The unique regulation of Aedes aegypti larval cell ferritin by iron
Mosquitoes must blood feed in order to complete their life cycle. The blood meal provides a high level of iron that is required for egg development. We are interested in developing control strategies that interfere with this process. We report the temporal effects of iron exposure on iron metabolism...
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| Veröffentlicht in: | Insect biochemistry and molecular biology 2007-05, Vol.37 (5), p.418-429 |
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| container_title | Insect biochemistry and molecular biology |
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| creator | Geiser, Dawn L. Mayo, Jonathan J. Winzerling, Joy J. |
| description | Mosquitoes must blood feed in order to complete their life cycle. The blood meal provides a high level of iron that is required for egg development. We are interested in developing control strategies that interfere with this process. We report the temporal effects of iron exposure on iron metabolism of
Aedes aegypti larval cells. These cells take up iron in linear relationship to exposure time and distribute the iron primarily to the membranes. Iron uptake increases cytoplasmic, membrane and secreted ferritin. Membrane ferritin is abundant in cells treated with iron, increases in cells in the absence of iron exposure and is associated with the secretory pathway. Our data suggest that in contrast to mammals, mosquitoes control intracellular iron levels by producing membrane ferritin in anticipation of an iron load such as that provided by a blood meal and support the hypothesis that secreted ferritin is a primary iron storage protein for these animals. |
| doi_str_mv | 10.1016/j.ibmb.2007.01.003 |
| format | Article |
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Aedes aegypti larval cells. These cells take up iron in linear relationship to exposure time and distribute the iron primarily to the membranes. Iron uptake increases cytoplasmic, membrane and secreted ferritin. Membrane ferritin is abundant in cells treated with iron, increases in cells in the absence of iron exposure and is associated with the secretory pathway. Our data suggest that in contrast to mammals, mosquitoes control intracellular iron levels by producing membrane ferritin in anticipation of an iron load such as that provided by a blood meal and support the hypothesis that secreted ferritin is a primary iron storage protein for these animals.</description><identifier>ISSN: 0965-1748</identifier><identifier>EISSN: 1879-0240</identifier><identifier>DOI: 10.1016/j.ibmb.2007.01.003</identifier><identifier>PMID: 17456437</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aedes - drug effects ; Aedes - growth & development ; Aedes - metabolism ; Aedes aegypti ; Aedes aegypti mosquito ; Animals ; Apoferritins - genetics ; Apoferritins - metabolism ; cell lines ; Cell Membrane - metabolism ; cell membranes ; Cells, Cultured ; Cytoplasm - metabolism ; Ferritin ; ferritin heavy chain ; ferritin light chain ; ferritin secretion ; Ferritins - genetics ; Ferritins - metabolism ; Gene Expression Regulation - drug effects ; hematophagous insects ; Insect Proteins - genetics ; Insect Proteins - metabolism ; iron ; Iron - metabolism ; Iron - pharmacology ; Iron regulatory protein 1 ; iron storage protein ; iron uptake ; Larva - drug effects ; Larva - metabolism ; messenger RNA ; physiological regulation ; protein secretion ; protein subunits ; Secretion ; storage proteins ; temporal variation ; uptake mechanisms</subject><ispartof>Insect biochemistry and molecular biology, 2007-05, Vol.37 (5), p.418-429</ispartof><rights>2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-f6b4e443a26fbb6bb4e34bb45c6ec814008563c4c2fa1f1ece33c698d40e36ca3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ibmb.2007.01.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17456437$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Geiser, Dawn L.</creatorcontrib><creatorcontrib>Mayo, Jonathan J.</creatorcontrib><creatorcontrib>Winzerling, Joy J.</creatorcontrib><title>The unique regulation of Aedes aegypti larval cell ferritin by iron</title><title>Insect biochemistry and molecular biology</title><addtitle>Insect Biochem Mol Biol</addtitle><description>Mosquitoes must blood feed in order to complete their life cycle. The blood meal provides a high level of iron that is required for egg development. We are interested in developing control strategies that interfere with this process. We report the temporal effects of iron exposure on iron metabolism of
Aedes aegypti larval cells. These cells take up iron in linear relationship to exposure time and distribute the iron primarily to the membranes. Iron uptake increases cytoplasmic, membrane and secreted ferritin. Membrane ferritin is abundant in cells treated with iron, increases in cells in the absence of iron exposure and is associated with the secretory pathway. Our data suggest that in contrast to mammals, mosquitoes control intracellular iron levels by producing membrane ferritin in anticipation of an iron load such as that provided by a blood meal and support the hypothesis that secreted ferritin is a primary iron storage protein for these animals.</description><subject>Aedes - drug effects</subject><subject>Aedes - growth & development</subject><subject>Aedes - metabolism</subject><subject>Aedes aegypti</subject><subject>Aedes aegypti mosquito</subject><subject>Animals</subject><subject>Apoferritins - genetics</subject><subject>Apoferritins - metabolism</subject><subject>cell lines</subject><subject>Cell Membrane - metabolism</subject><subject>cell membranes</subject><subject>Cells, Cultured</subject><subject>Cytoplasm - metabolism</subject><subject>Ferritin</subject><subject>ferritin heavy chain</subject><subject>ferritin light chain</subject><subject>ferritin secretion</subject><subject>Ferritins - genetics</subject><subject>Ferritins - metabolism</subject><subject>Gene Expression Regulation - drug effects</subject><subject>hematophagous insects</subject><subject>Insect Proteins - genetics</subject><subject>Insect Proteins - metabolism</subject><subject>iron</subject><subject>Iron - metabolism</subject><subject>Iron - pharmacology</subject><subject>Iron regulatory protein 1</subject><subject>iron storage protein</subject><subject>iron uptake</subject><subject>Larva - drug effects</subject><subject>Larva - metabolism</subject><subject>messenger RNA</subject><subject>physiological regulation</subject><subject>protein secretion</subject><subject>protein subunits</subject><subject>Secretion</subject><subject>storage proteins</subject><subject>temporal variation</subject><subject>uptake mechanisms</subject><issn>0965-1748</issn><issn>1879-0240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78AQ-ak7fWSZOmLXiRxS8QPKjnkKaTNUu3XZN2Yf-9KbvgTS8TJjzz8vIQcskgZcDk7TJ19apOM4AiBZYC8AMyY2VRJZAJOCQzqGSesEKUJ-Q0hCUACJEXx-Qk_uVS8GJG5h9fSMfOfY9IPS7GVg-u72hv6T02GKjGxXY9ONpqv9EtNdi21KL3bnAdrbfU-b47J0dWtwEv9u8Z-Xx8-Jg_J69vTy_z-9fECKiGxMpaoBBcZ9LWtazjxkWcuZFoSiYAylxyI0xmNbMMDXJuZFU2ApBLo_kZudnlrn0f-4ZBrVyYGukO-zGoAgTLi7z8F2SVjLmiiGC2A43vQ_Bo1dq7lfZbxUBNjtVSTY7V5FgBU9FxPLrap4_1Cpvfk73UCFzvAKt7pRfeBfX5ngHjMSQyYip4tyMw6to49CoYh53Bxnk0g2p691eDH-U2lh4</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Geiser, Dawn L.</creator><creator>Mayo, Jonathan J.</creator><creator>Winzerling, Joy J.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>The unique regulation of Aedes aegypti larval cell ferritin by iron</title><author>Geiser, Dawn L. ; Mayo, Jonathan J. ; Winzerling, Joy J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-f6b4e443a26fbb6bb4e34bb45c6ec814008563c4c2fa1f1ece33c698d40e36ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aedes - drug effects</topic><topic>Aedes - growth & development</topic><topic>Aedes - metabolism</topic><topic>Aedes aegypti</topic><topic>Aedes aegypti mosquito</topic><topic>Animals</topic><topic>Apoferritins - genetics</topic><topic>Apoferritins - metabolism</topic><topic>cell lines</topic><topic>Cell Membrane - metabolism</topic><topic>cell membranes</topic><topic>Cells, Cultured</topic><topic>Cytoplasm - metabolism</topic><topic>Ferritin</topic><topic>ferritin heavy chain</topic><topic>ferritin light chain</topic><topic>ferritin secretion</topic><topic>Ferritins - genetics</topic><topic>Ferritins - metabolism</topic><topic>Gene Expression Regulation - drug effects</topic><topic>hematophagous insects</topic><topic>Insect Proteins - genetics</topic><topic>Insect Proteins - metabolism</topic><topic>iron</topic><topic>Iron - metabolism</topic><topic>Iron - pharmacology</topic><topic>Iron regulatory protein 1</topic><topic>iron storage protein</topic><topic>iron uptake</topic><topic>Larva - drug effects</topic><topic>Larva - metabolism</topic><topic>messenger RNA</topic><topic>physiological regulation</topic><topic>protein secretion</topic><topic>protein subunits</topic><topic>Secretion</topic><topic>storage proteins</topic><topic>temporal variation</topic><topic>uptake mechanisms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geiser, Dawn L.</creatorcontrib><creatorcontrib>Mayo, Jonathan J.</creatorcontrib><creatorcontrib>Winzerling, Joy J.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>MEDLINE - Academic</collection><jtitle>Insect biochemistry and molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geiser, Dawn L.</au><au>Mayo, Jonathan J.</au><au>Winzerling, Joy J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The unique regulation of Aedes aegypti larval cell ferritin by iron</atitle><jtitle>Insect biochemistry and molecular biology</jtitle><addtitle>Insect Biochem Mol Biol</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>37</volume><issue>5</issue><spage>418</spage><epage>429</epage><pages>418-429</pages><issn>0965-1748</issn><eissn>1879-0240</eissn><abstract>Mosquitoes must blood feed in order to complete their life cycle. The blood meal provides a high level of iron that is required for egg development. We are interested in developing control strategies that interfere with this process. We report the temporal effects of iron exposure on iron metabolism of
Aedes aegypti larval cells. These cells take up iron in linear relationship to exposure time and distribute the iron primarily to the membranes. Iron uptake increases cytoplasmic, membrane and secreted ferritin. Membrane ferritin is abundant in cells treated with iron, increases in cells in the absence of iron exposure and is associated with the secretory pathway. Our data suggest that in contrast to mammals, mosquitoes control intracellular iron levels by producing membrane ferritin in anticipation of an iron load such as that provided by a blood meal and support the hypothesis that secreted ferritin is a primary iron storage protein for these animals.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17456437</pmid><doi>10.1016/j.ibmb.2007.01.003</doi><tpages>12</tpages></addata></record> |
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| subjects | Aedes - drug effects Aedes - growth & development Aedes - metabolism Aedes aegypti Aedes aegypti mosquito Animals Apoferritins - genetics Apoferritins - metabolism cell lines Cell Membrane - metabolism cell membranes Cells, Cultured Cytoplasm - metabolism Ferritin ferritin heavy chain ferritin light chain ferritin secretion Ferritins - genetics Ferritins - metabolism Gene Expression Regulation - drug effects hematophagous insects Insect Proteins - genetics Insect Proteins - metabolism iron Iron - metabolism Iron - pharmacology Iron regulatory protein 1 iron storage protein iron uptake Larva - drug effects Larva - metabolism messenger RNA physiological regulation protein secretion protein subunits Secretion storage proteins temporal variation uptake mechanisms |
| title | The unique regulation of Aedes aegypti larval cell ferritin by iron |
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