Solute-Inhibitor Interactions in the Plasmodial Surface Anion Channel Reveal Complexities in the Transport Process

Human red blood cells infected with the malaria parasite Plasmodium falciparum have markedly increased permeabilities to diverse organic and inorganic solutes. The plasmodial surface anion channel (PSAC), recently identified with electrophysiological methods, contributes to the uptake of many small...

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Veröffentlicht in:	Molecular pharmacology 2007-05, Vol.71 (5), p.1241-1250
Hauptverfasser:	Lisk, Godfrey, Scott, Seth, Solomon, Tsione, Pillai, Ajay D, Desai, Sanjay A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - metabolism Animals Biological Transport - drug effects Electrophysiology Erythrocytes - parasitology Furosemide - pharmacology Humans Ion Channels - antagonists & inhibitors Ion Channels - metabolism Isoleucine - metabolism Models, Biological Osmotic Pressure - drug effects Patch-Clamp Techniques Phenotype Phlorhizin - pharmacology Plasmodium falciparum Plasmodium falciparum - cytology Plasmodium falciparum - drug effects Quaternary Ammonium Compounds - metabolism Temperature
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