Fermentable metabolite of Zymomonas mobilis controls collagen reduction in photoaging skin by improving TGF-β/Smad signaling suppression

Solar ultraviolet (UV) irradiation causes damages on human skin and premature skin aging (photoaging). UV-induced reduction of type I collagen in dermis is widely considered primarily induction of wrinkled appearance of photoaging skin. Type I procollagen synthesis is reduced under UV irradiation by...

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Veröffentlicht in:	Archives of Dermatological Research 2008-04, Vol.300 (Suppl 1), p.57-64
Hauptverfasser:	Tanaka, Hiroshi, Yamaba, Hiroyuki, Kosugi, Nobuhiko, Mizutani, Hiroshi, Nakata, Satoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Collagen - biosynthesis Collagen Type I - analysis Collagen Type I - genetics Dermatology Down-Regulation Fermentation Gene Expression Regulation - drug effects Gene Expression Regulation - radiation effects Humans Male Medical sciences Medicine Medicine & Public Health Mice Mice, Hairless Original Paper Protein-Serine-Threonine Kinases - analysis Protein-Serine-Threonine Kinases - genetics Receptors, Transforming Growth Factor beta - analysis Receptors, Transforming Growth Factor beta - genetics RNA, Messenger - analysis Signal Transduction - drug effects Skin - radiation effects Skin Aging - drug effects Skin Aging - physiology Smad Proteins - physiology Transforming Growth Factor beta - physiology Ultraviolet Rays - adverse effects Zymomonas - metabolism Zymomonas mobilis
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