Oral lichen planus: controversies surrounding malignant transformation
Studies of the malignant potential of oral lichen planus (OLP) have been hampered by inconsistencies in the diagnostic criteria used for OLP, the criteria adopted to identify a true case of malignant transformation in OLP, the risk factors for malignant transformation and the optimum management of p...
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| Veröffentlicht in: | Oral diseases 2008-04, Vol.14 (3), p.229-243 |
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| creator | Gonzalez-Moles, MA Scully, C Gil-Montoya, JA |
| description | Studies of the malignant potential of oral lichen planus (OLP) have been hampered by inconsistencies in the diagnostic criteria used for OLP, the criteria adopted to identify a true case of malignant transformation in OLP, the risk factors for malignant transformation and the optimum management of patients to ensure the early diagnosis of transformation. Consensus remains elusive, and leading workers in this field have recently published conflicting reports on the malignant potential of OLP and on the important question of the advisability of excluding patients with epithelial dysplasia or a tobacco habit from studies on this issue. The present review outlines these debates and proposes a possible a molecular basis for the malignant transformation in this disease. |
| doi_str_mv | 10.1111/j.1601-0825.2008.01441.x |
| format | Article |
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Consensus remains elusive, and leading workers in this field have recently published conflicting reports on the malignant potential of OLP and on the important question of the advisability of excluding patients with epithelial dysplasia or a tobacco habit from studies on this issue. The present review outlines these debates and proposes a possible a molecular basis for the malignant transformation in this disease.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/j.1601-0825.2008.01441.x</identifier><identifier>PMID: 18298420</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Cell Transformation, Neoplastic - genetics ; Dentistry ; Hepatitis C - complications ; Humans ; Immunosuppression - adverse effects ; Lichen Planus, Oral - complications ; Lichen Planus, Oral - diagnosis ; Lichen Planus, Oral - pathology ; Lichenoid Eruptions - pathology ; malignant transformation ; Mouth Neoplasms - pathology ; Mutation ; oral cancer ; oral lichen planus ; Risk Factors ; Sex Factors ; Smoking</subject><ispartof>Oral diseases, 2008-04, Vol.14 (3), p.229-243</ispartof><rights>2008 The Authors</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4711-e75b2c640631e8729765d5cbc87c4319d7e0e4425a3dcb2c20c4f53d74f7604b3</citedby><cites>FETCH-LOGICAL-c4711-e75b2c640631e8729765d5cbc87c4319d7e0e4425a3dcb2c20c4f53d74f7604b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1601-0825.2008.01441.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1601-0825.2008.01441.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18298420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gonzalez-Moles, MA</creatorcontrib><creatorcontrib>Scully, C</creatorcontrib><creatorcontrib>Gil-Montoya, JA</creatorcontrib><title>Oral lichen planus: controversies surrounding malignant transformation</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Studies of the malignant potential of oral lichen planus (OLP) have been hampered by inconsistencies in the diagnostic criteria used for OLP, the criteria adopted to identify a true case of malignant transformation in OLP, the risk factors for malignant transformation and the optimum management of patients to ensure the early diagnosis of transformation. Consensus remains elusive, and leading workers in this field have recently published conflicting reports on the malignant potential of OLP and on the important question of the advisability of excluding patients with epithelial dysplasia or a tobacco habit from studies on this issue. The present review outlines these debates and proposes a possible a molecular basis for the malignant transformation in this disease.</description><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Dentistry</subject><subject>Hepatitis C - complications</subject><subject>Humans</subject><subject>Immunosuppression - adverse effects</subject><subject>Lichen Planus, Oral - complications</subject><subject>Lichen Planus, Oral - diagnosis</subject><subject>Lichen Planus, Oral - pathology</subject><subject>Lichenoid Eruptions - pathology</subject><subject>malignant transformation</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mutation</subject><subject>oral cancer</subject><subject>oral lichen planus</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Smoking</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0E4lH4BZQVu4TxK06RWCBKKVJFN7x2lus44JI4xU6g_XsSWsGW2cxIPnfGOghFGBLc1fkiwSngGDLCEwKQJYAZw8lqBx3-Pux2M-Us5oS-HKCjEBYAWAwp2UcHOCPDjBE4ROOZV2VUWv1mXLQslWvDRaRr1_j60_hgTYhC633duty616hSpX11yjVR45ULRe0r1djaHaO9QpXBnGz7AD2Obx6uJ_F0dnt3fTWNNRMYx0bwOdEpg5RikwkyFCnPuZ7rTGhG8TAXBgxjhCua644koFnBaS5YIVJgczpAZ5u9S19_tCY0srJBm7L7uKnbIAUwoIxCB2YbUPs6BG8KufS2Un4tMcjeoVzIXpXsVcneofxxKFdd9HR7o51XJv8LbqV1wOUG-LKlWf97sZyN7vqpy8ebvA2NWf3mlX-XqaCCy-f7Wzl9ephMJ6MnOabfE6-Plg</recordid><startdate>200804</startdate><enddate>200804</enddate><creator>Gonzalez-Moles, MA</creator><creator>Scully, C</creator><creator>Gil-Montoya, JA</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200804</creationdate><title>Oral lichen planus: controversies surrounding malignant transformation</title><author>Gonzalez-Moles, MA ; Scully, C ; Gil-Montoya, JA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4711-e75b2c640631e8729765d5cbc87c4319d7e0e4425a3dcb2c20c4f53d74f7604b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Dentistry</topic><topic>Hepatitis C - complications</topic><topic>Humans</topic><topic>Immunosuppression - adverse effects</topic><topic>Lichen Planus, Oral - complications</topic><topic>Lichen Planus, Oral - diagnosis</topic><topic>Lichen Planus, Oral - pathology</topic><topic>Lichenoid Eruptions - pathology</topic><topic>malignant transformation</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mutation</topic><topic>oral cancer</topic><topic>oral lichen planus</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gonzalez-Moles, MA</creatorcontrib><creatorcontrib>Scully, C</creatorcontrib><creatorcontrib>Gil-Montoya, JA</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gonzalez-Moles, MA</au><au>Scully, C</au><au>Gil-Montoya, JA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral lichen planus: controversies surrounding malignant transformation</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2008-04</date><risdate>2008</risdate><volume>14</volume><issue>3</issue><spage>229</spage><epage>243</epage><pages>229-243</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Studies of the malignant potential of oral lichen planus (OLP) have been hampered by inconsistencies in the diagnostic criteria used for OLP, the criteria adopted to identify a true case of malignant transformation in OLP, the risk factors for malignant transformation and the optimum management of patients to ensure the early diagnosis of transformation. 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| identifier | ISSN: 1354-523X |
| ispartof | Oral diseases, 2008-04, Vol.14 (3), p.229-243 |
| issn | 1354-523X 1601-0825 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Cell Transformation, Neoplastic - genetics Dentistry Hepatitis C - complications Humans Immunosuppression - adverse effects Lichen Planus, Oral - complications Lichen Planus, Oral - diagnosis Lichen Planus, Oral - pathology Lichenoid Eruptions - pathology malignant transformation Mouth Neoplasms - pathology Mutation oral cancer oral lichen planus Risk Factors Sex Factors Smoking |
| title | Oral lichen planus: controversies surrounding malignant transformation |
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