The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro
Lymphoid depletion of various lymphoid organs is one of the major lesions in pigs suffering from postweaning multisystemic wasting syndrome (PMWS). The co-existence of porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) in PMWS-affected pigs along with th...
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| creator | Chang, Hui-Wen Jeng, Chian-Ren Lin, Chun-Ming Liu, Jiuan Judy Chang, Chih-Cheng Tsai, Yi-Chieh Chia, Mi-Yuan Pang, Victor Fei |
| description | Lymphoid depletion of various lymphoid organs is one of the major lesions in pigs suffering from postweaning multisystemic wasting syndrome (PMWS). The co-existence of porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) in PMWS-affected pigs along with the more severe and wider range of lymphocyte depletion of lymphoid organs in PCV2 and PRRSV dually-inoculated pigs imply that PCV2 and PRRSV may interact in the pathogenesis of PMWS. The mechanism for the development of lymphoid depletion in PMWS-affected pigs remains controversial. The objective of the present study was to evaluate and compare the effects of inoculation of both viruses, singularly or in combination, on swine splenic macrophages (SMs) and co-cultured splenic (SLs) and peripheral blood (PBLs) lymphocytes
in vitro. A significant reduction in the survival rate and increase in the apoptotic rate of the co-cultured SLs and PBLs and concurrent increase in the expression levels of Fas ligand (FasL) in SMs and Fas in co-cultured SLs and PBLs were demonstrated in PRRSV alone- and PCV2 and PRRSV dually-inoculated groups with the latter more prominent. The increased FasL was proven capable of inducing Fas/FasL-mediated apoptosis in co-cultured FasL-sensitive Jurkat T cells. The de novo expression and production of FasL in PCV2 and PRRSV dually-inoculated SMs and concurrently increased surface expression of Fas in co-cultured lymphocytes may contribute, at least partially, to lymphoid depletion in PMWS-affected pigs with PCV2 and PRRSV dual infection. |
| doi_str_mv | 10.1016/j.vetmic.2007.01.013 |
| format | Article |
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in vitro. A significant reduction in the survival rate and increase in the apoptotic rate of the co-cultured SLs and PBLs and concurrent increase in the expression levels of Fas ligand (FasL) in SMs and Fas in co-cultured SLs and PBLs were demonstrated in PRRSV alone- and PCV2 and PRRSV dually-inoculated groups with the latter more prominent. The increased FasL was proven capable of inducing Fas/FasL-mediated apoptosis in co-cultured FasL-sensitive Jurkat T cells. The de novo expression and production of FasL in PCV2 and PRRSV dually-inoculated SMs and concurrently increased surface expression of Fas in co-cultured lymphocytes may contribute, at least partially, to lymphoid depletion in PMWS-affected pigs with PCV2 and PRRSV dual infection.</description><identifier>ISSN: 0378-1135</identifier><identifier>EISSN: 1873-2542</identifier><identifier>DOI: 10.1016/j.vetmic.2007.01.013</identifier><identifier>PMID: 17321702</identifier><identifier>CODEN: VMICDQ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Apoptosis ; Apoptosis - physiology ; Biological and medical sciences ; cell culture ; Circovirus - metabolism ; complications ; Fas Ligand Protein - genetics ; Fas Ligand Protein - metabolism ; fas Receptor - genetics ; fas Receptor - metabolism ; Fas/FasL ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Humans ; immune response ; immunologic deficiency syndromes ; immunosuppression (physiological) ; Jurkat Cells ; lymphocytes ; Lymphocytes - metabolism ; Lymphocytes - virology ; macrophages ; Macrophages - metabolism ; Macrophages - virology ; Male ; Microbiology ; Miscellaneous ; mixed infection ; pathogenesis ; Porcine circovirus ; Porcine circovirus type 2 (PCV2) ; porcine reproductive and respiratory syndrome ; Porcine reproductive and respiratory syndrome virus ; Porcine reproductive and respiratory syndrome virus (PRRSV) ; Porcine respiratory and reproductive syndrome virus ; Porcine respiratory and reproductive syndrome virus - metabolism ; postweaning multisystemic wasting syndrome ; Postweaning multisystemic wasting syndrome (PMWS) ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; spleen ; Spleen - cytology ; Swine ; Virology</subject><ispartof>Veterinary microbiology, 2007-05, Vol.122 (1), p.72-82</ispartof><rights>2007 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-f5e1b0c880555230e85ae60dcae69edc8ce83b0e09728cdcce1e846856ef5c6b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.vetmic.2007.01.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18716804$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17321702$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Hui-Wen</creatorcontrib><creatorcontrib>Jeng, Chian-Ren</creatorcontrib><creatorcontrib>Lin, Chun-Ming</creatorcontrib><creatorcontrib>Liu, Jiuan Judy</creatorcontrib><creatorcontrib>Chang, Chih-Cheng</creatorcontrib><creatorcontrib>Tsai, Yi-Chieh</creatorcontrib><creatorcontrib>Chia, Mi-Yuan</creatorcontrib><creatorcontrib>Pang, Victor Fei</creatorcontrib><title>The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro</title><title>Veterinary microbiology</title><addtitle>Vet Microbiol</addtitle><description>Lymphoid depletion of various lymphoid organs is one of the major lesions in pigs suffering from postweaning multisystemic wasting syndrome (PMWS). The co-existence of porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) in PMWS-affected pigs along with the more severe and wider range of lymphocyte depletion of lymphoid organs in PCV2 and PRRSV dually-inoculated pigs imply that PCV2 and PRRSV may interact in the pathogenesis of PMWS. The mechanism for the development of lymphoid depletion in PMWS-affected pigs remains controversial. The objective of the present study was to evaluate and compare the effects of inoculation of both viruses, singularly or in combination, on swine splenic macrophages (SMs) and co-cultured splenic (SLs) and peripheral blood (PBLs) lymphocytes
in vitro. A significant reduction in the survival rate and increase in the apoptotic rate of the co-cultured SLs and PBLs and concurrent increase in the expression levels of Fas ligand (FasL) in SMs and Fas in co-cultured SLs and PBLs were demonstrated in PRRSV alone- and PCV2 and PRRSV dually-inoculated groups with the latter more prominent. The increased FasL was proven capable of inducing Fas/FasL-mediated apoptosis in co-cultured FasL-sensitive Jurkat T cells. The de novo expression and production of FasL in PCV2 and PRRSV dually-inoculated SMs and concurrently increased surface expression of Fas in co-cultured lymphocytes may contribute, at least partially, to lymphoid depletion in PMWS-affected pigs with PCV2 and PRRSV dual infection.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - physiology</subject><subject>Biological and medical sciences</subject><subject>cell culture</subject><subject>Circovirus - metabolism</subject><subject>complications</subject><subject>Fas Ligand Protein - genetics</subject><subject>Fas Ligand Protein - metabolism</subject><subject>fas Receptor - genetics</subject><subject>fas Receptor - metabolism</subject><subject>Fas/FasL</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>immune response</subject><subject>immunologic deficiency syndromes</subject><subject>immunosuppression (physiological)</subject><subject>Jurkat Cells</subject><subject>lymphocytes</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - virology</subject><subject>macrophages</subject><subject>Macrophages - metabolism</subject><subject>Macrophages - virology</subject><subject>Male</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>mixed infection</subject><subject>pathogenesis</subject><subject>Porcine circovirus</subject><subject>Porcine circovirus type 2 (PCV2)</subject><subject>porcine reproductive and respiratory syndrome</subject><subject>Porcine reproductive and respiratory syndrome virus</subject><subject>Porcine reproductive and respiratory syndrome virus (PRRSV)</subject><subject>Porcine respiratory and reproductive syndrome virus</subject><subject>Porcine respiratory and reproductive syndrome virus - metabolism</subject><subject>postweaning multisystemic wasting syndrome</subject><subject>Postweaning multisystemic wasting syndrome (PMWS)</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>spleen</subject><subject>Spleen - cytology</subject><subject>Swine</subject><subject>Virology</subject><issn>0378-1135</issn><issn>1873-2542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAQxyMEotvCGyDwBW7Zjp048V6QUEUL0kocaM-WdzKhXiVxsJ1IeS8eEC9Z0RtI4w95fv_58GTZGw5bDry6Pm5nir3FrQCot8CTFc-yDVd1kQtZiufZBopa5ZwX8iK7DOEIAOWugpfZBa8LwWsQm-zX_SMxO8yum6mnITLXslsTrtPap_dI3mC0bkh3NjqPdiCG1qObrZ8Ci8tITDAzNH-9nkbvmimpZvrj8BRG6010fmFhGRrvemKrHF1uB4dTZ045chOCQ2siNaxb-vHR4RJTjNGN0QUbTjXMNnr3KnvRmi7Q6_N5lT3cfr6_-ZLvv919vfm0z7EsZcxbSfwAqBRIKUUBpKShChpM-44aVEiqOADBrhYKG0TipMpKyYpaidWhuMo-rHFTRz8nClH3NiB1nRnITUHXUHKpqvq_oICiAqF4AssVRO9C8NTq0dve-EVz0Kex6qNex6pPY9XAkxVJ9vYcfzr01DyJznNMwPszYAKarvVmQBueOFXzSkGZuHcr1xqnzQ-fmIfvIqVIyVLjuxPxcSUofexsyeuAlgakxnrCqBtn_13rb0KL0bY</recordid><startdate>20070516</startdate><enddate>20070516</enddate><creator>Chang, Hui-Wen</creator><creator>Jeng, Chian-Ren</creator><creator>Lin, Chun-Ming</creator><creator>Liu, Jiuan Judy</creator><creator>Chang, Chih-Cheng</creator><creator>Tsai, Yi-Chieh</creator><creator>Chia, Mi-Yuan</creator><creator>Pang, Victor Fei</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070516</creationdate><title>The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro</title><author>Chang, Hui-Wen ; Jeng, Chian-Ren ; Lin, Chun-Ming ; Liu, Jiuan Judy ; Chang, Chih-Cheng ; Tsai, Yi-Chieh ; Chia, Mi-Yuan ; Pang, Victor Fei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-f5e1b0c880555230e85ae60dcae69edc8ce83b0e09728cdcce1e846856ef5c6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - physiology</topic><topic>Biological and medical sciences</topic><topic>cell culture</topic><topic>Circovirus - metabolism</topic><topic>complications</topic><topic>Fas Ligand Protein - genetics</topic><topic>Fas Ligand Protein - metabolism</topic><topic>fas Receptor - genetics</topic><topic>fas Receptor - metabolism</topic><topic>Fas/FasL</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>immune response</topic><topic>immunologic deficiency syndromes</topic><topic>immunosuppression (physiological)</topic><topic>Jurkat Cells</topic><topic>lymphocytes</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphocytes - virology</topic><topic>macrophages</topic><topic>Macrophages - metabolism</topic><topic>Macrophages - virology</topic><topic>Male</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>mixed infection</topic><topic>pathogenesis</topic><topic>Porcine circovirus</topic><topic>Porcine circovirus type 2 (PCV2)</topic><topic>porcine reproductive and respiratory syndrome</topic><topic>Porcine reproductive and respiratory syndrome virus</topic><topic>Porcine reproductive and respiratory syndrome virus (PRRSV)</topic><topic>Porcine respiratory and reproductive syndrome virus</topic><topic>Porcine respiratory and reproductive syndrome virus - metabolism</topic><topic>postweaning multisystemic wasting syndrome</topic><topic>Postweaning multisystemic wasting syndrome (PMWS)</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>spleen</topic><topic>Spleen - cytology</topic><topic>Swine</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Hui-Wen</creatorcontrib><creatorcontrib>Jeng, Chian-Ren</creatorcontrib><creatorcontrib>Lin, Chun-Ming</creatorcontrib><creatorcontrib>Liu, Jiuan Judy</creatorcontrib><creatorcontrib>Chang, Chih-Cheng</creatorcontrib><creatorcontrib>Tsai, Yi-Chieh</creatorcontrib><creatorcontrib>Chia, Mi-Yuan</creatorcontrib><creatorcontrib>Pang, Victor Fei</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Hui-Wen</au><au>Jeng, Chian-Ren</au><au>Lin, Chun-Ming</au><au>Liu, Jiuan Judy</au><au>Chang, Chih-Cheng</au><au>Tsai, Yi-Chieh</au><au>Chia, Mi-Yuan</au><au>Pang, Victor Fei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro</atitle><jtitle>Veterinary microbiology</jtitle><addtitle>Vet Microbiol</addtitle><date>2007-05-16</date><risdate>2007</risdate><volume>122</volume><issue>1</issue><spage>72</spage><epage>82</epage><pages>72-82</pages><issn>0378-1135</issn><eissn>1873-2542</eissn><coden>VMICDQ</coden><abstract>Lymphoid depletion of various lymphoid organs is one of the major lesions in pigs suffering from postweaning multisystemic wasting syndrome (PMWS). The co-existence of porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) in PMWS-affected pigs along with the more severe and wider range of lymphocyte depletion of lymphoid organs in PCV2 and PRRSV dually-inoculated pigs imply that PCV2 and PRRSV may interact in the pathogenesis of PMWS. The mechanism for the development of lymphoid depletion in PMWS-affected pigs remains controversial. The objective of the present study was to evaluate and compare the effects of inoculation of both viruses, singularly or in combination, on swine splenic macrophages (SMs) and co-cultured splenic (SLs) and peripheral blood (PBLs) lymphocytes
in vitro. A significant reduction in the survival rate and increase in the apoptotic rate of the co-cultured SLs and PBLs and concurrent increase in the expression levels of Fas ligand (FasL) in SMs and Fas in co-cultured SLs and PBLs were demonstrated in PRRSV alone- and PCV2 and PRRSV dually-inoculated groups with the latter more prominent. The increased FasL was proven capable of inducing Fas/FasL-mediated apoptosis in co-cultured FasL-sensitive Jurkat T cells. The de novo expression and production of FasL in PCV2 and PRRSV dually-inoculated SMs and concurrently increased surface expression of Fas in co-cultured lymphocytes may contribute, at least partially, to lymphoid depletion in PMWS-affected pigs with PCV2 and PRRSV dual infection.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17321702</pmid><doi>10.1016/j.vetmic.2007.01.013</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Apoptosis Apoptosis - physiology Biological and medical sciences cell culture Circovirus - metabolism complications Fas Ligand Protein - genetics Fas Ligand Protein - metabolism fas Receptor - genetics fas Receptor - metabolism Fas/FasL Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation Humans immune response immunologic deficiency syndromes immunosuppression (physiological) Jurkat Cells lymphocytes Lymphocytes - metabolism Lymphocytes - virology macrophages Macrophages - metabolism Macrophages - virology Male Microbiology Miscellaneous mixed infection pathogenesis Porcine circovirus Porcine circovirus type 2 (PCV2) porcine reproductive and respiratory syndrome Porcine reproductive and respiratory syndrome virus Porcine reproductive and respiratory syndrome virus (PRRSV) Porcine respiratory and reproductive syndrome virus Porcine respiratory and reproductive syndrome virus - metabolism postweaning multisystemic wasting syndrome Postweaning multisystemic wasting syndrome (PMWS) RNA, Messenger - genetics RNA, Messenger - metabolism spleen Spleen - cytology Swine Virology |
| title | The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro |
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