Increased Tolerance to Ischemic Neuronal Damage by Knockdown of Na+-Ca2+ Exchanger Isoform 1

: We hypothesize that stimulation of Na+–K+–Cl+ cotransporter (NKCC1) causes Na+ overload that may lead to reversal of Na+–Ca2+ exchanger isoform 1 (NCX1) and ischemic neuronal damage. NCX1 protein expression and Ca2+ influx via reversal of NCX were decreased by ∼70% in NCX1+/− neurons. Compared to...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2007-03, Vol.1099 (1), p.292-305
Hauptverfasser:	LUO, JING, WANG, YANPING, CHEN, XINZHI, CHEN, HAI, KINTNER, DOUGLAS B., SHULL, GARY E., PHILIPSON, KENNETH D., SUN, DANDAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Animals Base Sequence Blotting, Western Ca2+ overload Cells, Cultured Electrophoresis, Polyacrylamide Gel Female focal ischemia infarction Mice Mice, Transgenic neuronal death Protein Isoforms - physiology reversal of NCX RNA, Small Interfering Sodium-Calcium Exchanger - physiology
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