Conjugation of a Water-Soluble Gadolinium Endohedral Fulleride with an Antibody as a Magnetic Resonance Imaging Contrast Agent

Water-soluble gadofullerides exhibited high efficiency as magnetic resonance imaging (MRI) contrast agents. In this paper, we report the conjugation of the newly synthesized gadofulleride, Gd@C82O6(OH)16(NHCH2CH2COOH)8, with the antibody of green fluorescence protein (anti-GFP), as a model for “tumo...

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Veröffentlicht in:	Bioconjugate chemistry 2008-03, Vol.19 (3), p.651-655
Hauptverfasser:	Shu, Chun-Ying, Ma, Xin-Yong, Zhang, Jian-Fei, Corwin, Frank D, Sim, Jae Hyun, Zhang, Er-Yun, Dorn, Harry C, Gibson, Harry W, Fatouros, Panos P, Wang, Chun-Ru, Fang, Xiao-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - chemistry Biochemistry Biotin - chemistry Chemical Phenomena Chemistry, Physical Contrast Media - chemical synthesis Fluorescence Gadolinium - chemistry Green Fluorescent Proteins - immunology Immune system Indicators and Reagents Magnetic Resonance Imaging - methods Molecular Conformation Molecular Weight NMR Nuclear magnetic resonance Proteins Serum Albumin, Bovine - chemistry Solubility Spectrometry, Fluorescence Streptavidin - chemistry Water
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