Primary prostatic central zone adenocarcinoma
The central zone (CZ) of the prostate is embryologically, anatomically, and histologically distinct. High-grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma (PAC) are encountered in the CZ, but have not been well studied. Non-CZ PAC that spread into the CZ can mimic CZ PA...
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| Veröffentlicht in: | Pathology, research and practice research and practice, 2008-01, Vol.204 (4), p.251-258 |
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| creator | Mai, Kien T. Belanger, Eric C. Al-Maghrabi, Hatim M. Robertson, Susan Wang, Don Margnean, Celia |
| description | The central zone (CZ) of the prostate is embryologically, anatomically, and histologically distinct. High-grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma (PAC) are encountered in the CZ, but have not been well studied. Non-CZ PAC that spread into the CZ can mimic CZ PAC.
We reviewed 300 consecutive radical prostatectomies performed for PAC to identify cases showing PAC and HGPIN in the CZ.
There were nine PAC (3%) localized predominantly in the CZ, presenting as a single tumor nodule (8/9) and associated with 4.5±1.1 foci HGPIN in the CZ and with only 1.7±0.5 foci in the PZ. Of the 291 non-CZ PAC, 24 cases showed satellite tumor nodules in the CZ, and 92 cases demonstrated secondary contiguous spread to the CZ. As compared to the non-CZ PAC, CZ PAC tended to have lower tumor volume, but had higher Gleason scores (8.10±0.6 vs. 6.30±0.7,
p |
| doi_str_mv | 10.1016/j.prp.2007.11.002 |
| format | Article |
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We reviewed 300 consecutive radical prostatectomies performed for PAC to identify cases showing PAC and HGPIN in the CZ.
There were nine PAC (3%) localized predominantly in the CZ, presenting as a single tumor nodule (8/9) and associated with 4.5±1.1 foci HGPIN in the CZ and with only 1.7±0.5 foci in the PZ. Of the 291 non-CZ PAC, 24 cases showed satellite tumor nodules in the CZ, and 92 cases demonstrated secondary contiguous spread to the CZ. As compared to the non-CZ PAC, CZ PAC tended to have lower tumor volume, but had higher Gleason scores (8.10±0.6 vs. 6.30±0.7,
p<0.05), as well as a higher incidence of a ductal carcinoma component (6/9), higher rates of capsular penetration, positive resection margins (4/9), and seminal vesicle spread (2/9). The CZ HGPIN associated with CZ PAC demonstrated cells with prominent nucleoli and formed either slender papillary structures or cribriform/solid patterns. The correlating positive biopsy cores were from the mid portion or from base of prostate and contained foci of HGPIN in 4/7 cases.
The CZ PAC is characteristically accompanied by more foci of HGPIN in the CZ than in non-CZ and is associated with high grade and high stage. Preoperative diagnosis of CZ PAC can be suspected due to the histopathological features in the biopsy and is important to improve the free surgical resection rate.</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/j.prp.2007.11.002</identifier><identifier>PMID: 18178014</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adenocarcinoma ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Aged ; Biopsy ; Carcinoma, Ductal - pathology ; Carcinoma, Ductal - surgery ; Central zone ; Humans ; Intraepithelial neoplasia ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Prostate ; Prostate - pathology ; Prostate - surgery ; Prostatectomy ; Prostatic Intraepithelial Neoplasia - pathology ; Prostatic Intraepithelial Neoplasia - surgery ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Seminal Vesicles - pathology</subject><ispartof>Pathology, research and practice, 2008-01, Vol.204 (4), p.251-258</ispartof><rights>2007 Elsevier GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-c2b640f550e35fe695b933153c4cb64928053921f9c37b09aebb25e10ff365cd3</citedby><cites>FETCH-LOGICAL-c351t-c2b640f550e35fe695b933153c4cb64928053921f9c37b09aebb25e10ff365cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.prp.2007.11.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18178014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mai, Kien T.</creatorcontrib><creatorcontrib>Belanger, Eric C.</creatorcontrib><creatorcontrib>Al-Maghrabi, Hatim M.</creatorcontrib><creatorcontrib>Robertson, Susan</creatorcontrib><creatorcontrib>Wang, Don</creatorcontrib><creatorcontrib>Margnean, Celia</creatorcontrib><title>Primary prostatic central zone adenocarcinoma</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>The central zone (CZ) of the prostate is embryologically, anatomically, and histologically distinct. High-grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma (PAC) are encountered in the CZ, but have not been well studied. Non-CZ PAC that spread into the CZ can mimic CZ PAC.
We reviewed 300 consecutive radical prostatectomies performed for PAC to identify cases showing PAC and HGPIN in the CZ.
There were nine PAC (3%) localized predominantly in the CZ, presenting as a single tumor nodule (8/9) and associated with 4.5±1.1 foci HGPIN in the CZ and with only 1.7±0.5 foci in the PZ. Of the 291 non-CZ PAC, 24 cases showed satellite tumor nodules in the CZ, and 92 cases demonstrated secondary contiguous spread to the CZ. As compared to the non-CZ PAC, CZ PAC tended to have lower tumor volume, but had higher Gleason scores (8.10±0.6 vs. 6.30±0.7,
p<0.05), as well as a higher incidence of a ductal carcinoma component (6/9), higher rates of capsular penetration, positive resection margins (4/9), and seminal vesicle spread (2/9). The CZ HGPIN associated with CZ PAC demonstrated cells with prominent nucleoli and formed either slender papillary structures or cribriform/solid patterns. The correlating positive biopsy cores were from the mid portion or from base of prostate and contained foci of HGPIN in 4/7 cases.
The CZ PAC is characteristically accompanied by more foci of HGPIN in the CZ than in non-CZ and is associated with high grade and high stage. Preoperative diagnosis of CZ PAC can be suspected due to the histopathological features in the biopsy and is important to improve the free surgical resection rate.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Aged</subject><subject>Biopsy</subject><subject>Carcinoma, Ductal - pathology</subject><subject>Carcinoma, Ductal - surgery</subject><subject>Central zone</subject><subject>Humans</subject><subject>Intraepithelial neoplasia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Prostate</subject><subject>Prostate - pathology</subject><subject>Prostate - surgery</subject><subject>Prostatectomy</subject><subject>Prostatic Intraepithelial Neoplasia - pathology</subject><subject>Prostatic Intraepithelial Neoplasia - surgery</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Seminal Vesicles - pathology</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxEAQhAdR3HX1B3iRnLwldmcy2QRPIr5gQQ96HiadDsySlzNZQX-9s2TBm6eG7q-KrhLiEiFBwPxmm4xuTFKAdYKYAKRHYok5FjHkEo_FEmSWxSBlsRBn3m8hgJDhqVhggesCMFuK-M3ZzrjvaHSDn8xkKSLuJ2fa6GfoOTI19wMZR7YfOnMuThrTer44zJX4eHx4v3-ON69PL_d3m5ikwimmtMozaJQClqrhvFRVKSUqSRmFS5kWoGSZYlOSXFdQGq6qVDFC08hcUS1X4nr2DV997thPurOeuG1Nz8PO630MwDILIM4ghfe940aPcx6NoPcd6W3YjHrfkUbUoaOguTqY76qO6z_FoZQA3M4Ah4hflp32ZLknrq1jmnQ92H_sfwHrs3YW</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Mai, Kien T.</creator><creator>Belanger, Eric C.</creator><creator>Al-Maghrabi, Hatim M.</creator><creator>Robertson, Susan</creator><creator>Wang, Don</creator><creator>Margnean, Celia</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Primary prostatic central zone adenocarcinoma</title><author>Mai, Kien T. ; Belanger, Eric C. ; Al-Maghrabi, Hatim M. ; Robertson, Susan ; Wang, Don ; Margnean, Celia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-c2b640f550e35fe695b933153c4cb64928053921f9c37b09aebb25e10ff365cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Aged</topic><topic>Biopsy</topic><topic>Carcinoma, Ductal - pathology</topic><topic>Carcinoma, Ductal - surgery</topic><topic>Central zone</topic><topic>Humans</topic><topic>Intraepithelial neoplasia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Prostate</topic><topic>Prostate - pathology</topic><topic>Prostate - surgery</topic><topic>Prostatectomy</topic><topic>Prostatic Intraepithelial Neoplasia - pathology</topic><topic>Prostatic Intraepithelial Neoplasia - surgery</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Seminal Vesicles - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mai, Kien T.</creatorcontrib><creatorcontrib>Belanger, Eric C.</creatorcontrib><creatorcontrib>Al-Maghrabi, Hatim M.</creatorcontrib><creatorcontrib>Robertson, Susan</creatorcontrib><creatorcontrib>Wang, Don</creatorcontrib><creatorcontrib>Margnean, Celia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mai, Kien T.</au><au>Belanger, Eric C.</au><au>Al-Maghrabi, Hatim M.</au><au>Robertson, Susan</au><au>Wang, Don</au><au>Margnean, Celia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary prostatic central zone adenocarcinoma</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>204</volume><issue>4</issue><spage>251</spage><epage>258</epage><pages>251-258</pages><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>The central zone (CZ) of the prostate is embryologically, anatomically, and histologically distinct. High-grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma (PAC) are encountered in the CZ, but have not been well studied. Non-CZ PAC that spread into the CZ can mimic CZ PAC.
We reviewed 300 consecutive radical prostatectomies performed for PAC to identify cases showing PAC and HGPIN in the CZ.
There were nine PAC (3%) localized predominantly in the CZ, presenting as a single tumor nodule (8/9) and associated with 4.5±1.1 foci HGPIN in the CZ and with only 1.7±0.5 foci in the PZ. Of the 291 non-CZ PAC, 24 cases showed satellite tumor nodules in the CZ, and 92 cases demonstrated secondary contiguous spread to the CZ. As compared to the non-CZ PAC, CZ PAC tended to have lower tumor volume, but had higher Gleason scores (8.10±0.6 vs. 6.30±0.7,
p<0.05), as well as a higher incidence of a ductal carcinoma component (6/9), higher rates of capsular penetration, positive resection margins (4/9), and seminal vesicle spread (2/9). The CZ HGPIN associated with CZ PAC demonstrated cells with prominent nucleoli and formed either slender papillary structures or cribriform/solid patterns. The correlating positive biopsy cores were from the mid portion or from base of prostate and contained foci of HGPIN in 4/7 cases.
The CZ PAC is characteristically accompanied by more foci of HGPIN in the CZ than in non-CZ and is associated with high grade and high stage. Preoperative diagnosis of CZ PAC can be suspected due to the histopathological features in the biopsy and is important to improve the free surgical resection rate.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>18178014</pmid><doi>10.1016/j.prp.2007.11.002</doi><tpages>8</tpages></addata></record> |
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| subjects | Adenocarcinoma Adenocarcinoma - pathology Adenocarcinoma - surgery Aged Biopsy Carcinoma, Ductal - pathology Carcinoma, Ductal - surgery Central zone Humans Intraepithelial neoplasia Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Prostate Prostate - pathology Prostate - surgery Prostatectomy Prostatic Intraepithelial Neoplasia - pathology Prostatic Intraepithelial Neoplasia - surgery Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Seminal Vesicles - pathology |
| title | Primary prostatic central zone adenocarcinoma |
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