Heart Transplantation in Chile: Preliminary Report From the Gustavo Fricke Hospital in Vina del Mar

Abstract Objective The aim of this study was to analyze our results as the national reference center of the public health network in Chile. Patients and Methods Retrospective analysis of all transplantations performed between 1998 and 2005 was done and actuarial survival estimates were calculated ac...

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Veröffentlicht in:Transplantation proceedings 2007-04, Vol.39 (3), p.619-621
Hauptverfasser: Aranguiz-Santander, E, Merello, L, Pedemonte, O, Torres, H, Vera, A, Alburquerque, J
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container_end_page 621
container_issue 3
container_start_page 619
container_title Transplantation proceedings
container_volume 39
creator Aranguiz-Santander, E
Merello, L
Pedemonte, O
Torres, H
Vera, A
Alburquerque, J
description Abstract Objective The aim of this study was to analyze our results as the national reference center of the public health network in Chile. Patients and Methods Retrospective analysis of all transplantations performed between 1998 and 2005 was done and actuarial survival estimates were calculated according to Kaplan-Meier. Results Heart transplantations were performed in 25 patients of mean age 43 ± 11.2 years. Eight patients (32%) were transplanted from a national priority list; all patients were under intensive care support with inotropic therapy, 4 were mechanically ventilated, and 1 required an intra-aortic counter pulsation balloon. The average time on the waiting list was 145 days in nonurgent cases and 9.4 days in urgent ones. Perioperative mortality occurred in 1 patient (4%) due to primary graft failure; 2 patients died due to infectious complications during the first year of follow-up; and 1 died due to a non-cytomegalovirus (CMV) infection at 51 months after transplantation. Two patients developed acute rejection with full recovery. The most common morbidities in the current series were hypertension (71%); hyperlipidemia (71%); renal dysfunction (24%); diabetes (10%); and vasculopathy (10%). Actuarial survival rates were 87.2% and 74.7% at 12 and 86 months, respectively. At 7 years follow-up, 20 patients were in New York Heart Association (NYHA) Class I and one Class II. Conclusion Our heart transplantation program showed comparable results in the short and midterm follow-up when compared with other international reports, confirming that heart transplantation is an excellent therapeutic option for patients with end-stage heart failure.
doi_str_mv 10.1016/j.transproceed.2006.12.024
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Patients and Methods Retrospective analysis of all transplantations performed between 1998 and 2005 was done and actuarial survival estimates were calculated according to Kaplan-Meier. Results Heart transplantations were performed in 25 patients of mean age 43 ± 11.2 years. Eight patients (32%) were transplanted from a national priority list; all patients were under intensive care support with inotropic therapy, 4 were mechanically ventilated, and 1 required an intra-aortic counter pulsation balloon. The average time on the waiting list was 145 days in nonurgent cases and 9.4 days in urgent ones. Perioperative mortality occurred in 1 patient (4%) due to primary graft failure; 2 patients died due to infectious complications during the first year of follow-up; and 1 died due to a non-cytomegalovirus (CMV) infection at 51 months after transplantation. Two patients developed acute rejection with full recovery. The most common morbidities in the current series were hypertension (71%); hyperlipidemia (71%); renal dysfunction (24%); diabetes (10%); and vasculopathy (10%). Actuarial survival rates were 87.2% and 74.7% at 12 and 86 months, respectively. At 7 years follow-up, 20 patients were in New York Heart Association (NYHA) Class I and one Class II. Conclusion Our heart transplantation program showed comparable results in the short and midterm follow-up when compared with other international reports, confirming that heart transplantation is an excellent therapeutic option for patients with end-stage heart failure.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2006.12.024</identifier><identifier>PMID: 17445559</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Chile ; Community Networks ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Heart Transplantation - mortality ; Heart Transplantation - statistics &amp; numerical data ; Humans ; Medical sciences ; Middle Aged ; Miscellaneous ; Postoperative Complications - classification ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Retrospective Studies ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Survival Analysis ; Time Factors ; Tissue, organ and graft immunology ; Treatment Failure ; Treatment Outcome ; Waiting Lists</subject><ispartof>Transplantation proceedings, 2007-04, Vol.39 (3), p.619-621</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-cb556899f35a1d6ad87423c164de52e5470c1a3ab167a55a23188b72ed7dcbc43</citedby><cites>FETCH-LOGICAL-c463t-cb556899f35a1d6ad87423c164de52e5470c1a3ab167a55a23188b72ed7dcbc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041134506015715$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=18880349$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17445559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aranguiz-Santander, E</creatorcontrib><creatorcontrib>Merello, L</creatorcontrib><creatorcontrib>Pedemonte, O</creatorcontrib><creatorcontrib>Torres, H</creatorcontrib><creatorcontrib>Vera, A</creatorcontrib><creatorcontrib>Alburquerque, J</creatorcontrib><title>Heart Transplantation in Chile: Preliminary Report From the Gustavo Fricke Hospital in Vina del Mar</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Objective The aim of this study was to analyze our results as the national reference center of the public health network in Chile. Patients and Methods Retrospective analysis of all transplantations performed between 1998 and 2005 was done and actuarial survival estimates were calculated according to Kaplan-Meier. Results Heart transplantations were performed in 25 patients of mean age 43 ± 11.2 years. Eight patients (32%) were transplanted from a national priority list; all patients were under intensive care support with inotropic therapy, 4 were mechanically ventilated, and 1 required an intra-aortic counter pulsation balloon. The average time on the waiting list was 145 days in nonurgent cases and 9.4 days in urgent ones. Perioperative mortality occurred in 1 patient (4%) due to primary graft failure; 2 patients died due to infectious complications during the first year of follow-up; and 1 died due to a non-cytomegalovirus (CMV) infection at 51 months after transplantation. Two patients developed acute rejection with full recovery. The most common morbidities in the current series were hypertension (71%); hyperlipidemia (71%); renal dysfunction (24%); diabetes (10%); and vasculopathy (10%). Actuarial survival rates were 87.2% and 74.7% at 12 and 86 months, respectively. At 7 years follow-up, 20 patients were in New York Heart Association (NYHA) Class I and one Class II. Conclusion Our heart transplantation program showed comparable results in the short and midterm follow-up when compared with other international reports, confirming that heart transplantation is an excellent therapeutic option for patients with end-stage heart failure.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chile</subject><subject>Community Networks</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Heart Transplantation - mortality</subject><subject>Heart Transplantation - statistics &amp; numerical data</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Postoperative Complications - classification</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Survival Analysis</subject><subject>Time Factors</subject><subject>Tissue, organ and graft immunology</subject><subject>Treatment Failure</subject><subject>Treatment Outcome</subject><subject>Waiting Lists</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl1rFDEUhoModq3-BQmC3s2Yk4_JbC8EWW1XqChavQ2ZzFma7exkTTKF_vtmuouKV16FJM97Ts5DCHkFrAYGzdttnaMd0z4Gh9jXnLGmBl4zLh-RBbRaVLzh4jFZMCahAiHVCXmW0paVPZfiKTkBLaVSarkgbo02Znr1UHCwY7bZh5H6ka6u_YBn9GvEwe_8aOMd_Yb7UODzGHY0XyO9mFK2t6EceHeDdB3S3mc7zOmfJUF7HOhnG5-TJxs7JHxxXE_Jj_OPV6t1dfnl4tPq_WXlZCNy5Tqlmna53AhloW9s32rJhYNG9qg4KqmZAytsB422SlkuoG07zbHXveucFKfkzaFuMfNrwpTNzieHQxkLw5SMLjpA6raAZwfQxZBSxI3ZR78rExpgZlZstuZvxWZWbICboriEXx67TN2u3P2OHp0W4PURsMnZYVMKOZ_-cG3bMiFn7sOBw-Lk1mM0yXkcHfY-osumD_7_3vPunzJu8KMvnW_wDtM2THEs1g2YVALm-_wp5j_BGgZKgxL3rUG14Q</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Aranguiz-Santander, E</creator><creator>Merello, L</creator><creator>Pedemonte, O</creator><creator>Torres, H</creator><creator>Vera, A</creator><creator>Alburquerque, J</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>Heart Transplantation in Chile: Preliminary Report From the Gustavo Fricke Hospital in Vina del Mar</title><author>Aranguiz-Santander, E ; Merello, L ; Pedemonte, O ; Torres, H ; Vera, A ; Alburquerque, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-cb556899f35a1d6ad87423c164de52e5470c1a3ab167a55a23188b72ed7dcbc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chile</topic><topic>Community Networks</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Heart Transplantation - mortality</topic><topic>Heart Transplantation - statistics &amp; numerical data</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Postoperative Complications - classification</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Survival Analysis</topic><topic>Time Factors</topic><topic>Tissue, organ and graft immunology</topic><topic>Treatment Failure</topic><topic>Treatment Outcome</topic><topic>Waiting Lists</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aranguiz-Santander, E</creatorcontrib><creatorcontrib>Merello, L</creatorcontrib><creatorcontrib>Pedemonte, O</creatorcontrib><creatorcontrib>Torres, H</creatorcontrib><creatorcontrib>Vera, A</creatorcontrib><creatorcontrib>Alburquerque, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aranguiz-Santander, E</au><au>Merello, L</au><au>Pedemonte, O</au><au>Torres, H</au><au>Vera, A</au><au>Alburquerque, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heart Transplantation in Chile: Preliminary Report From the Gustavo Fricke Hospital in Vina del Mar</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>39</volume><issue>3</issue><spage>619</spage><epage>621</epage><pages>619-621</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract Objective The aim of this study was to analyze our results as the national reference center of the public health network in Chile. Patients and Methods Retrospective analysis of all transplantations performed between 1998 and 2005 was done and actuarial survival estimates were calculated according to Kaplan-Meier. Results Heart transplantations were performed in 25 patients of mean age 43 ± 11.2 years. Eight patients (32%) were transplanted from a national priority list; all patients were under intensive care support with inotropic therapy, 4 were mechanically ventilated, and 1 required an intra-aortic counter pulsation balloon. The average time on the waiting list was 145 days in nonurgent cases and 9.4 days in urgent ones. Perioperative mortality occurred in 1 patient (4%) due to primary graft failure; 2 patients died due to infectious complications during the first year of follow-up; and 1 died due to a non-cytomegalovirus (CMV) infection at 51 months after transplantation. Two patients developed acute rejection with full recovery. The most common morbidities in the current series were hypertension (71%); hyperlipidemia (71%); renal dysfunction (24%); diabetes (10%); and vasculopathy (10%). Actuarial survival rates were 87.2% and 74.7% at 12 and 86 months, respectively. At 7 years follow-up, 20 patients were in New York Heart Association (NYHA) Class I and one Class II. Conclusion Our heart transplantation program showed comparable results in the short and midterm follow-up when compared with other international reports, confirming that heart transplantation is an excellent therapeutic option for patients with end-stage heart failure.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17445559</pmid><doi>10.1016/j.transproceed.2006.12.024</doi><tpages>3</tpages></addata></record>
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subjects Adult
Biological and medical sciences
Chile
Community Networks
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Heart Transplantation - mortality
Heart Transplantation - statistics & numerical data
Humans
Medical sciences
Middle Aged
Miscellaneous
Postoperative Complications - classification
Public health. Hygiene
Public health. Hygiene-occupational medicine
Retrospective Studies
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Survival Analysis
Time Factors
Tissue, organ and graft immunology
Treatment Failure
Treatment Outcome
Waiting Lists
title Heart Transplantation in Chile: Preliminary Report From the Gustavo Fricke Hospital in Vina del Mar
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