Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction
Adenosine is analgesic in humans, and the selective adenosine A1 receptor agonist GR79236X has significant anti-nociceptive activity in an animal pain model of inflammatory pain. Seventy-nine patients with moderate pain after third molar extraction under general anaesthesia were randomized to receiv...
Gespeichert in:
| Veröffentlicht in: | British journal of anaesthesia : BJA 2007-05, Vol.98 (5), p.672-676 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 676 |
|---|---|
| container_issue | 5 |
| container_start_page | 672 |
| container_title | British journal of anaesthesia : BJA |
| container_volume | 98 |
| creator | Sneyd, J.R. Langton, J.A. Allan, L.G. Peacock, J.E. Rowbotham, D.J. |
| description | Adenosine is analgesic in humans, and the selective adenosine A1 receptor agonist GR79236X has significant anti-nociceptive activity in an animal pain model of inflammatory pain.
Seventy-nine patients with moderate pain after third molar extraction under general anaesthesia were randomized to receive a 15 min double-blind infusion containing either GR79236X 4 µg kg −1, GR79236X 10 µg kg −1, diclofenac 50 mg, or saline placebo. Rescue analgesia was promptly available to all patients.
Meaningful pain relief (mild or no pain) was attained by 9 (47%) patients in the placebo group, 12 (63%) patients in the GR79236 4 µg kg −1 group, 10 (48%) patients in the 10 µg kg −1 group, and 16 (80%) patients in the diclofenac 50 mg group. Neither dose of GR79236 produced a significant improvement over placebo, but diclofenac was superior to both placebo (P = 0.036) and GR79236 10 µg kg −1 (P = 0.034). Median times to rescue or additional analgesia were 62, 100, 60, and 363 min for patients receiving placebo, GR79236 4 µg kg −1, 10 µg kg −1, and diclofenac 50 mg, respectively (diclofenac significantly longer than placebo, P = 0.002 log-rank test). Pain control was poor in the placebo group and in both GR79236 groups, with between 79 and 86% of patients having good pain control (i.e. mild or no pain) for |
| doi_str_mv | 10.1093/bja/aem075 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70424197</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/bja/aem075</oup_id><els_id>S0007091217348559</els_id><sourcerecordid>1282528441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-d59811b2a6a7dd1d0833b36c02e8a328c5514fcfea190532521f14e6d801cfc3</originalsourceid><addsrcrecordid>eNp90VFrFDEQB_Agij1PX_wAEgR9ENZmNtlk8yhFW7EiaMHSl5DLztqcu5szydb67U3ZwwMRnxIyv8yE_Al5Cuw1MM2PN1t7bHFkqrlHViAUVFIpuE9WjDFVMQ31EXmU0pYxULVuHpIjUAKkZnJF4sd5yN7hlCNSvLHDbLMPEw09zddIbYdTSH4qu29h8inT089K11xeUj_RXbHlZqI_fb6mhWY7lMNSsX3GWDr42NExDDZSvM3Rurvej8mD3g4Jn-zXNbl49_bi5Kw6_3T6_uTNeeWEhlx1jW4BNrWVVnUddKzlfMOlYzW2ltetaxoQvevRgmYNr5saehAou5aB6x1fk5dL210MP2ZM2Yw-ORwGO2GYk1FM1AK0KvD5X3Ab5jiVp5lSVrJWZfSavFqQiyGliL3ZRT_a-MsAM3cpmJKCWVIo-Nm-47wZsTvQ_bcX8GIPbHJ26KOdnE8H1yrJuISDC_Pu_wOrxZWE8PaPtPG7kYqrxpxdXpm2FR_0F3FlvhYvFo_l_288RpNcSdJh5yO6bLrg_zXmN4ffvjM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>197762708</pqid></control><display><type>article</type><title>Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Sneyd, J.R. ; Langton, J.A. ; Allan, L.G. ; Peacock, J.E. ; Rowbotham, D.J.</creator><creatorcontrib>Sneyd, J.R. ; Langton, J.A. ; Allan, L.G. ; Peacock, J.E. ; Rowbotham, D.J.</creatorcontrib><description>Adenosine is analgesic in humans, and the selective adenosine A1 receptor agonist GR79236X has significant anti-nociceptive activity in an animal pain model of inflammatory pain.
Seventy-nine patients with moderate pain after third molar extraction under general anaesthesia were randomized to receive a 15 min double-blind infusion containing either GR79236X 4 µg kg −1, GR79236X 10 µg kg −1, diclofenac 50 mg, or saline placebo. Rescue analgesia was promptly available to all patients.
Meaningful pain relief (mild or no pain) was attained by 9 (47%) patients in the placebo group, 12 (63%) patients in the GR79236 4 µg kg −1 group, 10 (48%) patients in the 10 µg kg −1 group, and 16 (80%) patients in the diclofenac 50 mg group. Neither dose of GR79236 produced a significant improvement over placebo, but diclofenac was superior to both placebo (P = 0.036) and GR79236 10 µg kg −1 (P = 0.034). Median times to rescue or additional analgesia were 62, 100, 60, and 363 min for patients receiving placebo, GR79236 4 µg kg −1, 10 µg kg −1, and diclofenac 50 mg, respectively (diclofenac significantly longer than placebo, P = 0.002 log-rank test). Pain control was poor in the placebo group and in both GR79236 groups, with between 79 and 86% of patients having good pain control (i.e. mild or no pain) for <20% of the time compared with only 30% of patients who received diclofenac.
We found no evidence of efficacy of GR79236 compared with placebo, but the active control diclofenac was effective. It is possible that a higher dose of GR79236 might have been effective or that i.v. administration of this drug does not achieve appropriate concentrations in the brain or peripheral nerves.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/aem075</identifier><identifier>PMID: 17416906</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>acute ; acute pain ; acute pain, novel techniques ; Adenosine - administration & dosage ; Adenosine - analogs & derivatives ; Adenosine - therapeutic use ; Adolescent ; Adult ; anaesthesia ; anaesthesia, dental ; analgesics non-opioid ; analgesics non-opioid, diclofenac ; Analgesics, Non-Narcotic - administration & dosage ; Analgesics, Non-Narcotic - therapeutic use ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Biological and medical sciences ; dental ; diclofenac ; Diclofenac - therapeutic use ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Molar, Third - surgery ; novel techniques ; pain ; Pain Measurement - methods ; pain, acute ; Pain, Postoperative - drug therapy ; Pain, Postoperative - etiology ; Purinergic P1 Receptor Agonists ; Tooth Extraction - adverse effects</subject><ispartof>British journal of anaesthesia : BJA, 2007-05, Vol.98 (5), p.672-676</ispartof><rights>2007 British Journal of Anaesthesia</rights><rights>The Board of Management and Trustees of the British Journal of Anaesthesia 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org 2007</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) May 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-d59811b2a6a7dd1d0833b36c02e8a328c5514fcfea190532521f14e6d801cfc3</citedby><cites>FETCH-LOGICAL-c491t-d59811b2a6a7dd1d0833b36c02e8a328c5514fcfea190532521f14e6d801cfc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18760361$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17416906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sneyd, J.R.</creatorcontrib><creatorcontrib>Langton, J.A.</creatorcontrib><creatorcontrib>Allan, L.G.</creatorcontrib><creatorcontrib>Peacock, J.E.</creatorcontrib><creatorcontrib>Rowbotham, D.J.</creatorcontrib><title>Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><addtitle>Br J Anaesth</addtitle><description>Adenosine is analgesic in humans, and the selective adenosine A1 receptor agonist GR79236X has significant anti-nociceptive activity in an animal pain model of inflammatory pain.
Seventy-nine patients with moderate pain after third molar extraction under general anaesthesia were randomized to receive a 15 min double-blind infusion containing either GR79236X 4 µg kg −1, GR79236X 10 µg kg −1, diclofenac 50 mg, or saline placebo. Rescue analgesia was promptly available to all patients.
Meaningful pain relief (mild or no pain) was attained by 9 (47%) patients in the placebo group, 12 (63%) patients in the GR79236 4 µg kg −1 group, 10 (48%) patients in the 10 µg kg −1 group, and 16 (80%) patients in the diclofenac 50 mg group. Neither dose of GR79236 produced a significant improvement over placebo, but diclofenac was superior to both placebo (P = 0.036) and GR79236 10 µg kg −1 (P = 0.034). Median times to rescue or additional analgesia were 62, 100, 60, and 363 min for patients receiving placebo, GR79236 4 µg kg −1, 10 µg kg −1, and diclofenac 50 mg, respectively (diclofenac significantly longer than placebo, P = 0.002 log-rank test). Pain control was poor in the placebo group and in both GR79236 groups, with between 79 and 86% of patients having good pain control (i.e. mild or no pain) for <20% of the time compared with only 30% of patients who received diclofenac.
We found no evidence of efficacy of GR79236 compared with placebo, but the active control diclofenac was effective. It is possible that a higher dose of GR79236 might have been effective or that i.v. administration of this drug does not achieve appropriate concentrations in the brain or peripheral nerves.</description><subject>acute</subject><subject>acute pain</subject><subject>acute pain, novel techniques</subject><subject>Adenosine - administration & dosage</subject><subject>Adenosine - analogs & derivatives</subject><subject>Adenosine - therapeutic use</subject><subject>Adolescent</subject><subject>Adult</subject><subject>anaesthesia</subject><subject>anaesthesia, dental</subject><subject>analgesics non-opioid</subject><subject>analgesics non-opioid, diclofenac</subject><subject>Analgesics, Non-Narcotic - administration & dosage</subject><subject>Analgesics, Non-Narcotic - therapeutic use</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>dental</subject><subject>diclofenac</subject><subject>Diclofenac - therapeutic use</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molar, Third - surgery</subject><subject>novel techniques</subject><subject>pain</subject><subject>Pain Measurement - methods</subject><subject>pain, acute</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Pain, Postoperative - etiology</subject><subject>Purinergic P1 Receptor Agonists</subject><subject>Tooth Extraction - adverse effects</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90VFrFDEQB_Agij1PX_wAEgR9ENZmNtlk8yhFW7EiaMHSl5DLztqcu5szydb67U3ZwwMRnxIyv8yE_Al5Cuw1MM2PN1t7bHFkqrlHViAUVFIpuE9WjDFVMQ31EXmU0pYxULVuHpIjUAKkZnJF4sd5yN7hlCNSvLHDbLMPEw09zddIbYdTSH4qu29h8inT089K11xeUj_RXbHlZqI_fb6mhWY7lMNSsX3GWDr42NExDDZSvM3Rurvej8mD3g4Jn-zXNbl49_bi5Kw6_3T6_uTNeeWEhlx1jW4BNrWVVnUddKzlfMOlYzW2ltetaxoQvevRgmYNr5saehAou5aB6x1fk5dL210MP2ZM2Yw-ORwGO2GYk1FM1AK0KvD5X3Ab5jiVp5lSVrJWZfSavFqQiyGliL3ZRT_a-MsAM3cpmJKCWVIo-Nm-47wZsTvQ_bcX8GIPbHJ26KOdnE8H1yrJuISDC_Pu_wOrxZWE8PaPtPG7kYqrxpxdXpm2FR_0F3FlvhYvFo_l_288RpNcSdJh5yO6bLrg_zXmN4ffvjM</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Sneyd, J.R.</creator><creator>Langton, J.A.</creator><creator>Allan, L.G.</creator><creator>Peacock, J.E.</creator><creator>Rowbotham, D.J.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction</title><author>Sneyd, J.R. ; Langton, J.A. ; Allan, L.G. ; Peacock, J.E. ; Rowbotham, D.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-d59811b2a6a7dd1d0833b36c02e8a328c5514fcfea190532521f14e6d801cfc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>acute</topic><topic>acute pain</topic><topic>acute pain, novel techniques</topic><topic>Adenosine - administration & dosage</topic><topic>Adenosine - analogs & derivatives</topic><topic>Adenosine - therapeutic use</topic><topic>Adolescent</topic><topic>Adult</topic><topic>anaesthesia</topic><topic>anaesthesia, dental</topic><topic>analgesics non-opioid</topic><topic>analgesics non-opioid, diclofenac</topic><topic>Analgesics, Non-Narcotic - administration & dosage</topic><topic>Analgesics, Non-Narcotic - therapeutic use</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>dental</topic><topic>diclofenac</topic><topic>Diclofenac - therapeutic use</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molar, Third - surgery</topic><topic>novel techniques</topic><topic>pain</topic><topic>Pain Measurement - methods</topic><topic>pain, acute</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Pain, Postoperative - etiology</topic><topic>Purinergic P1 Receptor Agonists</topic><topic>Tooth Extraction - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sneyd, J.R.</creatorcontrib><creatorcontrib>Langton, J.A.</creatorcontrib><creatorcontrib>Allan, L.G.</creatorcontrib><creatorcontrib>Peacock, J.E.</creatorcontrib><creatorcontrib>Rowbotham, D.J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sneyd, J.R.</au><au>Langton, J.A.</au><au>Allan, L.G.</au><au>Peacock, J.E.</au><au>Rowbotham, D.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><stitle>Br J Anaesth</stitle><addtitle>Br J Anaesth</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>98</volume><issue>5</issue><spage>672</spage><epage>676</epage><pages>672-676</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>Adenosine is analgesic in humans, and the selective adenosine A1 receptor agonist GR79236X has significant anti-nociceptive activity in an animal pain model of inflammatory pain.
Seventy-nine patients with moderate pain after third molar extraction under general anaesthesia were randomized to receive a 15 min double-blind infusion containing either GR79236X 4 µg kg −1, GR79236X 10 µg kg −1, diclofenac 50 mg, or saline placebo. Rescue analgesia was promptly available to all patients.
Meaningful pain relief (mild or no pain) was attained by 9 (47%) patients in the placebo group, 12 (63%) patients in the GR79236 4 µg kg −1 group, 10 (48%) patients in the 10 µg kg −1 group, and 16 (80%) patients in the diclofenac 50 mg group. Neither dose of GR79236 produced a significant improvement over placebo, but diclofenac was superior to both placebo (P = 0.036) and GR79236 10 µg kg −1 (P = 0.034). Median times to rescue or additional analgesia were 62, 100, 60, and 363 min for patients receiving placebo, GR79236 4 µg kg −1, 10 µg kg −1, and diclofenac 50 mg, respectively (diclofenac significantly longer than placebo, P = 0.002 log-rank test). Pain control was poor in the placebo group and in both GR79236 groups, with between 79 and 86% of patients having good pain control (i.e. mild or no pain) for <20% of the time compared with only 30% of patients who received diclofenac.
We found no evidence of efficacy of GR79236 compared with placebo, but the active control diclofenac was effective. It is possible that a higher dose of GR79236 might have been effective or that i.v. administration of this drug does not achieve appropriate concentrations in the brain or peripheral nerves.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17416906</pmid><doi>10.1093/bja/aem075</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0912 |
| ispartof | British journal of anaesthesia : BJA, 2007-05, Vol.98 (5), p.672-676 |
| issn | 0007-0912 1471-6771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70424197 |
| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | acute acute pain acute pain, novel techniques Adenosine - administration & dosage Adenosine - analogs & derivatives Adenosine - therapeutic use Adolescent Adult anaesthesia anaesthesia, dental analgesics non-opioid analgesics non-opioid, diclofenac Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - therapeutic use Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences dental diclofenac Diclofenac - therapeutic use Dose-Response Relationship, Drug Double-Blind Method Female Humans Male Medical sciences Middle Aged Molar, Third - surgery novel techniques pain Pain Measurement - methods pain, acute Pain, Postoperative - drug therapy Pain, Postoperative - etiology Purinergic P1 Receptor Agonists Tooth Extraction - adverse effects |
| title | Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T18%3A02%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multicentre%20evaluation%20of%20the%20adenosine%20agonist%20GR79236X%20in%20patients%20with%20dental%20pain%20after%20third%20molar%20extraction&rft.jtitle=British%20journal%20of%20anaesthesia%20:%20BJA&rft.au=Sneyd,%20J.R.&rft.date=2007-05-01&rft.volume=98&rft.issue=5&rft.spage=672&rft.epage=676&rft.pages=672-676&rft.issn=0007-0912&rft.eissn=1471-6771&rft.coden=BJANAD&rft_id=info:doi/10.1093/bja/aem075&rft_dat=%3Cproquest_cross%3E1282528441%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=197762708&rft_id=info:pmid/17416906&rft_oup_id=10.1093/bja/aem075&rft_els_id=S0007091217348559&rfr_iscdi=true |