Osteopontin, a Protein with Cytokine-like Properties, is Associated with Inflammation in Crohn's Disease

In Crohn's disease (CD) mucosal T-cells produce increased interferon-γ (IFN-γ) and tumour necrosis factor-α (TNF-α) levels and TNF-α antibody treatment [Infliximab (Ifx)] is effective. Osteopontin (OPN), a glycoprotein stimulating activated T-lymphocytes, may be involved in the disturbed immune...

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