Vaginal allergic response in women with vulvovaginal candidiasis
Abstract Objective : To determine the concentration of certain cytokines and immunoglobulin (Ig) E in the vaginal lavage fluid (VLF) of women with vulvovaginal candidiasis (VVC). Method : Cytokin and IgE concentrations were measured in the VLF of women with VVC; women free of any genital infections...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 2008-04, Vol.101 (1), p.27-30 |
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| container_title | International journal of gynecology and obstetrics |
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| creator | Fan, S.R Liao, Q.P Liu, X.P Liu, Z.H Zhang, D |
| description | Abstract Objective : To determine the concentration of certain cytokines and immunoglobulin (Ig) E in the vaginal lavage fluid (VLF) of women with vulvovaginal candidiasis (VVC). Method : Cytokin and IgE concentrations were measured in the VLF of women with VVC; women free of any genital infections acted as controls. Result : The VLF concentrations of interleukin (IL)-2, IL-8, and interferon (INF)-γ were higher among women with VVC than in the control group; women with severe VVC had a higher VLF concentration of IL-4 than those with mild to moderate VVC; women with cured VVC had a higher VLF concentration of IL-13 than did controls; and women with VVC or cured VVC had a higher VLF concentration of IgE than did controls ( P < 0.05 for all). Conclusion : Both helper T cells type 1 and innate response cytokines were shown to play a dominant role in the pathogenesis of VVC. This allergic vaginal response in women with VVC suggests that the form of treatment for VVC should be reconsidered. |
| doi_str_mv | 10.1016/j.ijgo.2007.08.024 |
| format | Article |
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Method : Cytokin and IgE concentrations were measured in the VLF of women with VVC; women free of any genital infections acted as controls. Result : The VLF concentrations of interleukin (IL)-2, IL-8, and interferon (INF)-γ were higher among women with VVC than in the control group; women with severe VVC had a higher VLF concentration of IL-4 than those with mild to moderate VVC; women with cured VVC had a higher VLF concentration of IL-13 than did controls; and women with VVC or cured VVC had a higher VLF concentration of IgE than did controls ( P < 0.05 for all). Conclusion : Both helper T cells type 1 and innate response cytokines were shown to play a dominant role in the pathogenesis of VVC. This allergic vaginal response in women with VVC suggests that the form of treatment for VVC should be reconsidered.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1016/j.ijgo.2007.08.024</identifier><identifier>PMID: 18280478</identifier><identifier>CODEN: IJGOAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Allergic response ; Biological and medical sciences ; Candidiasis, Vulvovaginal - immunology ; Candidiasis, Vulvovaginal - physiopathology ; Chemokines ; Cytokines ; Cytokines - analysis ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Immunoglobulin ; Immunoglobulin E - analysis ; Interferon-gamma - analysis ; Interleukin-13 - analysis ; Interleukin-2 - analysis ; Interleukin-4 - analysis ; Interleukin-8 - analysis ; Medical sciences ; Obstetrics and Gynecology ; Severity of Illness Index ; Vagina - chemistry ; Vaginal Douching ; Vulvovaginal candidiasis</subject><ispartof>International journal of gynecology and obstetrics, 2008-04, Vol.101 (1), p.27-30</ispartof><rights>International Federation of Gynecology and Obstetrics</rights><rights>2008 International Federation of Gynecology and Obstetrics</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4867-1b3f636c7097119f7bdd018f28ddd6f9bcd58ae1a7ffaf21db374531ca1044ea3</citedby><cites>FETCH-LOGICAL-c4867-1b3f636c7097119f7bdd018f28ddd6f9bcd58ae1a7ffaf21db374531ca1044ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.ijgo.2007.08.024$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.ijgo.2007.08.024$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20214987$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18280478$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fan, S.R</creatorcontrib><creatorcontrib>Liao, Q.P</creatorcontrib><creatorcontrib>Liu, X.P</creatorcontrib><creatorcontrib>Liu, Z.H</creatorcontrib><creatorcontrib>Zhang, D</creatorcontrib><title>Vaginal allergic response in women with vulvovaginal candidiasis</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Abstract Objective : To determine the concentration of certain cytokines and immunoglobulin (Ig) E in the vaginal lavage fluid (VLF) of women with vulvovaginal candidiasis (VVC). Method : Cytokin and IgE concentrations were measured in the VLF of women with VVC; women free of any genital infections acted as controls. Result : The VLF concentrations of interleukin (IL)-2, IL-8, and interferon (INF)-γ were higher among women with VVC than in the control group; women with severe VVC had a higher VLF concentration of IL-4 than those with mild to moderate VVC; women with cured VVC had a higher VLF concentration of IL-13 than did controls; and women with VVC or cured VVC had a higher VLF concentration of IgE than did controls ( P < 0.05 for all). Conclusion : Both helper T cells type 1 and innate response cytokines were shown to play a dominant role in the pathogenesis of VVC. This allergic vaginal response in women with VVC suggests that the form of treatment for VVC should be reconsidered.</description><subject>Allergic response</subject><subject>Biological and medical sciences</subject><subject>Candidiasis, Vulvovaginal - immunology</subject><subject>Candidiasis, Vulvovaginal - physiopathology</subject><subject>Chemokines</subject><subject>Cytokines</subject><subject>Cytokines - analysis</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunoglobulin</subject><subject>Immunoglobulin E - analysis</subject><subject>Interferon-gamma - analysis</subject><subject>Interleukin-13 - analysis</subject><subject>Interleukin-2 - analysis</subject><subject>Interleukin-4 - analysis</subject><subject>Interleukin-8 - analysis</subject><subject>Medical sciences</subject><subject>Obstetrics and Gynecology</subject><subject>Severity of Illness Index</subject><subject>Vagina - chemistry</subject><subject>Vaginal Douching</subject><subject>Vulvovaginal candidiasis</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhi0EotvCH-CAcoFbwtjxxo6EEKiCUlSpBz6ulmOPFwdvsrU3W-2_r6ONQOKAuNiX5x3PPB5CXlCoKNDmTV_5fjNWDEBUICtg_BFZUSnasuaifUxWAAxKwVp2Rs5T6gGACkqfkjMqmQQu5Iq8_6E3ftCh0CFg3HhTREy7cUhY-KG4H7eYT7__WRymcBgPC2z0YL31Ovn0jDxxOiR8vtwX5Punj98uP5c3t1fXlx9uSsNlI0ra1a6pGyOgzS20TnTWApWOSWtt49rO2LXUSLVwTjtGbVcLvq6p0RQ4R11fkNenurs43k2Y9mrrk8EQ9IDjlJQADs0aZAbZCTRxTCmiU7votzoeFQU1e1O9mr2p2ZsCqbK3HHq5VJ-6Ldo_kUVUBl4tgE5GBxf1YHz6zTFglLdSZK45cfc-4PE_nlbXX65u2Rx8ewpilnjwGFUyHgeD1kc0e2VH_-8B3v0VN8EPPrf6C4-Y-nGK-eOSoioxBerrvBrzZoAAaCij9QPHxLHh</recordid><startdate>200804</startdate><enddate>200804</enddate><creator>Fan, S.R</creator><creator>Liao, Q.P</creator><creator>Liu, X.P</creator><creator>Liu, Z.H</creator><creator>Zhang, D</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200804</creationdate><title>Vaginal allergic response in women with vulvovaginal candidiasis</title><author>Fan, S.R ; Liao, Q.P ; Liu, X.P ; Liu, Z.H ; Zhang, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4867-1b3f636c7097119f7bdd018f28ddd6f9bcd58ae1a7ffaf21db374531ca1044ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Allergic response</topic><topic>Biological and medical sciences</topic><topic>Candidiasis, Vulvovaginal - immunology</topic><topic>Candidiasis, Vulvovaginal - physiopathology</topic><topic>Chemokines</topic><topic>Cytokines</topic><topic>Cytokines - analysis</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunoglobulin</topic><topic>Immunoglobulin E - analysis</topic><topic>Interferon-gamma - analysis</topic><topic>Interleukin-13 - analysis</topic><topic>Interleukin-2 - analysis</topic><topic>Interleukin-4 - analysis</topic><topic>Interleukin-8 - analysis</topic><topic>Medical sciences</topic><topic>Obstetrics and Gynecology</topic><topic>Severity of Illness Index</topic><topic>Vagina - chemistry</topic><topic>Vaginal Douching</topic><topic>Vulvovaginal candidiasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fan, S.R</creatorcontrib><creatorcontrib>Liao, Q.P</creatorcontrib><creatorcontrib>Liu, X.P</creatorcontrib><creatorcontrib>Liu, Z.H</creatorcontrib><creatorcontrib>Zhang, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fan, S.R</au><au>Liao, Q.P</au><au>Liu, X.P</au><au>Liu, Z.H</au><au>Zhang, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vaginal allergic response in women with vulvovaginal candidiasis</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2008-04</date><risdate>2008</risdate><volume>101</volume><issue>1</issue><spage>27</spage><epage>30</epage><pages>27-30</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><coden>IJGOAL</coden><abstract>Abstract Objective : To determine the concentration of certain cytokines and immunoglobulin (Ig) E in the vaginal lavage fluid (VLF) of women with vulvovaginal candidiasis (VVC). Method : Cytokin and IgE concentrations were measured in the VLF of women with VVC; women free of any genital infections acted as controls. Result : The VLF concentrations of interleukin (IL)-2, IL-8, and interferon (INF)-γ were higher among women with VVC than in the control group; women with severe VVC had a higher VLF concentration of IL-4 than those with mild to moderate VVC; women with cured VVC had a higher VLF concentration of IL-13 than did controls; and women with VVC or cured VVC had a higher VLF concentration of IgE than did controls ( P < 0.05 for all). Conclusion : Both helper T cells type 1 and innate response cytokines were shown to play a dominant role in the pathogenesis of VVC. This allergic vaginal response in women with VVC suggests that the form of treatment for VVC should be reconsidered.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18280478</pmid><doi>10.1016/j.ijgo.2007.08.024</doi><tpages>4</tpages></addata></record> |
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| ispartof | International journal of gynecology and obstetrics, 2008-04, Vol.101 (1), p.27-30 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Allergic response Biological and medical sciences Candidiasis, Vulvovaginal - immunology Candidiasis, Vulvovaginal - physiopathology Chemokines Cytokines Cytokines - analysis Female Gynecology. Andrology. Obstetrics Humans Immunoglobulin Immunoglobulin E - analysis Interferon-gamma - analysis Interleukin-13 - analysis Interleukin-2 - analysis Interleukin-4 - analysis Interleukin-8 - analysis Medical sciences Obstetrics and Gynecology Severity of Illness Index Vagina - chemistry Vaginal Douching Vulvovaginal candidiasis |
| title | Vaginal allergic response in women with vulvovaginal candidiasis |
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