The establishment of a rat model of chronic pulmonary infection due to Pseudomonas aeruginosa
To establish a rat model of chronic pulmonary infection by inoculating two different Pseudomonas aeruginosa embedded in minute seaweed alginate beads made by an ejection set with an acuminata hole to Sprague-Dawley rats. To evaluate the animal model with bacteriology and pathology values. (1) 300 he...
Gespeichert in:
| Veröffentlicht in: | Zhong hua yi xue za zhi 2008-01, Vol.88 (1), p.46-50 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | chi |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 50 |
|---|---|
| container_issue | 1 |
| container_start_page | 46 |
| container_title | Zhong hua yi xue za zhi |
| container_volume | 88 |
| creator | Wang, Wei-Fang Fang, Xiang-Qun Liu, You-Ning |
| description | To establish a rat model of chronic pulmonary infection by inoculating two different Pseudomonas aeruginosa embedded in minute seaweed alginate beads made by an ejection set with an acuminata hole to Sprague-Dawley rats. To evaluate the animal model with bacteriology and pathology values.
(1) 300 healthy, clean Sprague-Dawley rats were divided into 3 groups randomly: the wide-type Pseudomonas aeruginosa group (PAO(1) group), the mutant type Pseudomonas aeruginosa group (PAO-JP2 group) and the control group. (2) Two different Pseudomonas aeruginosa were embedded in minute seaweed alginate beads by an ejection set with an acuminata hole. Then the beads were inoculated into the rats' lung through tracheal intubation. The bacteria numbers in lung and pathology scores were measured 3, 7, 14, 28 days after infection.
(1) The bacteriology values: No bacterium were detected in the control group. PAO(1) and PAO-JP2 were detected from rats of PAO1 and PAO-JP2 infected groups respectively. Bacterial number was higher th |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_70408168</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70408168</sourcerecordid><originalsourceid>FETCH-LOGICAL-p124t-1fb646bf7a26464a6652fb300adaaf1712aba618891f0c284a654dd510864bf13</originalsourceid><addsrcrecordid>eNo1kE1LxDAYhHNQ3GXdvyA5eSvkq2l6lMUvWNDDepTypklsoE1qkxz893ZxPQ3DPAzMXKEt4Y2smGjpBu1T8pqIhreMMHqDNlRxIbkiW_R5Giy2KYMefRomGzKODgNeIOMpGjuebT8sMfgez2WcYoDlB_vgbJ99DNgUi3PE78kWE89pwmCX8uVDTHCLrh2Mye4vukMfT4-nw0t1fHt-PTwcq5kykSvqtBRSuwbYqgKkrJnTnBAwAI42lIEGSZVqqSM9UytRC2NqSpQU2lG-Q_d_vfMSv8s6p5t86u04QrCxpK4hgigq1QreXcCiJ2u6efHTuqf7P4T_AjEkXRY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70408168</pqid></control><display><type>article</type><title>The establishment of a rat model of chronic pulmonary infection due to Pseudomonas aeruginosa</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Wang, Wei-Fang ; Fang, Xiang-Qun ; Liu, You-Ning</creator><creatorcontrib>Wang, Wei-Fang ; Fang, Xiang-Qun ; Liu, You-Ning</creatorcontrib><description>To establish a rat model of chronic pulmonary infection by inoculating two different Pseudomonas aeruginosa embedded in minute seaweed alginate beads made by an ejection set with an acuminata hole to Sprague-Dawley rats. To evaluate the animal model with bacteriology and pathology values.
(1) 300 healthy, clean Sprague-Dawley rats were divided into 3 groups randomly: the wide-type Pseudomonas aeruginosa group (PAO(1) group), the mutant type Pseudomonas aeruginosa group (PAO-JP2 group) and the control group. (2) Two different Pseudomonas aeruginosa were embedded in minute seaweed alginate beads by an ejection set with an acuminata hole. Then the beads were inoculated into the rats' lung through tracheal intubation. The bacteria numbers in lung and pathology scores were measured 3, 7, 14, 28 days after infection.
(1) The bacteriology values: No bacterium were detected in the control group. PAO(1) and PAO-JP2 were detected from rats of PAO1 and PAO-JP2 infected groups respectively. Bacterial number was higher th</description><identifier>ISSN: 0376-2491</identifier><identifier>PMID: 18346380</identifier><language>chi</language><publisher>China</publisher><subject>Animals ; Chronic Disease ; Disease Models, Animal ; Female ; Male ; Pneumonia, Bacterial - microbiology ; Pseudomonas aeruginosa - growth & development ; Pseudomonas Infections - microbiology ; Random Allocation ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Zhong hua yi xue za zhi, 2008-01, Vol.88 (1), p.46-50</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18346380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Wei-Fang</creatorcontrib><creatorcontrib>Fang, Xiang-Qun</creatorcontrib><creatorcontrib>Liu, You-Ning</creatorcontrib><title>The establishment of a rat model of chronic pulmonary infection due to Pseudomonas aeruginosa</title><title>Zhong hua yi xue za zhi</title><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><description>To establish a rat model of chronic pulmonary infection by inoculating two different Pseudomonas aeruginosa embedded in minute seaweed alginate beads made by an ejection set with an acuminata hole to Sprague-Dawley rats. To evaluate the animal model with bacteriology and pathology values.
(1) 300 healthy, clean Sprague-Dawley rats were divided into 3 groups randomly: the wide-type Pseudomonas aeruginosa group (PAO(1) group), the mutant type Pseudomonas aeruginosa group (PAO-JP2 group) and the control group. (2) Two different Pseudomonas aeruginosa were embedded in minute seaweed alginate beads by an ejection set with an acuminata hole. Then the beads were inoculated into the rats' lung through tracheal intubation. The bacteria numbers in lung and pathology scores were measured 3, 7, 14, 28 days after infection.
(1) The bacteriology values: No bacterium were detected in the control group. PAO(1) and PAO-JP2 were detected from rats of PAO1 and PAO-JP2 infected groups respectively. Bacterial number was higher th</description><subject>Animals</subject><subject>Chronic Disease</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Male</subject><subject>Pneumonia, Bacterial - microbiology</subject><subject>Pseudomonas aeruginosa - growth & development</subject><subject>Pseudomonas Infections - microbiology</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0376-2491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LxDAYhHNQ3GXdvyA5eSvkq2l6lMUvWNDDepTypklsoE1qkxz893ZxPQ3DPAzMXKEt4Y2smGjpBu1T8pqIhreMMHqDNlRxIbkiW_R5Giy2KYMefRomGzKODgNeIOMpGjuebT8sMfgez2WcYoDlB_vgbJ99DNgUi3PE78kWE89pwmCX8uVDTHCLrh2Mye4vukMfT4-nw0t1fHt-PTwcq5kykSvqtBRSuwbYqgKkrJnTnBAwAI42lIEGSZVqqSM9UytRC2NqSpQU2lG-Q_d_vfMSv8s6p5t86u04QrCxpK4hgigq1QreXcCiJ2u6efHTuqf7P4T_AjEkXRY</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Wang, Wei-Fang</creator><creator>Fang, Xiang-Qun</creator><creator>Liu, You-Ning</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>The establishment of a rat model of chronic pulmonary infection due to Pseudomonas aeruginosa</title><author>Wang, Wei-Fang ; Fang, Xiang-Qun ; Liu, You-Ning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-1fb646bf7a26464a6652fb300adaaf1712aba618891f0c284a654dd510864bf13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Chronic Disease</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Male</topic><topic>Pneumonia, Bacterial - microbiology</topic><topic>Pseudomonas aeruginosa - growth & development</topic><topic>Pseudomonas Infections - microbiology</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Wei-Fang</creatorcontrib><creatorcontrib>Fang, Xiang-Qun</creatorcontrib><creatorcontrib>Liu, You-Ning</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhong hua yi xue za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Wei-Fang</au><au>Fang, Xiang-Qun</au><au>Liu, You-Ning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The establishment of a rat model of chronic pulmonary infection due to Pseudomonas aeruginosa</atitle><jtitle>Zhong hua yi xue za zhi</jtitle><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>88</volume><issue>1</issue><spage>46</spage><epage>50</epage><pages>46-50</pages><issn>0376-2491</issn><abstract>To establish a rat model of chronic pulmonary infection by inoculating two different Pseudomonas aeruginosa embedded in minute seaweed alginate beads made by an ejection set with an acuminata hole to Sprague-Dawley rats. To evaluate the animal model with bacteriology and pathology values.
(1) 300 healthy, clean Sprague-Dawley rats were divided into 3 groups randomly: the wide-type Pseudomonas aeruginosa group (PAO(1) group), the mutant type Pseudomonas aeruginosa group (PAO-JP2 group) and the control group. (2) Two different Pseudomonas aeruginosa were embedded in minute seaweed alginate beads by an ejection set with an acuminata hole. Then the beads were inoculated into the rats' lung through tracheal intubation. The bacteria numbers in lung and pathology scores were measured 3, 7, 14, 28 days after infection.
(1) The bacteriology values: No bacterium were detected in the control group. PAO(1) and PAO-JP2 were detected from rats of PAO1 and PAO-JP2 infected groups respectively. Bacterial number was higher th</abstract><cop>China</cop><pmid>18346380</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0376-2491 |
| ispartof | Zhong hua yi xue za zhi, 2008-01, Vol.88 (1), p.46-50 |
| issn | 0376-2491 |
| language | chi |
| recordid | cdi_proquest_miscellaneous_70408168 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Chronic Disease Disease Models, Animal Female Male Pneumonia, Bacterial - microbiology Pseudomonas aeruginosa - growth & development Pseudomonas Infections - microbiology Random Allocation Rats Rats, Sprague-Dawley |
| title | The establishment of a rat model of chronic pulmonary infection due to Pseudomonas aeruginosa |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T03%3A31%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20establishment%20of%20a%20rat%20model%20of%20chronic%20pulmonary%20infection%20due%20to%20Pseudomonas%20aeruginosa&rft.jtitle=Zhong%20hua%20yi%20xue%20za%20zhi&rft.au=Wang,%20Wei-Fang&rft.date=2008-01-01&rft.volume=88&rft.issue=1&rft.spage=46&rft.epage=50&rft.pages=46-50&rft.issn=0376-2491&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E70408168%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70408168&rft_id=info:pmid/18346380&rfr_iscdi=true |