Ruthenium Porphyrin Compounds for Photodynamic Therapy of Cancer

Five 5,10,15,20-tetra(4-pyridyl)porphyrin (TPP) areneruthenium(II) derivatives and a p-cymeneosmium and two pentamethylcyclopentadienyliridium and -rhodium analogues were prepared and characterized as potential photosensitizing chemotherapeutic agents. The biological effects of all these derivatives...

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Veröffentlicht in:	Journal of medicinal chemistry 2008-03, Vol.51 (6), p.1811-1816
Hauptverfasser:	Schmitt, Frédéric, Govindaswamy, Padavattan, Süss-Fink, Georg, Ang, Wee Han, Dyson, Paul J, Juillerat-Jeanneret, Lucienne, Therrien, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - radiation effects Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects Cytoplasmic Granules - chemistry Dose-Response Relationship, Drug Drug Screening Assays, Antitumor General aspects Humans Lasers Lysosomes - chemistry Medical sciences Melanoma - drug therapy Melanoma - pathology Models, Molecular Molecular Structure Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Organometallic Compounds - radiation effects Pharmacology. Drug treatments Photochemotherapy - methods Photoradiation therapy and photosensitizing agent Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Photosensitizing Agents - radiation effects Porphyrins - chemistry Ruthenium - chemistry Tissue Distribution Treatment with physical agents Treatment. General aspects Tumors
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