Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage

Extracellular ATP, an autocrine or paracrine intercellular transmitter, is known to induce apoptosis in macrophages. However, the precise signaling mechanisms of ATP-induced apoptosis remain to be elucidated. Here we showed that activation of p38 mitogen-activated protein kinase (MAPK) plays a criti...

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Veröffentlicht in:	The Journal of biological chemistry 2008-03, Vol.283 (12), p.7657-7665
Hauptverfasser:	Noguchi, Takuya, Ishii, Ken, Fukutomi, Hisashi, Naguro, Isao, Matsuzawa, Atsushi, Takeda, Kohsuke, Ichijo, Hidenori
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Animals Apoptosis - drug effects Apoptosis - physiology Enzyme Activation - drug effects Enzyme Activation - physiology Humans Macrophages - enzymology MAP Kinase Kinase Kinase 5 - genetics MAP Kinase Kinase Kinase 5 - metabolism MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Knockout NADPH Oxidase 2 NADPH Oxidases - genetics NADPH Oxidases - metabolism p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Reactive Oxygen Species - metabolism Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2X7
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