Association of Morbid Obesity With FTO and INSIG2 Allelic Variants
OBJECTIVE To determine whether 2 single nucleotide polymorphisms (SNPs) in the obesity genes the fat mass and obesity associated gene (FTO) and the insulin induced gene 2 (INSIG2) are associated with class III, or morbid, obesity in patients undergoing bariatric weight loss operations. DESIGN Retros...
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| Veröffentlicht in: | Archives of surgery (Chicago. 1960) 2008-03, Vol.143 (3), p.235-240 |
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| creator | Chu, Xin Erdman, Robert Susek, Meghan Gerst, Heather Derr, Kimberly Al-Agha, Mouna Wood, G. Craig Hartman, Christina Yeager, Stephanie Blosky, Mary Ann Krum, Wanda Stewart, Walter F Carey, David Benotti, Peter Still, Christopher D Gerhard, Glenn S |
| description | OBJECTIVE To determine whether 2 single nucleotide polymorphisms (SNPs) in the obesity genes the fat mass and obesity associated gene (FTO) and the insulin induced gene 2 (INSIG2) are associated with class III, or morbid, obesity in patients undergoing bariatric weight loss operations. DESIGN Retrospective analysis of genotype and clinical data. SETTING Large rural tertiary care health system. PATIENTS A total of 707 adult patients with a body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) of at least 40 undergoing open or laparoscopic Roux-en-Y gastric bypass operations for morbid obesity or its comorbid medical problems at Geisinger Medical Center, Danville, Pennsylvania. RESULTS The mean BMI in the predominantly white female cohort was 51.2. Approximately 21% of patients were homozygous for the FTO obesity SNP variant, 13% were homozygous for the INSIG2 obesity SNP variant, and 3.4% were homozygous for both. Mean BMIs in the groups homozygous for each of these genes were not significantly different from nonhomozygotes. However, FTO/INSIG2 double homozygotes and homozygote/heterozygote pairs had significantly higher BMIs than the other groups. CONCLUSION Increased BMI in morbid obesity is associated with a combination of FTO and INSIG2 SNPs.Arch Surg. 2008;143(3):235-240--> |
| doi_str_mv | 10.1001/archsurg.2007.77 |
| format | Article |
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Craig ; Hartman, Christina ; Yeager, Stephanie ; Blosky, Mary Ann ; Krum, Wanda ; Stewart, Walter F ; Carey, David ; Benotti, Peter ; Still, Christopher D ; Gerhard, Glenn S</creator><creatorcontrib>Chu, Xin ; Erdman, Robert ; Susek, Meghan ; Gerst, Heather ; Derr, Kimberly ; Al-Agha, Mouna ; Wood, G. Craig ; Hartman, Christina ; Yeager, Stephanie ; Blosky, Mary Ann ; Krum, Wanda ; Stewart, Walter F ; Carey, David ; Benotti, Peter ; Still, Christopher D ; Gerhard, Glenn S</creatorcontrib><description>OBJECTIVE To determine whether 2 single nucleotide polymorphisms (SNPs) in the obesity genes the fat mass and obesity associated gene (FTO) and the insulin induced gene 2 (INSIG2) are associated with class III, or morbid, obesity in patients undergoing bariatric weight loss operations. DESIGN Retrospective analysis of genotype and clinical data. SETTING Large rural tertiary care health system. PATIENTS A total of 707 adult patients with a body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) of at least 40 undergoing open or laparoscopic Roux-en-Y gastric bypass operations for morbid obesity or its comorbid medical problems at Geisinger Medical Center, Danville, Pennsylvania. RESULTS The mean BMI in the predominantly white female cohort was 51.2. Approximately 21% of patients were homozygous for the FTO obesity SNP variant, 13% were homozygous for the INSIG2 obesity SNP variant, and 3.4% were homozygous for both. Mean BMIs in the groups homozygous for each of these genes were not significantly different from nonhomozygotes. However, FTO/INSIG2 double homozygotes and homozygote/heterozygote pairs had significantly higher BMIs than the other groups. CONCLUSION Increased BMI in morbid obesity is associated with a combination of FTO and INSIG2 SNPs.Arch Surg. 2008;143(3):235-240--></description><identifier>ISSN: 0004-0010</identifier><identifier>ISSN: 2168-6254</identifier><identifier>EISSN: 1538-3644</identifier><identifier>EISSN: 2168-6262</identifier><identifier>DOI: 10.1001/archsurg.2007.77</identifier><identifier>PMID: 18347269</identifier><identifier>CODEN: ARSUAX</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Adolescent ; Adult ; Aged ; Alleles ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Bariatric Surgery ; Biological and medical sciences ; Body fat ; Female ; General aspects ; Genes ; Genotype ; Humans ; Insulin ; Intracellular Signaling Peptides and Proteins - genetics ; Male ; Medical sciences ; Membrane Proteins - genetics ; Metabolic diseases ; Metabolism ; Middle Aged ; Obesity ; Obesity, Morbid - genetics ; Obesity, Morbid - surgery ; Polymorphism ; Polymorphism, Single Nucleotide ; Proteins - genetics ; Retrospective Studies ; Rural Population</subject><ispartof>Archives of surgery (Chicago. 1960), 2008-03, Vol.143 (3), p.235-240</ispartof><rights>2008 INIST-CNRS</rights><rights>Copyright American Medical Association Mar 2008</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a287t-bd9678e302d7683ba4de18270dfbf8d626a684f37be1ea0c8a8949899edf28263</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamasurgery/articlepdf/10.1001/archsurg.2007.77$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/archsurg.2007.77$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,314,776,780,3326,27903,27904,76236,76239</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20166527$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18347269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chu, Xin</creatorcontrib><creatorcontrib>Erdman, Robert</creatorcontrib><creatorcontrib>Susek, Meghan</creatorcontrib><creatorcontrib>Gerst, Heather</creatorcontrib><creatorcontrib>Derr, Kimberly</creatorcontrib><creatorcontrib>Al-Agha, Mouna</creatorcontrib><creatorcontrib>Wood, G. Craig</creatorcontrib><creatorcontrib>Hartman, Christina</creatorcontrib><creatorcontrib>Yeager, Stephanie</creatorcontrib><creatorcontrib>Blosky, Mary Ann</creatorcontrib><creatorcontrib>Krum, Wanda</creatorcontrib><creatorcontrib>Stewart, Walter F</creatorcontrib><creatorcontrib>Carey, David</creatorcontrib><creatorcontrib>Benotti, Peter</creatorcontrib><creatorcontrib>Still, Christopher D</creatorcontrib><creatorcontrib>Gerhard, Glenn S</creatorcontrib><title>Association of Morbid Obesity With FTO and INSIG2 Allelic Variants</title><title>Archives of surgery (Chicago. 1960)</title><addtitle>Arch Surg</addtitle><description>OBJECTIVE To determine whether 2 single nucleotide polymorphisms (SNPs) in the obesity genes the fat mass and obesity associated gene (FTO) and the insulin induced gene 2 (INSIG2) are associated with class III, or morbid, obesity in patients undergoing bariatric weight loss operations. DESIGN Retrospective analysis of genotype and clinical data. SETTING Large rural tertiary care health system. PATIENTS A total of 707 adult patients with a body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) of at least 40 undergoing open or laparoscopic Roux-en-Y gastric bypass operations for morbid obesity or its comorbid medical problems at Geisinger Medical Center, Danville, Pennsylvania. RESULTS The mean BMI in the predominantly white female cohort was 51.2. Approximately 21% of patients were homozygous for the FTO obesity SNP variant, 13% were homozygous for the INSIG2 obesity SNP variant, and 3.4% were homozygous for both. Mean BMIs in the groups homozygous for each of these genes were not significantly different from nonhomozygotes. However, FTO/INSIG2 double homozygotes and homozygote/heterozygote pairs had significantly higher BMIs than the other groups. CONCLUSION Increased BMI in morbid obesity is associated with a combination of FTO and INSIG2 SNPs.Arch Surg. 2008;143(3):235-240--></description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</subject><subject>Bariatric Surgery</subject><subject>Biological and medical sciences</subject><subject>Body fat</subject><subject>Female</subject><subject>General aspects</subject><subject>Genes</subject><subject>Genotype</subject><subject>Humans</subject><subject>Insulin</subject><subject>Intracellular Signaling Peptides and Proteins - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Proteins - genetics</subject><subject>Metabolic diseases</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - genetics</subject><subject>Obesity, Morbid - surgery</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proteins - genetics</subject><subject>Retrospective Studies</subject><subject>Rural Population</subject><issn>0004-0010</issn><issn>2168-6254</issn><issn>1538-3644</issn><issn>2168-6262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0M9P2zAUB3ALgaAU7uyCrEnjlu75R2zn2FUrq9StB9g4Wi-xM4zSBOzkwH-_VC1M4uQnvc_7yvoScsVgxgDYV4zVYxri3xkH0DOtj8iE5cJkQkl5TCYAILPRwRk5T-lpnLgp-Ck5Y0ZIzVUxId_mKXVVwD50Le1q-rOLZXB0U_oU-lf6EPpHurzfUGwdXf26W91yOm8a34SK_sEYsO3TBTmpsUn-8vBOye_l9_vFj2y9uV0t5usMudF9VrpCaeMFcKeVESVK55nhGlxd1sYprlAZWQtdeuYRKoOmkIUpCu9qbrgSU3Kzz32O3cvgU2-3IVW-abD13ZCsBgnSFDDCzx_gUzfEdvyb5YLnea7zHYI9qmKXUvS1fY5hi_HVMrC7cu1buXZXrtV6PLk-5A7l1rv_B4c2R_DlADBV2NQR2yqkd8eBKZXzXdCnvcMtvm_luAUl_gFf3Ymi</recordid><startdate>200803</startdate><enddate>200803</enddate><creator>Chu, Xin</creator><creator>Erdman, Robert</creator><creator>Susek, Meghan</creator><creator>Gerst, Heather</creator><creator>Derr, Kimberly</creator><creator>Al-Agha, Mouna</creator><creator>Wood, G. Craig</creator><creator>Hartman, Christina</creator><creator>Yeager, Stephanie</creator><creator>Blosky, Mary Ann</creator><creator>Krum, Wanda</creator><creator>Stewart, Walter F</creator><creator>Carey, David</creator><creator>Benotti, Peter</creator><creator>Still, Christopher D</creator><creator>Gerhard, Glenn S</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200803</creationdate><title>Association of Morbid Obesity With FTO and INSIG2 Allelic Variants</title><author>Chu, Xin ; Erdman, Robert ; Susek, Meghan ; Gerst, Heather ; Derr, Kimberly ; Al-Agha, Mouna ; Wood, G. Craig ; Hartman, Christina ; Yeager, Stephanie ; Blosky, Mary Ann ; Krum, Wanda ; Stewart, Walter F ; Carey, David ; Benotti, Peter ; Still, Christopher D ; Gerhard, Glenn S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a287t-bd9678e302d7683ba4de18270dfbf8d626a684f37be1ea0c8a8949899edf28263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</topic><topic>Bariatric Surgery</topic><topic>Biological and medical sciences</topic><topic>Body fat</topic><topic>Female</topic><topic>General aspects</topic><topic>Genes</topic><topic>Genotype</topic><topic>Humans</topic><topic>Insulin</topic><topic>Intracellular Signaling Peptides and Proteins - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Proteins - genetics</topic><topic>Metabolic diseases</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - genetics</topic><topic>Obesity, Morbid - surgery</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Proteins - genetics</topic><topic>Retrospective Studies</topic><topic>Rural Population</topic><toplevel>online_resources</toplevel><creatorcontrib>Chu, Xin</creatorcontrib><creatorcontrib>Erdman, Robert</creatorcontrib><creatorcontrib>Susek, Meghan</creatorcontrib><creatorcontrib>Gerst, Heather</creatorcontrib><creatorcontrib>Derr, Kimberly</creatorcontrib><creatorcontrib>Al-Agha, Mouna</creatorcontrib><creatorcontrib>Wood, G. Craig</creatorcontrib><creatorcontrib>Hartman, Christina</creatorcontrib><creatorcontrib>Yeager, Stephanie</creatorcontrib><creatorcontrib>Blosky, Mary Ann</creatorcontrib><creatorcontrib>Krum, Wanda</creatorcontrib><creatorcontrib>Stewart, Walter F</creatorcontrib><creatorcontrib>Carey, David</creatorcontrib><creatorcontrib>Benotti, Peter</creatorcontrib><creatorcontrib>Still, Christopher D</creatorcontrib><creatorcontrib>Gerhard, Glenn S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of surgery (Chicago. 1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chu, Xin</au><au>Erdman, Robert</au><au>Susek, Meghan</au><au>Gerst, Heather</au><au>Derr, Kimberly</au><au>Al-Agha, Mouna</au><au>Wood, G. Craig</au><au>Hartman, Christina</au><au>Yeager, Stephanie</au><au>Blosky, Mary Ann</au><au>Krum, Wanda</au><au>Stewart, Walter F</au><au>Carey, David</au><au>Benotti, Peter</au><au>Still, Christopher D</au><au>Gerhard, Glenn S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Morbid Obesity With FTO and INSIG2 Allelic Variants</atitle><jtitle>Archives of surgery (Chicago. 1960)</jtitle><addtitle>Arch Surg</addtitle><date>2008-03</date><risdate>2008</risdate><volume>143</volume><issue>3</issue><spage>235</spage><epage>240</epage><pages>235-240</pages><issn>0004-0010</issn><issn>2168-6254</issn><eissn>1538-3644</eissn><eissn>2168-6262</eissn><coden>ARSUAX</coden><abstract>OBJECTIVE To determine whether 2 single nucleotide polymorphisms (SNPs) in the obesity genes the fat mass and obesity associated gene (FTO) and the insulin induced gene 2 (INSIG2) are associated with class III, or morbid, obesity in patients undergoing bariatric weight loss operations. DESIGN Retrospective analysis of genotype and clinical data. SETTING Large rural tertiary care health system. PATIENTS A total of 707 adult patients with a body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) of at least 40 undergoing open or laparoscopic Roux-en-Y gastric bypass operations for morbid obesity or its comorbid medical problems at Geisinger Medical Center, Danville, Pennsylvania. RESULTS The mean BMI in the predominantly white female cohort was 51.2. Approximately 21% of patients were homozygous for the FTO obesity SNP variant, 13% were homozygous for the INSIG2 obesity SNP variant, and 3.4% were homozygous for both. Mean BMIs in the groups homozygous for each of these genes were not significantly different from nonhomozygotes. However, FTO/INSIG2 double homozygotes and homozygote/heterozygote pairs had significantly higher BMIs than the other groups. CONCLUSION Increased BMI in morbid obesity is associated with a combination of FTO and INSIG2 SNPs.Arch Surg. 2008;143(3):235-240--></abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>18347269</pmid><doi>10.1001/archsurg.2007.77</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Alleles Alpha-Ketoglutarate-Dependent Dioxygenase FTO Bariatric Surgery Biological and medical sciences Body fat Female General aspects Genes Genotype Humans Insulin Intracellular Signaling Peptides and Proteins - genetics Male Medical sciences Membrane Proteins - genetics Metabolic diseases Metabolism Middle Aged Obesity Obesity, Morbid - genetics Obesity, Morbid - surgery Polymorphism Polymorphism, Single Nucleotide Proteins - genetics Retrospective Studies Rural Population |
| title | Association of Morbid Obesity With FTO and INSIG2 Allelic Variants |
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