator>Zantop, Thore</creator><creator>Paletta, Juergen</creator><creator>Raschke, Michael</creator><creator>Becker, Roland</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>The effect of locally applied vascular endothelial growth factor on meniscus healing: gross and histological findings</title><author>Petersen, Wolf ; 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We hypothesized that healing of meniscus tears in the avascular zone can be promoted by the local application of the angiogenic factor vascular endothelial growth factor (VEGF).
A tear was created in the avascular zone of the medial meniscus in 18 merino sheep. The tear was then repaired with an uncoated suture (group 1), a suture coated with PDLLA (group 2), and by a suture coated with PDLLA/VEGF (group 3).
After 6 weeks, we observed increased immunostaining for factor VIII in the VEGF-treated group 3. However, in this treatment group no meniscus healed completely. In the uncoated suture group and in the PDLLA-coated-suture group, partial healing was observed in three animals and complete healing in three animals, respectively.
In this experiment the local application of VEGF via PDLLA-coated sutures did not promote meniscus healing. Growth factors might not always be a promising tool for tissue repair.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>16896747</pmid><doi>10.1007/s00402-005-0024-2</doi><tpages>6</tpages></addata></record> |
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| ispartof | Archives of orthopaedic and trauma surgery, 2007-05, Vol.127 (4), p.235-240 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Coated Materials, Biocompatible Factor VIII - analysis Female Immunoenzyme Techniques Lactic Acid Menisci, Tibial - pathology Menisci, Tibial - surgery Polyesters Polyethylene Terephthalates Polymers Sheep Sutures Tibial Meniscus Injuries Vascular endothelial growth factor Vascular Endothelial Growth Factor A - pharmacology Wound Healing - drug effects |
| title | The effect of locally applied vascular endothelial growth factor on meniscus healing: gross and histological findings |
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