Insight and psychopathology in never-treated schizophrenia
Abstract Insight is a feature of schizophrenia related to psychopathology, which could be modified by treatment. The real relationship will be more evident in the never-treated state. This study compared insight and its relationship to psychopathology in 143 never-treated patients with chronic schiz...
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| Veröffentlicht in: | Comprehensive psychiatry 2007-05, Vol.48 (3), p.264-268 |
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| creator | Tirupati, Srinivasan Padmavati, Raman Thara, Rangaswamy McCreadie, Robin G |
| description | Abstract Insight is a feature of schizophrenia related to psychopathology, which could be modified by treatment. The real relationship will be more evident in the never-treated state. This study compared insight and its relationship to psychopathology in 143 never-treated patients with chronic schizophrenia with 183 treated patients. The treated patients had not received any structured intervention for improvement of insight. The item on insight and judgment from the Positive and Negative Syndrome Scale for schizophrenia was used as a measure of insight. Never-treated patients were more ill and poorer in insight than the TT group. Sex, age, duration of illness, negative symptoms related to insight only in the TT group. Positive symptoms score correlated with insight in both the groups, but negative symptoms correlated with insight only among the treated patients. Delusions, uncooperativeness, and poor attention predicted 27% of variation in the level of insight in the never-treated, whereas age; duration of illness; and symptoms of emotional withdrawal, difficulty in abstract thinking, and uncooperativeness predicted 30.3% of variation in insight of the TT group. The observed differences between the never-treated and treated subjects were due to influence of treatment on the association between insight and psychopathology. A subgroup of patients with a treatment-resistant trait of negative symptoms associated with poor insight was hypothesized. |
| doi_str_mv | 10.1016/j.comppsych.2006.10.006 |
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The real relationship will be more evident in the never-treated state. This study compared insight and its relationship to psychopathology in 143 never-treated patients with chronic schizophrenia with 183 treated patients. The treated patients had not received any structured intervention for improvement of insight. The item on insight and judgment from the Positive and Negative Syndrome Scale for schizophrenia was used as a measure of insight. Never-treated patients were more ill and poorer in insight than the TT group. Sex, age, duration of illness, negative symptoms related to insight only in the TT group. Positive symptoms score correlated with insight in both the groups, but negative symptoms correlated with insight only among the treated patients. Delusions, uncooperativeness, and poor attention predicted 27% of variation in the level of insight in the never-treated, whereas age; duration of illness; and symptoms of emotional withdrawal, difficulty in abstract thinking, and uncooperativeness predicted 30.3% of variation in insight of the TT group. The observed differences between the never-treated and treated subjects were due to influence of treatment on the association between insight and psychopathology. A subgroup of patients with a treatment-resistant trait of negative symptoms associated with poor insight was hypothesized.</description><identifier>ISSN: 0010-440X</identifier><identifier>EISSN: 1532-8384</identifier><identifier>DOI: 10.1016/j.comppsych.2006.10.006</identifier><identifier>PMID: 17445521</identifier><identifier>CODEN: COPYAV</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Age Factors ; Agonistic Behavior ; Anxiety ; Attention ; Awareness ; Biological and medical sciences ; Delusions - psychology ; Female ; Humans ; Male ; Medical sciences ; Mental disorders ; Middle Aged ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology ; Psychopathology. Psychiatry ; Psychoses ; Psychotropic drugs ; Regression Analysis ; Schizophrenia ; Schizophrenia - therapy ; Schizophrenic Psychology ; Studies ; Substance abuse treatment ; Time Factors</subject><ispartof>Comprehensive psychiatry, 2007-05, Vol.48 (3), p.264-268</ispartof><rights>2007</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Elsevier Limited May 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-8599f738e6c490c1fd50fd3334e42b55ee322a777b26b35a995e8a7e6b99c72a3</citedby><cites>FETCH-LOGICAL-c482t-8599f738e6c490c1fd50fd3334e42b55ee322a777b26b35a995e8a7e6b99c72a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1030086057?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18759252$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17445521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tirupati, Srinivasan</creatorcontrib><creatorcontrib>Padmavati, Raman</creatorcontrib><creatorcontrib>Thara, Rangaswamy</creatorcontrib><creatorcontrib>McCreadie, Robin G</creatorcontrib><title>Insight and psychopathology in never-treated schizophrenia</title><title>Comprehensive psychiatry</title><addtitle>Compr Psychiatry</addtitle><description>Abstract Insight is a feature of schizophrenia related to psychopathology, which could be modified by treatment. The real relationship will be more evident in the never-treated state. This study compared insight and its relationship to psychopathology in 143 never-treated patients with chronic schizophrenia with 183 treated patients. The treated patients had not received any structured intervention for improvement of insight. The item on insight and judgment from the Positive and Negative Syndrome Scale for schizophrenia was used as a measure of insight. Never-treated patients were more ill and poorer in insight than the TT group. Sex, age, duration of illness, negative symptoms related to insight only in the TT group. Positive symptoms score correlated with insight in both the groups, but negative symptoms correlated with insight only among the treated patients. Delusions, uncooperativeness, and poor attention predicted 27% of variation in the level of insight in the never-treated, whereas age; duration of illness; and symptoms of emotional withdrawal, difficulty in abstract thinking, and uncooperativeness predicted 30.3% of variation in insight of the TT group. The observed differences between the never-treated and treated subjects were due to influence of treatment on the association between insight and psychopathology. 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Psychiatry</subject><subject>Psychoses</subject><subject>Psychotropic drugs</subject><subject>Regression Analysis</subject><subject>Schizophrenia</subject><subject>Schizophrenia - therapy</subject><subject>Schizophrenic Psychology</subject><subject>Studies</subject><subject>Substance abuse treatment</subject><subject>Time Factors</subject><issn>0010-440X</issn><issn>1532-8384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk9v1DAQxS0EokvhK0AkBLcsE_-JHQ6VqopCpUocAImb5TiTxkvWDna20vLpcborVuqJ07Ps3zzPPA0hbypYV1DVHzZrG7bTlPZ2WFOAOt-uszwhq0owWiqm-FOyAqig5Bx-npEXKW0AQCnFn5OzSnIuBK1W5OONT-5umAvju-LBL0xmHsIY7vaF84XHe4zlHNHM2BXJDu5PmIaI3pmX5FlvxoSvjnpOflx_-n71pbz9-vnm6vK2tFzRuVSiaXrJFNaWN2CrvhPQd4wxjpy2QiAySo2UsqV1y4RpGoHKSKzbprGSGnZO3h98pxh-7zDNeuuSxXE0HsMuaQkcGinrDL59BG7CLvrcm66A5eFrEDJT8kDZGFKK2Ospuq2J-wzpJVy90f_C1Uu4y0OWXPn66L9rt9id6o5pZuDdETDJmrGPxluXTpySoqGCZu7ywGGO7d5h1Mk69BY7F9HOugvuP5q5eORhR-dd_vYX7jGdJteJatDfll1YVgHqfKK8Zn8BHZKwSg</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Tirupati, Srinivasan</creator><creator>Padmavati, Raman</creator><creator>Thara, Rangaswamy</creator><creator>McCreadie, Robin G</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Insight and psychopathology in never-treated schizophrenia</title><author>Tirupati, Srinivasan ; Padmavati, Raman ; Thara, Rangaswamy ; McCreadie, Robin G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-8599f738e6c490c1fd50fd3334e42b55ee322a777b26b35a995e8a7e6b99c72a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age Factors</topic><topic>Agonistic Behavior</topic><topic>Anxiety</topic><topic>Attention</topic><topic>Awareness</topic><topic>Biological and medical sciences</topic><topic>Delusions - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental disorders</topic><topic>Middle Aged</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology</topic><topic>Psychopathology. 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The real relationship will be more evident in the never-treated state. This study compared insight and its relationship to psychopathology in 143 never-treated patients with chronic schizophrenia with 183 treated patients. The treated patients had not received any structured intervention for improvement of insight. The item on insight and judgment from the Positive and Negative Syndrome Scale for schizophrenia was used as a measure of insight. Never-treated patients were more ill and poorer in insight than the TT group. Sex, age, duration of illness, negative symptoms related to insight only in the TT group. Positive symptoms score correlated with insight in both the groups, but negative symptoms correlated with insight only among the treated patients. Delusions, uncooperativeness, and poor attention predicted 27% of variation in the level of insight in the never-treated, whereas age; duration of illness; and symptoms of emotional withdrawal, difficulty in abstract thinking, and uncooperativeness predicted 30.3% of variation in insight of the TT group. The observed differences between the never-treated and treated subjects were due to influence of treatment on the association between insight and psychopathology. A subgroup of patients with a treatment-resistant trait of negative symptoms associated with poor insight was hypothesized.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17445521</pmid><doi>10.1016/j.comppsych.2006.10.006</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Age Factors Agonistic Behavior Anxiety Attention Awareness Biological and medical sciences Delusions - psychology Female Humans Male Medical sciences Mental disorders Middle Aged Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology Psychopathology. Psychiatry Psychoses Psychotropic drugs Regression Analysis Schizophrenia Schizophrenia - therapy Schizophrenic Psychology Studies Substance abuse treatment Time Factors |
| title | Insight and psychopathology in never-treated schizophrenia |
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