Calcitonin gene-related peptide-mediated cardioprotection of postconditioning in isolated rat hearts
Previous studies have demonstrated that endogenous calcitonin gene-related peptide (CGRP) plays an important role in mediation of ischemic preconditioning. In the present study, we tested whether CGRP is also involved in mediation of the protective effects of postconditioning in isolated rat hearts....
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| Veröffentlicht in: | Regulatory peptides 2008-04, Vol.147 (1-3), p.4-8 |
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| creator | Li, Dai Li, Nian-Sheng Chen, Qing-Quan Guo, Ren Xu, Ping-Sheng Deng, Han-Wu Li, Yuan-Jian |
| description | Previous studies have demonstrated that endogenous calcitonin gene-related peptide (CGRP) plays an important role in mediation of ischemic preconditioning. In the present study, we tested whether CGRP is also involved in mediation of the protective effects of postconditioning in isolated rat hearts. Sixty minutes of left coronary artery occlusion and followed by 60 min of reperfusion caused a significant decrease in cardiac function and a significant increase in creatine kinase (CK) release and infarct size. Postconditioning with three cycles of 1-min ischemia and 1-min reperfusion produced a marked improvement of cardiac function and decreased CK release and infarct size, concomitantly with an increase in the release of CGRP release in coronary effluent. However, the cardioprotection afforded by postconditioning was abolished by CGRP 8-37 (10−7 M), a selective CGRP receptor antagonist, or pretreatment with capsaicin (50 mg/kg, s.c.), which depletes transmitters in sensory nerves. Exogenous CGRP (5×10−9 M) administration of CGRP reappeared postconditioning-like cardioprotection in the rats pretreated with capsaicin. These results suggest that the protective effects of ischemic postconditioning are related to stimulation of endogenous CGRP release in rat hearts. |
| doi_str_mv | 10.1016/j.regpep.2007.11.004 |
| format | Article |
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In the present study, we tested whether CGRP is also involved in mediation of the protective effects of postconditioning in isolated rat hearts. Sixty minutes of left coronary artery occlusion and followed by 60 min of reperfusion caused a significant decrease in cardiac function and a significant increase in creatine kinase (CK) release and infarct size. Postconditioning with three cycles of 1-min ischemia and 1-min reperfusion produced a marked improvement of cardiac function and decreased CK release and infarct size, concomitantly with an increase in the release of CGRP release in coronary effluent. However, the cardioprotection afforded by postconditioning was abolished by CGRP 8-37 (10−7 M), a selective CGRP receptor antagonist, or pretreatment with capsaicin (50 mg/kg, s.c.), which depletes transmitters in sensory nerves. Exogenous CGRP (5×10−9 M) administration of CGRP reappeared postconditioning-like cardioprotection in the rats pretreated with capsaicin. These results suggest that the protective effects of ischemic postconditioning are related to stimulation of endogenous CGRP release in rat hearts.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/j.regpep.2007.11.004</identifier><identifier>PMID: 18166234</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Calcitonin gene-related peptide ; Calcitonin Gene-Related Peptide - metabolism ; Calcitonin Gene-Related Peptide - therapeutic use ; Cardiology. Vascular system ; Creatine Kinase - metabolism ; Fundamental and applied biological sciences. Psychology ; Heart - drug effects ; Ischemia-reperfusion ; Ischemic Preconditioning, Myocardial ; Male ; Medical sciences ; Myocardial Reperfusion ; Myocardial Reperfusion Injury - physiopathology ; Myocardial Reperfusion Injury - prevention & control ; Postconditioning ; Rat ; Rats ; Rats, Sprague-Dawley ; Ventricular Function, Left ; Vertebrates: endocrinology</subject><ispartof>Regulatory peptides, 2008-04, Vol.147 (1-3), p.4-8</ispartof><rights>2007 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-df5493f3583e1b2c0c40f0ba10ac7b83c797407e54c5286e045a713481cb07b03</citedby><cites>FETCH-LOGICAL-c416t-df5493f3583e1b2c0c40f0ba10ac7b83c797407e54c5286e045a713481cb07b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167011507002303$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20249129$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18166234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Dai</creatorcontrib><creatorcontrib>Li, Nian-Sheng</creatorcontrib><creatorcontrib>Chen, Qing-Quan</creatorcontrib><creatorcontrib>Guo, Ren</creatorcontrib><creatorcontrib>Xu, Ping-Sheng</creatorcontrib><creatorcontrib>Deng, Han-Wu</creatorcontrib><creatorcontrib>Li, Yuan-Jian</creatorcontrib><title>Calcitonin gene-related peptide-mediated cardioprotection of postconditioning in isolated rat hearts</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>Previous studies have demonstrated that endogenous calcitonin gene-related peptide (CGRP) plays an important role in mediation of ischemic preconditioning. In the present study, we tested whether CGRP is also involved in mediation of the protective effects of postconditioning in isolated rat hearts. Sixty minutes of left coronary artery occlusion and followed by 60 min of reperfusion caused a significant decrease in cardiac function and a significant increase in creatine kinase (CK) release and infarct size. Postconditioning with three cycles of 1-min ischemia and 1-min reperfusion produced a marked improvement of cardiac function and decreased CK release and infarct size, concomitantly with an increase in the release of CGRP release in coronary effluent. However, the cardioprotection afforded by postconditioning was abolished by CGRP 8-37 (10−7 M), a selective CGRP receptor antagonist, or pretreatment with capsaicin (50 mg/kg, s.c.), which depletes transmitters in sensory nerves. Exogenous CGRP (5×10−9 M) administration of CGRP reappeared postconditioning-like cardioprotection in the rats pretreated with capsaicin. These results suggest that the protective effects of ischemic postconditioning are related to stimulation of endogenous CGRP release in rat hearts.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcitonin gene-related peptide</subject><subject>Calcitonin Gene-Related Peptide - metabolism</subject><subject>Calcitonin Gene-Related Peptide - therapeutic use</subject><subject>Cardiology. Vascular system</subject><subject>Creatine Kinase - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart - drug effects</subject><subject>Ischemia-reperfusion</subject><subject>Ischemic Preconditioning, Myocardial</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardial Reperfusion</subject><subject>Myocardial Reperfusion Injury - physiopathology</subject><subject>Myocardial Reperfusion Injury - prevention & control</subject><subject>Postconditioning</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Ventricular Function, Left</subject><subject>Vertebrates: endocrinology</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQQEVpaDYf_6AUX5qbnRlLtryXQFnSJBDIpT0LWR5vtXglR9IW8u-jrZf21tPA8OYxPMY-I1QI2N7uqkDbmeaqBpAVYgUgPrAVdpKX2HbtR7bKmCwBsTlnFzHuALCRkn9i59hh29ZcrNiw0ZOxyTvrii05KgNNOtFQZHOyA5V7GuyfhdFhsH4OPpFJ1rvCj8XsYzLeDfa4sG5bZIuNfjEEnYpfpEOKV-xs1FOk69O8ZD-_3__YPJbPLw9Pm2_PpRHYpnIYG7HmI286TtjXBoyAEXqNoI3sO27kWgqQ1AjT1F1LIBotkYsOTQ-yB37JbhZv_vL1QDGpvY2Gpkk78oeoJAiEpsMMigU0wccYaFRzsHsd3hSCOtZVO7XUVce6ClHluvnsy8l_6HOXf0ennBn4egJ0NHoag3bGxr9cDbVYY73O3N3CUa7x21JQ0VhyJrcOua4avP3_J-8Cb5tZ</recordid><startdate>20080410</startdate><enddate>20080410</enddate><creator>Li, Dai</creator><creator>Li, Nian-Sheng</creator><creator>Chen, Qing-Quan</creator><creator>Guo, Ren</creator><creator>Xu, Ping-Sheng</creator><creator>Deng, Han-Wu</creator><creator>Li, Yuan-Jian</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080410</creationdate><title>Calcitonin gene-related peptide-mediated cardioprotection of postconditioning in isolated rat hearts</title><author>Li, Dai ; Li, Nian-Sheng ; Chen, Qing-Quan ; Guo, Ren ; Xu, Ping-Sheng ; Deng, Han-Wu ; Li, Yuan-Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-df5493f3583e1b2c0c40f0ba10ac7b83c797407e54c5286e045a713481cb07b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcitonin gene-related peptide</topic><topic>Calcitonin Gene-Related Peptide - metabolism</topic><topic>Calcitonin Gene-Related Peptide - therapeutic use</topic><topic>Cardiology. Vascular system</topic><topic>Creatine Kinase - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart - drug effects</topic><topic>Ischemia-reperfusion</topic><topic>Ischemic Preconditioning, Myocardial</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocardial Reperfusion</topic><topic>Myocardial Reperfusion Injury - physiopathology</topic><topic>Myocardial Reperfusion Injury - prevention & control</topic><topic>Postconditioning</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Ventricular Function, Left</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Dai</creatorcontrib><creatorcontrib>Li, Nian-Sheng</creatorcontrib><creatorcontrib>Chen, Qing-Quan</creatorcontrib><creatorcontrib>Guo, Ren</creatorcontrib><creatorcontrib>Xu, Ping-Sheng</creatorcontrib><creatorcontrib>Deng, Han-Wu</creatorcontrib><creatorcontrib>Li, Yuan-Jian</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Dai</au><au>Li, Nian-Sheng</au><au>Chen, Qing-Quan</au><au>Guo, Ren</au><au>Xu, Ping-Sheng</au><au>Deng, Han-Wu</au><au>Li, Yuan-Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcitonin gene-related peptide-mediated cardioprotection of postconditioning in isolated rat hearts</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>2008-04-10</date><risdate>2008</risdate><volume>147</volume><issue>1-3</issue><spage>4</spage><epage>8</epage><pages>4-8</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>Previous studies have demonstrated that endogenous calcitonin gene-related peptide (CGRP) plays an important role in mediation of ischemic preconditioning. In the present study, we tested whether CGRP is also involved in mediation of the protective effects of postconditioning in isolated rat hearts. Sixty minutes of left coronary artery occlusion and followed by 60 min of reperfusion caused a significant decrease in cardiac function and a significant increase in creatine kinase (CK) release and infarct size. Postconditioning with three cycles of 1-min ischemia and 1-min reperfusion produced a marked improvement of cardiac function and decreased CK release and infarct size, concomitantly with an increase in the release of CGRP release in coronary effluent. However, the cardioprotection afforded by postconditioning was abolished by CGRP 8-37 (10−7 M), a selective CGRP receptor antagonist, or pretreatment with capsaicin (50 mg/kg, s.c.), which depletes transmitters in sensory nerves. Exogenous CGRP (5×10−9 M) administration of CGRP reappeared postconditioning-like cardioprotection in the rats pretreated with capsaicin. These results suggest that the protective effects of ischemic postconditioning are related to stimulation of endogenous CGRP release in rat hearts.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18166234</pmid><doi>10.1016/j.regpep.2007.11.004</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Calcitonin gene-related peptide Calcitonin Gene-Related Peptide - metabolism Calcitonin Gene-Related Peptide - therapeutic use Cardiology. Vascular system Creatine Kinase - metabolism Fundamental and applied biological sciences. Psychology Heart - drug effects Ischemia-reperfusion Ischemic Preconditioning, Myocardial Male Medical sciences Myocardial Reperfusion Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Postconditioning Rat Rats Rats, Sprague-Dawley Ventricular Function, Left Vertebrates: endocrinology |
| title | Calcitonin gene-related peptide-mediated cardioprotection of postconditioning in isolated rat hearts |
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