Determination of forsythiaside in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies
A simple high‐performance liquid chromatographic method was developed to study the pharmacokinetics of forsythiaside in rat plasma after intravenous administration. Hesperidin was used as the internal standard. The drugs were separated on a reversed‐phase C18 column and detected at 332 nm. Good line...
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| Veröffentlicht in: | Biomedical chromatography 2008-04, Vol.22 (4), p.361-366 |
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| creator | Li, Yun-Xia Jiang, Xue-Hua Liang, Hu-Yi Li, Xue |
| description | A simple high‐performance liquid chromatographic method was developed to study the pharmacokinetics of forsythiaside in rat plasma after intravenous administration. Hesperidin was used as the internal standard. The drugs were separated on a reversed‐phase C18 column and detected at 332 nm. Good linearity was achieved in the range of 0.067–26.667 µg/mL. The intra‐ and inter‐assay variation coefficients for this analysis were no more than 10.94 and 14.56%, respectively. The average recovery for forsythiaside was 87.42% from plasma. The analytical sensitivity and accuracy of this assay were adequate for characterization of the pharmacokinetics of intravenous administration of forsythiaside to rats and the assay has been successfully applied to provide pharmacokinetic data. The mean t1/2Z was 20.36, 19.40 and 23.62 min for 2, 5 and 20 mg/kg for forsythiaside after i.v. administration, respectively. The AUC0−t increased linearly from 40.64 to 624.14 µg min/mL after administration of the three doses. Copyright © 2007 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/bmc.940 |
| format | Article |
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Hesperidin was used as the internal standard. The drugs were separated on a reversed‐phase C18 column and detected at 332 nm. Good linearity was achieved in the range of 0.067–26.667 µg/mL. The intra‐ and inter‐assay variation coefficients for this analysis were no more than 10.94 and 14.56%, respectively. The average recovery for forsythiaside was 87.42% from plasma. The analytical sensitivity and accuracy of this assay were adequate for characterization of the pharmacokinetics of intravenous administration of forsythiaside to rats and the assay has been successfully applied to provide pharmacokinetic data. The mean t1/2Z was 20.36, 19.40 and 23.62 min for 2, 5 and 20 mg/kg for forsythiaside after i.v. administration, respectively. The AUC0−t increased linearly from 40.64 to 624.14 µg min/mL after administration of the three doses. Copyright © 2007 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0269-3879</identifier><identifier>EISSN: 1099-0801</identifier><identifier>DOI: 10.1002/bmc.940</identifier><identifier>PMID: 18059053</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Chromatography, High Pressure Liquid - methods ; determination ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - pharmacokinetics ; forsythiaside ; Glycosides - blood ; Glycosides - chemistry ; Glycosides - pharmacokinetics ; HPLC ; Male ; Molecular Structure ; pharmacokinetics ; rat plasma ; Rats ; Reproducibility of Results</subject><ispartof>Biomedical chromatography, 2008-04, Vol.22 (4), p.361-366</ispartof><rights>Copyright © 2007 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-921aee3e892ba18c32070317dfa957b3b513a48fe712e8527a608a212e053a893</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbmc.940$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbmc.940$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18059053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yun-Xia</creatorcontrib><creatorcontrib>Jiang, Xue-Hua</creatorcontrib><creatorcontrib>Liang, Hu-Yi</creatorcontrib><creatorcontrib>Li, Xue</creatorcontrib><title>Determination of forsythiaside in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies</title><title>Biomedical chromatography</title><addtitle>Biomed. Chromatogr</addtitle><description>A simple high‐performance liquid chromatographic method was developed to study the pharmacokinetics of forsythiaside in rat plasma after intravenous administration. Hesperidin was used as the internal standard. The drugs were separated on a reversed‐phase C18 column and detected at 332 nm. Good linearity was achieved in the range of 0.067–26.667 µg/mL. The intra‐ and inter‐assay variation coefficients for this analysis were no more than 10.94 and 14.56%, respectively. The average recovery for forsythiaside was 87.42% from plasma. The analytical sensitivity and accuracy of this assay were adequate for characterization of the pharmacokinetics of intravenous administration of forsythiaside to rats and the assay has been successfully applied to provide pharmacokinetic data. The mean t1/2Z was 20.36, 19.40 and 23.62 min for 2, 5 and 20 mg/kg for forsythiaside after i.v. administration, respectively. The AUC0−t increased linearly from 40.64 to 624.14 µg min/mL after administration of the three doses. Copyright © 2007 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>determination</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - pharmacokinetics</subject><subject>forsythiaside</subject><subject>Glycosides - blood</subject><subject>Glycosides - chemistry</subject><subject>Glycosides - pharmacokinetics</subject><subject>HPLC</subject><subject>Male</subject><subject>Molecular Structure</subject><subject>pharmacokinetics</subject><subject>rat plasma</subject><subject>Rats</subject><subject>Reproducibility of Results</subject><issn>0269-3879</issn><issn>1099-0801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFu1DAQQC0EoktB_AHyCQ4oxY43a_tIt7SLaOEC4mhNnEljmsSp7QjyAfx3jbKCEydrpDdP40fIS87OOGPlu3qwZ3rLHpENZ1oXTDH-mGxYudOFUFKfkGcx_mCM6V0pn5ITrlilWSU25PcFJgyDGyE5P1Lf0taHuKTOQXQNUjfSAIlOPcQBaL3Qzt12xYQhYwOMFmnv7mfXUNsFP0DytwGmbqEwNtSlSGGaemdXefJ06iCvWX_nRkzO0pjmxmF8Tp600Ed8cXxPybfLD1_3h-L6y9XH_fvrwopKsEKXHBAFKl3WwJUVJZNMcNm0oCtZi7riAraqRclLVFUpYccUlHnIfwWlxSl5vXqn4O9njMkMLlrsexjRz9FItuU7obYZfLOCNvgYA7ZmCm6AsBjOzJ_iJhc3uXgmXx2Vcz1g8487Js7A2xX46Xpc_ucx5zf7VVestIsJf_2lIdyZnRSyMt8_X5lPh8NNPrMyF-IBUYWa7A</recordid><startdate>200804</startdate><enddate>200804</enddate><creator>Li, Yun-Xia</creator><creator>Jiang, Xue-Hua</creator><creator>Liang, Hu-Yi</creator><creator>Li, Xue</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200804</creationdate><title>Determination of forsythiaside in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies</title><author>Li, Yun-Xia ; Jiang, Xue-Hua ; Liang, Hu-Yi ; Li, Xue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-921aee3e892ba18c32070317dfa957b3b513a48fe712e8527a608a212e053a893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>determination</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - pharmacokinetics</topic><topic>forsythiaside</topic><topic>Glycosides - blood</topic><topic>Glycosides - chemistry</topic><topic>Glycosides - pharmacokinetics</topic><topic>HPLC</topic><topic>Male</topic><topic>Molecular Structure</topic><topic>pharmacokinetics</topic><topic>rat plasma</topic><topic>Rats</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yun-Xia</creatorcontrib><creatorcontrib>Jiang, Xue-Hua</creatorcontrib><creatorcontrib>Liang, Hu-Yi</creatorcontrib><creatorcontrib>Li, Xue</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedical chromatography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yun-Xia</au><au>Jiang, Xue-Hua</au><au>Liang, Hu-Yi</au><au>Li, Xue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of forsythiaside in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies</atitle><jtitle>Biomedical chromatography</jtitle><addtitle>Biomed. Chromatogr</addtitle><date>2008-04</date><risdate>2008</risdate><volume>22</volume><issue>4</issue><spage>361</spage><epage>366</epage><pages>361-366</pages><issn>0269-3879</issn><eissn>1099-0801</eissn><abstract>A simple high‐performance liquid chromatographic method was developed to study the pharmacokinetics of forsythiaside in rat plasma after intravenous administration. Hesperidin was used as the internal standard. The drugs were separated on a reversed‐phase C18 column and detected at 332 nm. Good linearity was achieved in the range of 0.067–26.667 µg/mL. The intra‐ and inter‐assay variation coefficients for this analysis were no more than 10.94 and 14.56%, respectively. The average recovery for forsythiaside was 87.42% from plasma. The analytical sensitivity and accuracy of this assay were adequate for characterization of the pharmacokinetics of intravenous administration of forsythiaside to rats and the assay has been successfully applied to provide pharmacokinetic data. The mean t1/2Z was 20.36, 19.40 and 23.62 min for 2, 5 and 20 mg/kg for forsythiaside after i.v. administration, respectively. The AUC0−t increased linearly from 40.64 to 624.14 µg min/mL after administration of the three doses. Copyright © 2007 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>18059053</pmid><doi>10.1002/bmc.940</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Chromatography, High Pressure Liquid - methods determination Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacokinetics forsythiaside Glycosides - blood Glycosides - chemistry Glycosides - pharmacokinetics HPLC Male Molecular Structure pharmacokinetics rat plasma Rats Reproducibility of Results |
| title | Determination of forsythiaside in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies |
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