Hyaluronidases in Loxosceles intermedia (Brown spider) venom are endo- β-N-acetyl- d-hexosaminidases hydrolases

In studying Loxosceles venom, we detected degradation of purified hyaluronic acid (HA) and hydrolysis of purified chondroitin sulphate (CS) while neither dermatan sulphate, heparin or heparan sulphate were affected. In addition, with HA-degrading kinetic assays, we show that a hydrolase enzyme was i...

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Veröffentlicht in:	Toxicon (Oxford) 2007-05, Vol.49 (6), p.758-768
Hauptverfasser:	da Silveira, Rafael Bertoni, Chaim, Olga Meiri, Mangili, Oldemir Carlos, Gremski, Waldemiro, Dietrich, Carl Peter, Nader, Helena B., Veiga, Silvio Sanches
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal poisons toxicology. Antivenoms Animals Araneae Biological and medical sciences Brown spider Electrophoresis, Agar Gel Electrophoresis, Polyacrylamide Gel Hyaluronoglucosaminidase - chemistry Hydrogen-Ion Concentration Loxosceles Loxosceles intermedia Loxosceles intermedia venom and hyaluronidases Medical sciences Phosphoric Diester Hydrolases - chemistry Rabbits Serine Endopeptidases - chemistry Spectrometry, Fluorescence Spider Venoms - chemistry Spiders Structure-Activity Relationship Toxicology
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