Highway to the inner nuclear membrane: rules for the road
Transport of soluble proteins into the nucleus depends either on binding a protein-transport complex or on being small enough to diffuse in. Recent studies indicate that the delivery of integral membrane proteins into the inner nuclear membrane is governed by the same rules. To enter the nucleus a p...
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| Veröffentlicht in: | Nature reviews. Molecular cell biology 2007-05, Vol.8 (5), p.414-420 |
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| container_title | Nature reviews. Molecular cell biology |
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| creator | King, Megan C Lusk, C. Patrick Blobel, Günter |
| description | Transport of soluble proteins into the nucleus depends either on binding a protein-transport complex or on being small enough to diffuse in. Recent studies indicate that the delivery of integral membrane proteins into the inner nuclear membrane is governed by the same rules.
To enter the nucleus a protein must be chaperoned by a transport factor through the nuclear pore complex or it must be small enough to pass through by diffusion. Although these principles have long described the nuclear import of soluble proteins, recent evidence indicates that they also apply to the import of integral inner nuclear membrane proteins. Here we develop a set of rules that might govern the transport of proteins to the inner nuclear membrane. |
| doi_str_mv | 10.1038/nrm2165 |
| format | Article |
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To enter the nucleus a protein must be chaperoned by a transport factor through the nuclear pore complex or it must be small enough to pass through by diffusion. Although these principles have long described the nuclear import of soluble proteins, recent evidence indicates that they also apply to the import of integral inner nuclear membrane proteins. Here we develop a set of rules that might govern the transport of proteins to the inner nuclear membrane.</description><identifier>ISSN: 1471-0072</identifier><identifier>EISSN: 1471-0080</identifier><identifier>DOI: 10.1038/nrm2165</identifier><identifier>PMID: 17440484</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Active Transport, Cell Nucleus - physiology ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Cancer Research ; Cell Biology ; Cell Nucleus - metabolism ; Developmental Biology ; Electron microscopes ; Genetic aspects ; Humans ; Karyopherins - physiology ; Life Sciences ; Localization ; Membranes ; Models, Biological ; Nuclear Envelope - physiology ; Nuclear Localization Signals - physiology ; Nuclear membranes ; Nuclear Pore - physiology ; Nuclear Pore Complex Proteins - physiology ; opinion-2 ; Physiological aspects ; Protein Transport - physiology ; Proteins ; Stem Cells ; Structure ; Yeast</subject><ispartof>Nature reviews. Molecular cell biology, 2007-05, Vol.8 (5), p.414-420</ispartof><rights>Springer Nature Limited 2007</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-46659470d28c4b958a509955197bf23b9a45beec7620233677cd61f6b8f395633</citedby><cites>FETCH-LOGICAL-c528t-46659470d28c4b958a509955197bf23b9a45beec7620233677cd61f6b8f395633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17440484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>King, Megan C</creatorcontrib><creatorcontrib>Lusk, C. Patrick</creatorcontrib><creatorcontrib>Blobel, Günter</creatorcontrib><title>Highway to the inner nuclear membrane: rules for the road</title><title>Nature reviews. Molecular cell biology</title><addtitle>Nat Rev Mol Cell Biol</addtitle><addtitle>Nat Rev Mol Cell Biol</addtitle><description>Transport of soluble proteins into the nucleus depends either on binding a protein-transport complex or on being small enough to diffuse in. Recent studies indicate that the delivery of integral membrane proteins into the inner nuclear membrane is governed by the same rules.
To enter the nucleus a protein must be chaperoned by a transport factor through the nuclear pore complex or it must be small enough to pass through by diffusion. Although these principles have long described the nuclear import of soluble proteins, recent evidence indicates that they also apply to the import of integral inner nuclear membrane proteins. Here we develop a set of rules that might govern the transport of proteins to the inner nuclear membrane.</description><subject>Active Transport, Cell Nucleus - physiology</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer Research</subject><subject>Cell Biology</subject><subject>Cell Nucleus - metabolism</subject><subject>Developmental Biology</subject><subject>Electron microscopes</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Karyopherins - physiology</subject><subject>Life Sciences</subject><subject>Localization</subject><subject>Membranes</subject><subject>Models, Biological</subject><subject>Nuclear Envelope - physiology</subject><subject>Nuclear Localization Signals - physiology</subject><subject>Nuclear membranes</subject><subject>Nuclear Pore - physiology</subject><subject>Nuclear Pore Complex Proteins - physiology</subject><subject>opinion-2</subject><subject>Physiological aspects</subject><subject>Protein Transport - physiology</subject><subject>Proteins</subject><subject>Stem Cells</subject><subject>Structure</subject><subject>Yeast</subject><issn>1471-0072</issn><issn>1471-0080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpt0VtLHTEQAOBQKvVW-gtalgpaH47NPRvfRLyBIKh9Dtns7HFlN9Fkl-q_N7pH5diSh4TMN8MMg9A3gvcIZuVvH3tKpPiE1ghXZIZxiT-_vRVdResp3WJMJFHiC1olinPMS76G9Gk7v_lrH4shFMMNFK33EAs_ug5sLHroq2g97Bdx7CAVTYgvKgZbb6KVxnYJvi7uDfTn-Oj68HR2fnFydnhwPnOClsOMSyk0V7impeOVFqUVWGshiFZVQ1mlLRcVgFOSYsqYVMrVkjSyKhumhWRsA21Pde9iuB8hDaZvk4Ouy32FMRmF8yi41Bn-_ABvwxh97s1QmttgnKqMtiY0tx2Y1jdhiNY9VzQHRGlGJJckq73_qHxq6FsXPDRt_l9K2F1KyGaAh2Fux5TM2dXlst2ZrIshpQiNuYttb-OjIdg8b9Mstpnlj8VEY9VD_e4W68vg1wRSDvk5xPeR_631faLeDmOEt1qv8SdCzqwz</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>King, Megan C</creator><creator>Lusk, C. 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Patrick ; Blobel, Günter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-46659470d28c4b958a509955197bf23b9a45beec7620233677cd61f6b8f395633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Active Transport, Cell Nucleus - physiology</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cancer Research</topic><topic>Cell Biology</topic><topic>Cell Nucleus - metabolism</topic><topic>Developmental Biology</topic><topic>Electron microscopes</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Karyopherins - physiology</topic><topic>Life Sciences</topic><topic>Localization</topic><topic>Membranes</topic><topic>Models, Biological</topic><topic>Nuclear Envelope - physiology</topic><topic>Nuclear Localization Signals - physiology</topic><topic>Nuclear membranes</topic><topic>Nuclear Pore - physiology</topic><topic>Nuclear Pore Complex Proteins - physiology</topic><topic>opinion-2</topic><topic>Physiological aspects</topic><topic>Protein Transport - physiology</topic><topic>Proteins</topic><topic>Stem Cells</topic><topic>Structure</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>King, Megan C</creatorcontrib><creatorcontrib>Lusk, C. 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Molecular cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>King, Megan C</au><au>Lusk, C. Patrick</au><au>Blobel, Günter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highway to the inner nuclear membrane: rules for the road</atitle><jtitle>Nature reviews. Molecular cell biology</jtitle><stitle>Nat Rev Mol Cell Biol</stitle><addtitle>Nat Rev Mol Cell Biol</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>8</volume><issue>5</issue><spage>414</spage><epage>420</epage><pages>414-420</pages><issn>1471-0072</issn><eissn>1471-0080</eissn><abstract>Transport of soluble proteins into the nucleus depends either on binding a protein-transport complex or on being small enough to diffuse in. Recent studies indicate that the delivery of integral membrane proteins into the inner nuclear membrane is governed by the same rules.
To enter the nucleus a protein must be chaperoned by a transport factor through the nuclear pore complex or it must be small enough to pass through by diffusion. Although these principles have long described the nuclear import of soluble proteins, recent evidence indicates that they also apply to the import of integral inner nuclear membrane proteins. Here we develop a set of rules that might govern the transport of proteins to the inner nuclear membrane.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>17440484</pmid><doi>10.1038/nrm2165</doi><tpages>7</tpages></addata></record> |
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| subjects | Active Transport, Cell Nucleus - physiology Animals Biochemistry Biomedical and Life Sciences Cancer Research Cell Biology Cell Nucleus - metabolism Developmental Biology Electron microscopes Genetic aspects Humans Karyopherins - physiology Life Sciences Localization Membranes Models, Biological Nuclear Envelope - physiology Nuclear Localization Signals - physiology Nuclear membranes Nuclear Pore - physiology Nuclear Pore Complex Proteins - physiology opinion-2 Physiological aspects Protein Transport - physiology Proteins Stem Cells Structure Yeast |
| title | Highway to the inner nuclear membrane: rules for the road |
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