Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration

Encephalopathy may accompany acute or chronic renal failure, and the mechanisms responsible for neurological complications in patients with renal failure are poorly known. Considering that creatine kinase (CK) is important for brain energy homeostasis and is inhibited by free radicals, and that oxid...

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Veröffentlicht in:	Neuroscience letters 2008-03, Vol.434 (1), p.139-143
Hauptverfasser:	Di-Pietro, Priscila B., Dias, Márcia L., Scaini, Giselli, Burigo, Márcio, Constantino, Larissa, Machado, Roberta A., Dal-Pizzol, Felipe, Streck, Emilio L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Acetylcysteine - therapeutic use Animals Antioxidants - pharmacology Antioxidants - therapeutic use Biological and medical sciences Brain - drug effects Brain - enzymology Brain - physiopathology Brain Diseases, Metabolic - drug therapy Brain Diseases, Metabolic - enzymology Brain Diseases, Metabolic - physiopathology Creatine kinase Creatine Kinase - antagonists & inhibitors Creatine Kinase - metabolism Deferoxamine Deferoxamine - pharmacology Deferoxamine - therapeutic use Down-Regulation - drug effects Down-Regulation - physiology Fundamental and applied biological sciences. Psychology Ischemia - complications Kidney Diseases - complications Male N-Acetylcysteine Nerve Degeneration - drug therapy Nerve Degeneration - enzymology Nerve Degeneration - physiopathology Oxidative Stress - drug effects Oxidative Stress - physiology Rats Rats, Wistar Renal failure Subcellular Fractions Time Factors Treatment Outcome Uremia - drug therapy Uremia - enzymology Uremia - physiopathology Vertebrates: nervous system and sense organs
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