Vitamin B-12 Deficiency Is Prevalent in 35- to 64-Year-Old Chinese Adults
Low vitamin B-12 status alone, or in combination with low folate status, is related to neural tube defects (NTD) and hyperhomocysteinemia, a risk factor for atherosclerotic disease, but little is known about vitamin B-12 status in Chinese adults. In a cross-sectional study, we measured plasma vitami...
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| Veröffentlicht in: | The Journal of nutrition 2007-05, Vol.137 (5), p.1278-1285 |
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| creator | Hao, Ling Ma, Jing Zhu, Jianghui Stampfer, Meir J Tian, Yihua Willett, Walter C Li, Zhu |
| description | Low vitamin B-12 status alone, or in combination with low folate status, is related to neural tube defects (NTD) and hyperhomocysteinemia, a risk factor for atherosclerotic disease, but little is known about vitamin B-12 status in Chinese adults. In a cross-sectional study, we measured plasma vitamin B-12 in 2407 apparently healthy Chinese men and women, 35-64 y old, living in the south and the north of China. Plasma vitamin B-12 concentrations were lower among the northerners than the southerners (geometric means, 209 vs. 309 pmol/L, P < 0.001). Controlling for gender, age, season (spring and fall), and area (urban and rural) had little impact on the difference. We estimated that 11% of the southerners and 39% of the northerners had plasma vitamin B-12 concentrations |
| doi_str_mv | 10.1093/jn/137.5.1278 |
| format | Article |
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In a cross-sectional study, we measured plasma vitamin B-12 in 2407 apparently healthy Chinese men and women, 35-64 y old, living in the south and the north of China. Plasma vitamin B-12 concentrations were lower among the northerners than the southerners (geometric means, 209 vs. 309 pmol/L, P < 0.001). Controlling for gender, age, season (spring and fall), and area (urban and rural) had little impact on the difference. We estimated that 11% of the southerners and 39% of the northerners had plasma vitamin B-12 concentrations <185 pmol/L, a level to define vitamin B-12 deficiency. Within each region, men had lower plasma vitamin B-12 concentrations and higher prevalence of vitamin B-12 deficiency than women (279 vs. 333 pmol/L and 15 vs. 8% in the south; 192 vs. 233 pmol/L and 47 vs. 34% in the north; P < 0.001 for all the differences). Low intakes of animal-based food, especially fish and dairy products, were significantly associated with vitamin B-12 deficiency. In the north, 59% of the participants were deficient in either folate (<6.8 nmol/L) or vitamin B-12, and 17% had deficiency in both. The corresponding rates were 16 and 1% in the southerners. To our knowledge, our findings provide the first evidence that vitamin B-12 deficiency is common in 35- to 64-y-old Chinese adults, especially in the north. Further studies are needed to evaluate the health effects and possible intervention strategies in areas where B-12 vitamin deficiency is common.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/137.5.1278</identifier><identifier>PMID: 17449593</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutrition</publisher><subject>Adult ; adults ; Age Distribution ; Animals ; Asian People - statistics & numerical data ; Biological and medical sciences ; blood chemistry ; China - epidemiology ; Cross-Sectional Studies ; Dairy Products ; Demography ; Diet ; Feeding. Feeding behavior ; Female ; Fishes ; folic acid ; Folic Acid Deficiency - epidemiology ; food intake ; Fundamental and applied biological sciences. Psychology ; gender differences ; geographical variation ; homocysteine ; Humans ; Male ; men ; Middle Aged ; nutritional status ; Prevalence ; risk factors ; seasonal variation ; Sex Distribution ; spatial variation ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin B 12 Deficiency - epidemiology ; vitamin B12 ; vitamin deficiencies ; women</subject><ispartof>The Journal of nutrition, 2007-05, Vol.137 (5), p.1278-1285</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-202274941ff4c6bdcf9d75bb5ceb70015db8d661f585dc071d0495461949ab7e3</citedby><cites>FETCH-LOGICAL-c415t-202274941ff4c6bdcf9d75bb5ceb70015db8d661f585dc071d0495461949ab7e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18716589$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17449593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hao, Ling</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Zhu, Jianghui</creatorcontrib><creatorcontrib>Stampfer, Meir J</creatorcontrib><creatorcontrib>Tian, Yihua</creatorcontrib><creatorcontrib>Willett, Walter C</creatorcontrib><creatorcontrib>Li, Zhu</creatorcontrib><title>Vitamin B-12 Deficiency Is Prevalent in 35- to 64-Year-Old Chinese Adults</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Low vitamin B-12 status alone, or in combination with low folate status, is related to neural tube defects (NTD) and hyperhomocysteinemia, a risk factor for atherosclerotic disease, but little is known about vitamin B-12 status in Chinese adults. In a cross-sectional study, we measured plasma vitamin B-12 in 2407 apparently healthy Chinese men and women, 35-64 y old, living in the south and the north of China. Plasma vitamin B-12 concentrations were lower among the northerners than the southerners (geometric means, 209 vs. 309 pmol/L, P < 0.001). Controlling for gender, age, season (spring and fall), and area (urban and rural) had little impact on the difference. We estimated that 11% of the southerners and 39% of the northerners had plasma vitamin B-12 concentrations <185 pmol/L, a level to define vitamin B-12 deficiency. Within each region, men had lower plasma vitamin B-12 concentrations and higher prevalence of vitamin B-12 deficiency than women (279 vs. 333 pmol/L and 15 vs. 8% in the south; 192 vs. 233 pmol/L and 47 vs. 34% in the north; P < 0.001 for all the differences). Low intakes of animal-based food, especially fish and dairy products, were significantly associated with vitamin B-12 deficiency. In the north, 59% of the participants were deficient in either folate (<6.8 nmol/L) or vitamin B-12, and 17% had deficiency in both. The corresponding rates were 16 and 1% in the southerners. To our knowledge, our findings provide the first evidence that vitamin B-12 deficiency is common in 35- to 64-y-old Chinese adults, especially in the north. Further studies are needed to evaluate the health effects and possible intervention strategies in areas where B-12 vitamin deficiency is common.</description><subject>Adult</subject><subject>adults</subject><subject>Age Distribution</subject><subject>Animals</subject><subject>Asian People - statistics & numerical data</subject><subject>Biological and medical sciences</subject><subject>blood chemistry</subject><subject>China - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Dairy Products</subject><subject>Demography</subject><subject>Diet</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fishes</subject><subject>folic acid</subject><subject>Folic Acid Deficiency - epidemiology</subject><subject>food intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gender differences</subject><subject>geographical variation</subject><subject>homocysteine</subject><subject>Humans</subject><subject>Male</subject><subject>men</subject><subject>Middle Aged</subject><subject>nutritional status</subject><subject>Prevalence</subject><subject>risk factors</subject><subject>seasonal variation</subject><subject>Sex Distribution</subject><subject>spatial variation</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin B 12 Deficiency - epidemiology</subject><subject>vitamin B12</subject><subject>vitamin deficiencies</subject><subject>women</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtrGzEUBWBRWmrH7bLbVJtmJ0d39BotU-dlMCSQptCV0OjRjBnPONK44H9fGRuyzOou9HF17kHoG9A5UM0u1_0lMDUXc6hU_QFNQXAgEij9iKaUVhVhIOUEneW8ppQC1_VnNAHFuRaaTdHydzvaTdvjnwQqfB1i69rQuz1eZvyYwj_bhX7E5Z0JgscBS07-BJvIQ-fx4qXtQw74yu-6MX9Bn6Ltcvh6mjP0fHvza3FPVg93y8XVijgOYiRVyaS45hAjd7LxLmqvRNMIFxpVAgrf1F5KiKIW3lEFnpaoXILm2jYqsBm6OO7dpuF1F_JoNm12oetsH4ZdNopyYOXMdyFoKbiodIHkCF0ack4hmm1qNzbtDVBzKNmse1NKNsIcSi7-_LR412yCf9OnVgv4cQI2O9vFZHvX5jdXK5CiPnz8_eiiHYz9m4p5fqooMEqVgooz9h-674nN</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Hao, Ling</creator><creator>Ma, Jing</creator><creator>Zhu, Jianghui</creator><creator>Stampfer, Meir J</creator><creator>Tian, Yihua</creator><creator>Willett, Walter C</creator><creator>Li, Zhu</creator><general>American Society for Nutrition</general><general>American Society for Nutritional Sciences</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Vitamin B-12 Deficiency Is Prevalent in 35- to 64-Year-Old Chinese Adults</title><author>Hao, Ling ; Ma, Jing ; Zhu, Jianghui ; Stampfer, Meir J ; Tian, Yihua ; Willett, Walter C ; Li, Zhu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-202274941ff4c6bdcf9d75bb5ceb70015db8d661f585dc071d0495461949ab7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>adults</topic><topic>Age Distribution</topic><topic>Animals</topic><topic>Asian People - statistics & numerical data</topic><topic>Biological and medical sciences</topic><topic>blood chemistry</topic><topic>China - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Dairy Products</topic><topic>Demography</topic><topic>Diet</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fishes</topic><topic>folic acid</topic><topic>Folic Acid Deficiency - epidemiology</topic><topic>food intake</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gender differences</topic><topic>geographical variation</topic><topic>homocysteine</topic><topic>Humans</topic><topic>Male</topic><topic>men</topic><topic>Middle Aged</topic><topic>nutritional status</topic><topic>Prevalence</topic><topic>risk factors</topic><topic>seasonal variation</topic><topic>Sex Distribution</topic><topic>spatial variation</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin B 12 Deficiency - epidemiology</topic><topic>vitamin B12</topic><topic>vitamin deficiencies</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hao, Ling</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Zhu, Jianghui</creatorcontrib><creatorcontrib>Stampfer, Meir J</creatorcontrib><creatorcontrib>Tian, Yihua</creatorcontrib><creatorcontrib>Willett, Walter C</creatorcontrib><creatorcontrib>Li, Zhu</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hao, Ling</au><au>Ma, Jing</au><au>Zhu, Jianghui</au><au>Stampfer, Meir J</au><au>Tian, Yihua</au><au>Willett, Walter C</au><au>Li, Zhu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin B-12 Deficiency Is Prevalent in 35- to 64-Year-Old Chinese Adults</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>137</volume><issue>5</issue><spage>1278</spage><epage>1285</epage><pages>1278-1285</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>Low vitamin B-12 status alone, or in combination with low folate status, is related to neural tube defects (NTD) and hyperhomocysteinemia, a risk factor for atherosclerotic disease, but little is known about vitamin B-12 status in Chinese adults. In a cross-sectional study, we measured plasma vitamin B-12 in 2407 apparently healthy Chinese men and women, 35-64 y old, living in the south and the north of China. Plasma vitamin B-12 concentrations were lower among the northerners than the southerners (geometric means, 209 vs. 309 pmol/L, P < 0.001). Controlling for gender, age, season (spring and fall), and area (urban and rural) had little impact on the difference. We estimated that 11% of the southerners and 39% of the northerners had plasma vitamin B-12 concentrations <185 pmol/L, a level to define vitamin B-12 deficiency. Within each region, men had lower plasma vitamin B-12 concentrations and higher prevalence of vitamin B-12 deficiency than women (279 vs. 333 pmol/L and 15 vs. 8% in the south; 192 vs. 233 pmol/L and 47 vs. 34% in the north; P < 0.001 for all the differences). Low intakes of animal-based food, especially fish and dairy products, were significantly associated with vitamin B-12 deficiency. In the north, 59% of the participants were deficient in either folate (<6.8 nmol/L) or vitamin B-12, and 17% had deficiency in both. The corresponding rates were 16 and 1% in the southerners. To our knowledge, our findings provide the first evidence that vitamin B-12 deficiency is common in 35- to 64-y-old Chinese adults, especially in the north. Further studies are needed to evaluate the health effects and possible intervention strategies in areas where B-12 vitamin deficiency is common.</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutrition</pub><pmid>17449593</pmid><doi>10.1093/jn/137.5.1278</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult adults Age Distribution Animals Asian People - statistics & numerical data Biological and medical sciences blood chemistry China - epidemiology Cross-Sectional Studies Dairy Products Demography Diet Feeding. Feeding behavior Female Fishes folic acid Folic Acid Deficiency - epidemiology food intake Fundamental and applied biological sciences. Psychology gender differences geographical variation homocysteine Humans Male men Middle Aged nutritional status Prevalence risk factors seasonal variation Sex Distribution spatial variation Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin B 12 Deficiency - epidemiology vitamin B12 vitamin deficiencies women |
| title | Vitamin B-12 Deficiency Is Prevalent in 35- to 64-Year-Old Chinese Adults |
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