Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair

BRCA1 plays an important role in the homologous recombination (HR)-mediated DNA double-strand break (DSB) repair, but the mechanism is not clear. Here we describe that BRCA1 forms a complex with CtIP and MRN (Mre11/Rad50/Nbs1) in a cell cycle-dependent manner. Significantly, the complex formation, e...

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Veröffentlicht in:	The Journal of biological chemistry 2008-03, Vol.283 (12), p.7713-7720
Hauptverfasser:	Chen, Longchuan, Nievera, Christian J, Lee, Alan Yueh-Luen, Wu, Xiaohua
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Anhydride Hydrolases BRCA1 Protein - genetics BRCA1 Protein - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line Cyclin-Dependent Kinases - genetics Cyclin-Dependent Kinases - metabolism DNA Breaks, Double-Stranded - radiation effects DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endodeoxyribonucleases G2 Phase - physiology G2 Phase - radiation effects Humans MRE11 Homologue Protein Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Structure, Tertiary - genetics Radiation, Ionizing S Phase - physiology S Phase - radiation effects
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