Identification of novel molecular prognostic markers for paediatric T‐cell acute lymphoblastic leukaemia

Summary In the last four decades the survival of patients with newly diagnosed childhood T‐cell acute lymphoblastic leukaemia (T‐ALL) has improved dramatically. In sharp contrast, relapsed T‐ALL continues to confer a dismal prognosis. We sought to determine if gene expression profiling could uncover...

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Veröffentlicht in:	British journal of haematology 2007-05, Vol.137 (4), p.319-328
Hauptverfasser:	Gottardo, Nicholas G., Hoffmann, Katrin, Beesley, Alex H., Freitas, Joseph R., Firth, Martin J., Perera, Kanchana U., De Klerk, Nicolas H., Baker, David L., Kees, Ursula R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biological and medical sciences CASP8 and FADD-Like Apoptosis Regulating Protein - genetics Child Child, Preschool children Female gene expression Gene Expression Profiling Genetic Markers Hematologic and hematopoietic diseases Humans Leukemia-Lymphoma, Adult T-Cell - genetics Leukemia-Lymphoma, Adult T-Cell - mortality Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences microarray Multivariate Analysis Oligonucleotide Array Sequence Analysis Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Predictive Value of Tests Prognosis Proteins - genetics Receptor, Notch2 - genetics Reverse Transcriptase Polymerase Chain Reaction Survival Rate T‐cell acute lymphoblastic leukaemia
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