Soy protein and isoflavones influence adiposity and development of metabolic syndrome in the obese male ZDF rat
Background/Aims: Previously, we demonstrated that soy protein ameliorates the diabetic phenotype in several rodent models of obesity and metabolic syndrome (MS). This study was designed to further elucidate factors related to adiposity, glycemic control, and renal function in male Zucker Diabetic Fa...
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| Veröffentlicht in: | Annals of nutrition and metabolism 2007-01, Vol.51 (1), p.42-52 |
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| creator | Davis, Jeremy Higginbotham, Allan O’Connor, Timothy Moustaid-Moussa, Naima Tebbe, Adam Kim, Young-Cheul Cho, Kae Won Shay, Neil Adler, Stuart Peterson, Richard Banz, William |
| description | Background/Aims: Previously, we demonstrated that soy protein ameliorates the diabetic phenotype in several rodent models of obesity and metabolic syndrome (MS). This study was designed to further elucidate factors related to adiposity, glycemic control, and renal function in male Zucker Diabetic Fatty (ZDF/Lepr(fa)) rats. Methods: Animals were randomly assigned to one of four diets: control, casein (C); low isoflavone (LIS) soy protein; high isoflavone (HIS) soy protein, or casein + rosiglitazone (CR) for 11 weeks. At sacrifice, physiological, biochemical, and molecular parameters were determined. Results: Body weight and total adiposity were higher in LIS and CR diet groups despite lower food intake. Additionally, these animals exhibited differential regulation of adipose-specific proteins (PPAR-gamma and GLUT4) and enzyme activity (FAS and GPDH). HIS-fed animals had reduced total and liver adiposity. Glycemic control was prolonged in both soy-based and rosiglitazone (RGZ) groups. Renal dysfunction was significantly reduced in soy-fed and RGZ-treated rodents as demonstrated by lower levels of proteinuria and dilated tubules with proteinaceous casts. Conclusion: Collectively, these data provide evidence that soy protein with low or high isoflavone content may have therapeutic significance in reducing severity of diabetes, MS, and renal disease as demonstrated in this preclinical model. |
| doi_str_mv | 10.1159/000100820 |
| format | Article |
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This study was designed to further elucidate factors related to adiposity, glycemic control, and renal function in male Zucker Diabetic Fatty (ZDF/Lepr(fa)) rats. Methods: Animals were randomly assigned to one of four diets: control, casein (C); low isoflavone (LIS) soy protein; high isoflavone (HIS) soy protein, or casein + rosiglitazone (CR) for 11 weeks. At sacrifice, physiological, biochemical, and molecular parameters were determined. Results: Body weight and total adiposity were higher in LIS and CR diet groups despite lower food intake. Additionally, these animals exhibited differential regulation of adipose-specific proteins (PPAR-gamma and GLUT4) and enzyme activity (FAS and GPDH). HIS-fed animals had reduced total and liver adiposity. Glycemic control was prolonged in both soy-based and rosiglitazone (RGZ) groups. Renal dysfunction was significantly reduced in soy-fed and RGZ-treated rodents as demonstrated by lower levels of proteinuria and dilated tubules with proteinaceous casts. Conclusion: Collectively, these data provide evidence that soy protein with low or high isoflavone content may have therapeutic significance in reducing severity of diabetes, MS, and renal disease as demonstrated in this preclinical model.</description><identifier>ISSN: 0250-6807</identifier><identifier>EISSN: 1421-9697</identifier><identifier>DOI: 10.1159/000100820</identifier><identifier>PMID: 17356265</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>adipocytes ; adipose tissue ; Adiposity - drug effects ; animal disease models ; Animals ; Blood Glucose - drug effects ; Body fat ; Body weight ; Caseins - pharmacology ; Diabetes ; diabetes mellitus ; Enzymatic activity ; glycemic control ; Hypoglycemic Agents - pharmacology ; isoflavones ; Isoflavones - pharmacology ; Kidney Diseases - prevention & control ; Kidneys ; lipogenesis ; Liver - drug effects ; Male ; males ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - diet therapy ; Metabolic Syndrome - etiology ; Milk Proteins - pharmacology ; Nutrition ; nutritional intervention ; Obesity ; Obesity - complications ; Original Paper ; overweight ; Phytochemicals ; Proteins ; Proteinuria - prevention & control ; Rats ; Rats, Inbred Strains ; Renal function ; Rodents ; Soy products ; soy protein ; Soybean Proteins - administration & dosage ; Thiazolidinediones - pharmacology ; Zucker Diabettic fatty rats</subject><ispartof>Annals of nutrition and metabolism, 2007-01, Vol.51 (1), p.42-52</ispartof><rights>2007 S. Karger AG</rights><rights>2007 S. Karger AG, Basel</rights><rights>Copyright 2007 S. Karger AG, Basel.</rights><rights>Copyright (c) 2007 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-cb8fed729ab2d069c39a6801ef0b2a6b3399f16c7aa6d79ed1d1c244a87567083</citedby><cites>FETCH-LOGICAL-c443t-cb8fed729ab2d069c39a6801ef0b2a6b3399f16c7aa6d79ed1d1c244a87567083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/48507640$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/48507640$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2422,27903,27904,57996,58229</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17356265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davis, Jeremy</creatorcontrib><creatorcontrib>Higginbotham, Allan</creatorcontrib><creatorcontrib>O’Connor, Timothy</creatorcontrib><creatorcontrib>Moustaid-Moussa, Naima</creatorcontrib><creatorcontrib>Tebbe, Adam</creatorcontrib><creatorcontrib>Kim, Young-Cheul</creatorcontrib><creatorcontrib>Cho, Kae Won</creatorcontrib><creatorcontrib>Shay, Neil</creatorcontrib><creatorcontrib>Adler, Stuart</creatorcontrib><creatorcontrib>Peterson, Richard</creatorcontrib><creatorcontrib>Banz, William</creatorcontrib><title>Soy protein and isoflavones influence adiposity and development of metabolic syndrome in the obese male ZDF rat</title><title>Annals of nutrition and metabolism</title><addtitle>Ann Nutr Metab</addtitle><description>Background/Aims: Previously, we demonstrated that soy protein ameliorates the diabetic phenotype in several rodent models of obesity and metabolic syndrome (MS). This study was designed to further elucidate factors related to adiposity, glycemic control, and renal function in male Zucker Diabetic Fatty (ZDF/Lepr(fa)) rats. Methods: Animals were randomly assigned to one of four diets: control, casein (C); low isoflavone (LIS) soy protein; high isoflavone (HIS) soy protein, or casein + rosiglitazone (CR) for 11 weeks. At sacrifice, physiological, biochemical, and molecular parameters were determined. Results: Body weight and total adiposity were higher in LIS and CR diet groups despite lower food intake. Additionally, these animals exhibited differential regulation of adipose-specific proteins (PPAR-gamma and GLUT4) and enzyme activity (FAS and GPDH). HIS-fed animals had reduced total and liver adiposity. Glycemic control was prolonged in both soy-based and rosiglitazone (RGZ) groups. Renal dysfunction was significantly reduced in soy-fed and RGZ-treated rodents as demonstrated by lower levels of proteinuria and dilated tubules with proteinaceous casts. Conclusion: Collectively, these data provide evidence that soy protein with low or high isoflavone content may have therapeutic significance in reducing severity of diabetes, MS, and renal disease as demonstrated in this preclinical model.</description><subject>adipocytes</subject><subject>adipose tissue</subject><subject>Adiposity - drug effects</subject><subject>animal disease models</subject><subject>Animals</subject><subject>Blood Glucose - drug effects</subject><subject>Body fat</subject><subject>Body weight</subject><subject>Caseins - pharmacology</subject><subject>Diabetes</subject><subject>diabetes mellitus</subject><subject>Enzymatic activity</subject><subject>glycemic control</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>isoflavones</subject><subject>Isoflavones - pharmacology</subject><subject>Kidney Diseases - prevention & control</subject><subject>Kidneys</subject><subject>lipogenesis</subject><subject>Liver - drug effects</subject><subject>Male</subject><subject>males</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - diet therapy</subject><subject>Metabolic Syndrome - etiology</subject><subject>Milk Proteins - pharmacology</subject><subject>Nutrition</subject><subject>nutritional intervention</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Original Paper</subject><subject>overweight</subject><subject>Phytochemicals</subject><subject>Proteins</subject><subject>Proteinuria - prevention & control</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Renal function</subject><subject>Rodents</subject><subject>Soy products</subject><subject>soy protein</subject><subject>Soybean Proteins - administration & dosage</subject><subject>Thiazolidinediones - pharmacology</subject><subject>Zucker Diabettic fatty rats</subject><issn>0250-6807</issn><issn>1421-9697</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0U1v1DAQBmALgei2cODOh8UBqYfA2E78cawKhUqVOJReuFiOPSlZknixk0r773HJiiJOPrzPjGY8hLxg8J6xxnwAAAagOTwiG1ZzVhlp1GOyAd5AJTWoI3Kc87YoruvmKTliSjSSy2ZD4nXc012KM_YTdVOgfY7d4O7ihJn2UzcsOHmkLvS7mPt5_8cEvMMh7kacZho7OuLs2jj0nub9FFIcsVTS-QfS2GJGOroB6fePFzS5-Rl50rkh4_PDe0JuLj59O_9SXX39fHl-dlX5uhZz5VvdYVDcuJYHkMYL48oiDDtouZOtEMZ0THrlnAzKYGCBeV7XTqtGKtDihLxb-5bdfi2YZzv22eMwuAnjkq2CGjTTqsC3_8FtXNJUZrNccAZGQFPQ6Yp8ijkn7Owu9aNLe8vA3p_A_j1Bsa8PDZd2xPAgD39ewMsV_HTpFtM_rQ71r9Z4m-f4kNa6ASXr-_zNmncuWneb-mxvrjkwAaB0GViJ37ZdnJo</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Davis, Jeremy</creator><creator>Higginbotham, Allan</creator><creator>O’Connor, Timothy</creator><creator>Moustaid-Moussa, Naima</creator><creator>Tebbe, Adam</creator><creator>Kim, Young-Cheul</creator><creator>Cho, Kae Won</creator><creator>Shay, Neil</creator><creator>Adler, Stuart</creator><creator>Peterson, Richard</creator><creator>Banz, William</creator><general>S. 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drug effects</topic><topic>animal disease models</topic><topic>Animals</topic><topic>Blood Glucose - drug effects</topic><topic>Body fat</topic><topic>Body weight</topic><topic>Caseins - pharmacology</topic><topic>Diabetes</topic><topic>diabetes mellitus</topic><topic>Enzymatic activity</topic><topic>glycemic control</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>isoflavones</topic><topic>Isoflavones - pharmacology</topic><topic>Kidney Diseases - prevention & control</topic><topic>Kidneys</topic><topic>lipogenesis</topic><topic>Liver - drug effects</topic><topic>Male</topic><topic>males</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - diet therapy</topic><topic>Metabolic Syndrome - etiology</topic><topic>Milk Proteins - pharmacology</topic><topic>Nutrition</topic><topic>nutritional intervention</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Original Paper</topic><topic>overweight</topic><topic>Phytochemicals</topic><topic>Proteins</topic><topic>Proteinuria - prevention & control</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Renal function</topic><topic>Rodents</topic><topic>Soy products</topic><topic>soy protein</topic><topic>Soybean Proteins - administration & dosage</topic><topic>Thiazolidinediones - pharmacology</topic><topic>Zucker Diabettic fatty rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davis, Jeremy</creatorcontrib><creatorcontrib>Higginbotham, Allan</creatorcontrib><creatorcontrib>O’Connor, Timothy</creatorcontrib><creatorcontrib>Moustaid-Moussa, Naima</creatorcontrib><creatorcontrib>Tebbe, Adam</creatorcontrib><creatorcontrib>Kim, Young-Cheul</creatorcontrib><creatorcontrib>Cho, Kae Won</creatorcontrib><creatorcontrib>Shay, Neil</creatorcontrib><creatorcontrib>Adler, Stuart</creatorcontrib><creatorcontrib>Peterson, Richard</creatorcontrib><creatorcontrib>Banz, William</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of nutrition and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davis, Jeremy</au><au>Higginbotham, Allan</au><au>O’Connor, Timothy</au><au>Moustaid-Moussa, Naima</au><au>Tebbe, Adam</au><au>Kim, Young-Cheul</au><au>Cho, Kae Won</au><au>Shay, Neil</au><au>Adler, Stuart</au><au>Peterson, Richard</au><au>Banz, William</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soy protein and isoflavones influence adiposity and development of metabolic syndrome in the obese male ZDF rat</atitle><jtitle>Annals of nutrition and metabolism</jtitle><addtitle>Ann Nutr Metab</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>51</volume><issue>1</issue><spage>42</spage><epage>52</epage><pages>42-52</pages><issn>0250-6807</issn><eissn>1421-9697</eissn><abstract>Background/Aims: Previously, we demonstrated that soy protein ameliorates the diabetic phenotype in several rodent models of obesity and metabolic syndrome (MS). This study was designed to further elucidate factors related to adiposity, glycemic control, and renal function in male Zucker Diabetic Fatty (ZDF/Lepr(fa)) rats. Methods: Animals were randomly assigned to one of four diets: control, casein (C); low isoflavone (LIS) soy protein; high isoflavone (HIS) soy protein, or casein + rosiglitazone (CR) for 11 weeks. At sacrifice, physiological, biochemical, and molecular parameters were determined. Results: Body weight and total adiposity were higher in LIS and CR diet groups despite lower food intake. Additionally, these animals exhibited differential regulation of adipose-specific proteins (PPAR-gamma and GLUT4) and enzyme activity (FAS and GPDH). HIS-fed animals had reduced total and liver adiposity. Glycemic control was prolonged in both soy-based and rosiglitazone (RGZ) groups. Renal dysfunction was significantly reduced in soy-fed and RGZ-treated rodents as demonstrated by lower levels of proteinuria and dilated tubules with proteinaceous casts. Conclusion: Collectively, these data provide evidence that soy protein with low or high isoflavone content may have therapeutic significance in reducing severity of diabetes, MS, and renal disease as demonstrated in this preclinical model.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>17356265</pmid><doi>10.1159/000100820</doi><tpages>11</tpages></addata></record> |
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| subjects | adipocytes adipose tissue Adiposity - drug effects animal disease models Animals Blood Glucose - drug effects Body fat Body weight Caseins - pharmacology Diabetes diabetes mellitus Enzymatic activity glycemic control Hypoglycemic Agents - pharmacology isoflavones Isoflavones - pharmacology Kidney Diseases - prevention & control Kidneys lipogenesis Liver - drug effects Male males Metabolic disorders Metabolic syndrome Metabolic Syndrome - diet therapy Metabolic Syndrome - etiology Milk Proteins - pharmacology Nutrition nutritional intervention Obesity Obesity - complications Original Paper overweight Phytochemicals Proteins Proteinuria - prevention & control Rats Rats, Inbred Strains Renal function Rodents Soy products soy protein Soybean Proteins - administration & dosage Thiazolidinediones - pharmacology Zucker Diabettic fatty rats |
| title | Soy protein and isoflavones influence adiposity and development of metabolic syndrome in the obese male ZDF rat |
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