The effects of exercise training on the kinetics of oxygen uptake in patients with chronic heart failure
Background Prolonged oxygen uptake kinetics (O2 kinetics), following the onset of a constant workload of exercise has been associated with a poor prognosis in patients with chronic heart failure. This study aimed to determine both continuous and interval training effects on the different O2-kinetics...
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| Veröffentlicht in: | European journal of cardiovascular prevention and rehabilitation 2007-04, Vol.14 (2), p.304-311 |
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| creator | Roditis, Petros Dimopoulos, Stavros Sakellariou, Dimitrios Sarafoglou, Serafim Kaldara, Elissavet Venetsanakos, John Vogiatzis, John Anastasiou-Nana, Maria Roussos, Charis Nanas, Serafim |
| description | Background
Prolonged oxygen uptake kinetics (O2 kinetics), following the onset of a constant workload of exercise has been associated with a poor prognosis in patients with chronic heart failure. This study aimed to determine both continuous and interval training effects on the different O2-kinetics phases in these patients.
Design
Twenty-one patients (60 ± 8 years) with stable chronic heart failure participated in a 36-session exercise rehabilitation program (three times weekly). Patients were randomly assigned to interval training (n = 11; 100% of peak work rate for 30 s, alternating with 30s-rest) and to continuous training (n = 10; 50% of peak work rate).
Methods
Before and after the completion of the program, all patients performed both incremental symptom-limited and constant workload submaximal cardiopulmonary exercise tests. Phase I O2-kinetics was evaluated by time (t), from the start of exercise until the onset of decreased respiratory exchange ratio and phase II by the time constant (τ) of the response from the end of phase I until steady state.
Results
After training, there was a significant increase in peak oxygen uptake and peak work rate in both continuous (15.3 ± 4.4 vs. 16.6 ± 4.5 ml/kg per min; P=0.03 and 81.8 ± 40.1 vs. 94.7 ± 46.1 W; P=0.03) and interval training groups (14.2 ± 3.1 vs. 15.4 ± 4.2 ml/kg per min; P=0.03 and 82.5 ± 24.1 vs. 93.7 ± 30.1 W; P=0.04). Patients who underwent interval training had a significant decrease in t (39.7 ± 3.7 to 36.1 ± 6.9s; P=0.05), but not τ (59.6 ± 9.4 to 58.9 ± 8.5 s; P=ns), whereas those assigned to continuous training had a significant decrease in both t (40.6 ± 6.1 to 36.4 ± 5.4 s; P=0.01) and τ (63.3 ± 23.6 to 42.5 ± 16.7 s; P=0.03).
Conclusions
Exercise training improves O2 kinetics in chronic heart failure patients. Both continuous and interval training improve phase I O2-kinetics, but continuous training results in superior improvement of the phase II O2-kinetics, an indirect index of muscle oxidative capacity. |
| doi_str_mv | 10.1097/01.hjr.0b013e32808621a3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70404173</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1097_01.hjr.0b013e32808621a3</sage_id><sourcerecordid>70404173</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3203-8d50ff83d5f0677653e8869765c35a2e67a0da9212bd7aed9e5709509a61d8523</originalsourceid><addsrcrecordid>eNqFkE9PAyEQxYnRqFG_gnLy1jrA7sIejfFfYuJFz4SyQ5fashXYqN9etI0mXpzLvMPvvck8Qs4YTBm08gLYtF_EKcyACRRcgWo4M2KHHHKo5KRSiu3-aCkOyElKCyjTAOdK7ZMDJquqUYwfkv6pR4rOoc2JDo7iO0brE9IcjQ8-zOkQaC7Miw-Yvf2GhvePOQY6rrN5QeoDXZvsMZSEN597avs4BG9pjyZm6oxfjhGPyZ4zy4Qn231Enm-un67uJg-Pt_dXlw8TKziIiepqcE6JrnbQSNnUApVq2iKsqA3HRhroTMsZn3XSYNdiLaGtoTUN61TNxRE53-Su4_A6Ysp65ZPF5dIEHMakJVRQMSkKKDegjUNKEZ1eR78y8UMz0F89a2C69Kz_9lycp9sT42yF3a9v22oBqg2QzBz1YhhjKC__m_sJ8qqKjA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70404173</pqid></control><display><type>article</type><title>The effects of exercise training on the kinetics of oxygen uptake in patients with chronic heart failure</title><source>SAGE Complete A-Z List</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Roditis, Petros ; Dimopoulos, Stavros ; Sakellariou, Dimitrios ; Sarafoglou, Serafim ; Kaldara, Elissavet ; Venetsanakos, John ; Vogiatzis, John ; Anastasiou-Nana, Maria ; Roussos, Charis ; Nanas, Serafim</creator><creatorcontrib>Roditis, Petros ; Dimopoulos, Stavros ; Sakellariou, Dimitrios ; Sarafoglou, Serafim ; Kaldara, Elissavet ; Venetsanakos, John ; Vogiatzis, John ; Anastasiou-Nana, Maria ; Roussos, Charis ; Nanas, Serafim</creatorcontrib><description>Background
Prolonged oxygen uptake kinetics (O2 kinetics), following the onset of a constant workload of exercise has been associated with a poor prognosis in patients with chronic heart failure. This study aimed to determine both continuous and interval training effects on the different O2-kinetics phases in these patients.
Design
Twenty-one patients (60 ± 8 years) with stable chronic heart failure participated in a 36-session exercise rehabilitation program (three times weekly). Patients were randomly assigned to interval training (n = 11; 100% of peak work rate for 30 s, alternating with 30s-rest) and to continuous training (n = 10; 50% of peak work rate).
Methods
Before and after the completion of the program, all patients performed both incremental symptom-limited and constant workload submaximal cardiopulmonary exercise tests. Phase I O2-kinetics was evaluated by time (t), from the start of exercise until the onset of decreased respiratory exchange ratio and phase II by the time constant (τ) of the response from the end of phase I until steady state.
Results
After training, there was a significant increase in peak oxygen uptake and peak work rate in both continuous (15.3 ± 4.4 vs. 16.6 ± 4.5 ml/kg per min; P=0.03 and 81.8 ± 40.1 vs. 94.7 ± 46.1 W; P=0.03) and interval training groups (14.2 ± 3.1 vs. 15.4 ± 4.2 ml/kg per min; P=0.03 and 82.5 ± 24.1 vs. 93.7 ± 30.1 W; P=0.04). Patients who underwent interval training had a significant decrease in t (39.7 ± 3.7 to 36.1 ± 6.9s; P=0.05), but not τ (59.6 ± 9.4 to 58.9 ± 8.5 s; P=ns), whereas those assigned to continuous training had a significant decrease in both t (40.6 ± 6.1 to 36.4 ± 5.4 s; P=0.01) and τ (63.3 ± 23.6 to 42.5 ± 16.7 s; P=0.03).
Conclusions
Exercise training improves O2 kinetics in chronic heart failure patients. Both continuous and interval training improve phase I O2-kinetics, but continuous training results in superior improvement of the phase II O2-kinetics, an indirect index of muscle oxidative capacity.</description><identifier>ISSN: 2047-4873</identifier><identifier>ISSN: 1741-8267</identifier><identifier>EISSN: 2047-4881</identifier><identifier>EISSN: 1741-8275</identifier><identifier>DOI: 10.1097/01.hjr.0b013e32808621a3</identifier><identifier>PMID: 17446812</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Chronic Disease ; Electrocardiography, Ambulatory ; Exercise Test ; Exercise Therapy ; Female ; Heart Failure - physiopathology ; Heart Failure - therapy ; Humans ; Linear Models ; Male ; Middle Aged ; Oxygen Consumption ; Physical Endurance ; Pulmonary Gas Exchange ; Research Design ; Tidal Volume ; Treatment Outcome</subject><ispartof>European journal of cardiovascular prevention and rehabilitation, 2007-04, Vol.14 (2), p.304-311</ispartof><rights>2007 European Society of Cardiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3203-8d50ff83d5f0677653e8869765c35a2e67a0da9212bd7aed9e5709509a61d8523</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1097/01.hjr.0b013e32808621a3$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1097/01.hjr.0b013e32808621a3$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21800,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17446812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roditis, Petros</creatorcontrib><creatorcontrib>Dimopoulos, Stavros</creatorcontrib><creatorcontrib>Sakellariou, Dimitrios</creatorcontrib><creatorcontrib>Sarafoglou, Serafim</creatorcontrib><creatorcontrib>Kaldara, Elissavet</creatorcontrib><creatorcontrib>Venetsanakos, John</creatorcontrib><creatorcontrib>Vogiatzis, John</creatorcontrib><creatorcontrib>Anastasiou-Nana, Maria</creatorcontrib><creatorcontrib>Roussos, Charis</creatorcontrib><creatorcontrib>Nanas, Serafim</creatorcontrib><title>The effects of exercise training on the kinetics of oxygen uptake in patients with chronic heart failure</title><title>European journal of cardiovascular prevention and rehabilitation</title><addtitle>Eur J Cardiovasc Prev Rehabil</addtitle><description>Background
Prolonged oxygen uptake kinetics (O2 kinetics), following the onset of a constant workload of exercise has been associated with a poor prognosis in patients with chronic heart failure. This study aimed to determine both continuous and interval training effects on the different O2-kinetics phases in these patients.
Design
Twenty-one patients (60 ± 8 years) with stable chronic heart failure participated in a 36-session exercise rehabilitation program (three times weekly). Patients were randomly assigned to interval training (n = 11; 100% of peak work rate for 30 s, alternating with 30s-rest) and to continuous training (n = 10; 50% of peak work rate).
Methods
Before and after the completion of the program, all patients performed both incremental symptom-limited and constant workload submaximal cardiopulmonary exercise tests. Phase I O2-kinetics was evaluated by time (t), from the start of exercise until the onset of decreased respiratory exchange ratio and phase II by the time constant (τ) of the response from the end of phase I until steady state.
Results
After training, there was a significant increase in peak oxygen uptake and peak work rate in both continuous (15.3 ± 4.4 vs. 16.6 ± 4.5 ml/kg per min; P=0.03 and 81.8 ± 40.1 vs. 94.7 ± 46.1 W; P=0.03) and interval training groups (14.2 ± 3.1 vs. 15.4 ± 4.2 ml/kg per min; P=0.03 and 82.5 ± 24.1 vs. 93.7 ± 30.1 W; P=0.04). Patients who underwent interval training had a significant decrease in t (39.7 ± 3.7 to 36.1 ± 6.9s; P=0.05), but not τ (59.6 ± 9.4 to 58.9 ± 8.5 s; P=ns), whereas those assigned to continuous training had a significant decrease in both t (40.6 ± 6.1 to 36.4 ± 5.4 s; P=0.01) and τ (63.3 ± 23.6 to 42.5 ± 16.7 s; P=0.03).
Conclusions
Exercise training improves O2 kinetics in chronic heart failure patients. Both continuous and interval training improve phase I O2-kinetics, but continuous training results in superior improvement of the phase II O2-kinetics, an indirect index of muscle oxidative capacity.</description><subject>Aged</subject><subject>Chronic Disease</subject><subject>Electrocardiography, Ambulatory</subject><subject>Exercise Test</subject><subject>Exercise Therapy</subject><subject>Female</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Failure - therapy</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxygen Consumption</subject><subject>Physical Endurance</subject><subject>Pulmonary Gas Exchange</subject><subject>Research Design</subject><subject>Tidal Volume</subject><subject>Treatment Outcome</subject><issn>2047-4873</issn><issn>1741-8267</issn><issn>2047-4881</issn><issn>1741-8275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9PAyEQxYnRqFG_gnLy1jrA7sIejfFfYuJFz4SyQ5fashXYqN9etI0mXpzLvMPvvck8Qs4YTBm08gLYtF_EKcyACRRcgWo4M2KHHHKo5KRSiu3-aCkOyElKCyjTAOdK7ZMDJquqUYwfkv6pR4rOoc2JDo7iO0brE9IcjQ8-zOkQaC7Miw-Yvf2GhvePOQY6rrN5QeoDXZvsMZSEN597avs4BG9pjyZm6oxfjhGPyZ4zy4Qn231Enm-un67uJg-Pt_dXlw8TKziIiepqcE6JrnbQSNnUApVq2iKsqA3HRhroTMsZn3XSYNdiLaGtoTUN61TNxRE53-Su4_A6Ysp65ZPF5dIEHMakJVRQMSkKKDegjUNKEZ1eR78y8UMz0F89a2C69Kz_9lycp9sT42yF3a9v22oBqg2QzBz1YhhjKC__m_sJ8qqKjA</recordid><startdate>200704</startdate><enddate>200704</enddate><creator>Roditis, Petros</creator><creator>Dimopoulos, Stavros</creator><creator>Sakellariou, Dimitrios</creator><creator>Sarafoglou, Serafim</creator><creator>Kaldara, Elissavet</creator><creator>Venetsanakos, John</creator><creator>Vogiatzis, John</creator><creator>Anastasiou-Nana, Maria</creator><creator>Roussos, Charis</creator><creator>Nanas, Serafim</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200704</creationdate><title>The effects of exercise training on the kinetics of oxygen uptake in patients with chronic heart failure</title><author>Roditis, Petros ; Dimopoulos, Stavros ; Sakellariou, Dimitrios ; Sarafoglou, Serafim ; Kaldara, Elissavet ; Venetsanakos, John ; Vogiatzis, John ; Anastasiou-Nana, Maria ; Roussos, Charis ; Nanas, Serafim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3203-8d50ff83d5f0677653e8869765c35a2e67a0da9212bd7aed9e5709509a61d8523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Chronic Disease</topic><topic>Electrocardiography, Ambulatory</topic><topic>Exercise Test</topic><topic>Exercise Therapy</topic><topic>Female</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Failure - therapy</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxygen Consumption</topic><topic>Physical Endurance</topic><topic>Pulmonary Gas Exchange</topic><topic>Research Design</topic><topic>Tidal Volume</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roditis, Petros</creatorcontrib><creatorcontrib>Dimopoulos, Stavros</creatorcontrib><creatorcontrib>Sakellariou, Dimitrios</creatorcontrib><creatorcontrib>Sarafoglou, Serafim</creatorcontrib><creatorcontrib>Kaldara, Elissavet</creatorcontrib><creatorcontrib>Venetsanakos, John</creatorcontrib><creatorcontrib>Vogiatzis, John</creatorcontrib><creatorcontrib>Anastasiou-Nana, Maria</creatorcontrib><creatorcontrib>Roussos, Charis</creatorcontrib><creatorcontrib>Nanas, Serafim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cardiovascular prevention and rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roditis, Petros</au><au>Dimopoulos, Stavros</au><au>Sakellariou, Dimitrios</au><au>Sarafoglou, Serafim</au><au>Kaldara, Elissavet</au><au>Venetsanakos, John</au><au>Vogiatzis, John</au><au>Anastasiou-Nana, Maria</au><au>Roussos, Charis</au><au>Nanas, Serafim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of exercise training on the kinetics of oxygen uptake in patients with chronic heart failure</atitle><jtitle>European journal of cardiovascular prevention and rehabilitation</jtitle><addtitle>Eur J Cardiovasc Prev Rehabil</addtitle><date>2007-04</date><risdate>2007</risdate><volume>14</volume><issue>2</issue><spage>304</spage><epage>311</epage><pages>304-311</pages><issn>2047-4873</issn><issn>1741-8267</issn><eissn>2047-4881</eissn><eissn>1741-8275</eissn><abstract>Background
Prolonged oxygen uptake kinetics (O2 kinetics), following the onset of a constant workload of exercise has been associated with a poor prognosis in patients with chronic heart failure. This study aimed to determine both continuous and interval training effects on the different O2-kinetics phases in these patients.
Design
Twenty-one patients (60 ± 8 years) with stable chronic heart failure participated in a 36-session exercise rehabilitation program (three times weekly). Patients were randomly assigned to interval training (n = 11; 100% of peak work rate for 30 s, alternating with 30s-rest) and to continuous training (n = 10; 50% of peak work rate).
Methods
Before and after the completion of the program, all patients performed both incremental symptom-limited and constant workload submaximal cardiopulmonary exercise tests. Phase I O2-kinetics was evaluated by time (t), from the start of exercise until the onset of decreased respiratory exchange ratio and phase II by the time constant (τ) of the response from the end of phase I until steady state.
Results
After training, there was a significant increase in peak oxygen uptake and peak work rate in both continuous (15.3 ± 4.4 vs. 16.6 ± 4.5 ml/kg per min; P=0.03 and 81.8 ± 40.1 vs. 94.7 ± 46.1 W; P=0.03) and interval training groups (14.2 ± 3.1 vs. 15.4 ± 4.2 ml/kg per min; P=0.03 and 82.5 ± 24.1 vs. 93.7 ± 30.1 W; P=0.04). Patients who underwent interval training had a significant decrease in t (39.7 ± 3.7 to 36.1 ± 6.9s; P=0.05), but not τ (59.6 ± 9.4 to 58.9 ± 8.5 s; P=ns), whereas those assigned to continuous training had a significant decrease in both t (40.6 ± 6.1 to 36.4 ± 5.4 s; P=0.01) and τ (63.3 ± 23.6 to 42.5 ± 16.7 s; P=0.03).
Conclusions
Exercise training improves O2 kinetics in chronic heart failure patients. Both continuous and interval training improve phase I O2-kinetics, but continuous training results in superior improvement of the phase II O2-kinetics, an indirect index of muscle oxidative capacity.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>17446812</pmid><doi>10.1097/01.hjr.0b013e32808621a3</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of cardiovascular prevention and rehabilitation, 2007-04, Vol.14 (2), p.304-311 |
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| source | SAGE Complete A-Z List; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Chronic Disease Electrocardiography, Ambulatory Exercise Test Exercise Therapy Female Heart Failure - physiopathology Heart Failure - therapy Humans Linear Models Male Middle Aged Oxygen Consumption Physical Endurance Pulmonary Gas Exchange Research Design Tidal Volume Treatment Outcome |
| title | The effects of exercise training on the kinetics of oxygen uptake in patients with chronic heart failure |
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