Intrinsic ability of GM + IL-4 but not Flt3L-induced rat dendritic cells to promote allogeneic T cell hyporesponsiveness

Abstract The influence of GM + IL-4 and Flt3 ligand (FL) on phenotype and function of BM-derived DC from Lewis rats was investigated. GM + IL-4-induced DC, despite expression of CD80/CD86, were less stimulatory than FL-induced DC that expressed low CD80/CD86 and were efficient stimulators of allogen...

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Veröffentlicht in:	Clinical Immunology 2007-05, Vol.123 (2), p.176-189
Hauptverfasser:	Taieb, Aurele, Breitinger, Jeremy J, Unadkat, Jignesh V, Shufesky, William J, Morelli, Adrian E, Thomson, Angus W, Lee, W.P. Andrew, Feili-Hariri, Maryam
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Monoclonal - pharmacology Antigen-Presenting Cells - drug effects Antigen-Presenting Cells - immunology Antigens, CD - analysis Antigens, CD - metabolism Apoptosis - drug effects Apoptosis - immunology Biological and medical sciences Bone marrow Cell Differentiation - drug effects Cell Differentiation - immunology Cell Transplantation Cytokines Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Dinucleoside Phosphates - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Histocompatibility Antigens - analysis Hyporesponsiveness Immune Tolerance - drug effects Immune Tolerance - immunology Immunopathology Interferons - metabolism Interleukin-4 - pharmacology Isoantigens - immunology Lipopolysaccharides - pharmacology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Male Medical sciences Membrane Proteins - pharmacology Passive-cell-death Rat Rats Rats, Inbred ACI Rats, Inbred Lew Rats, Inbred WF Receptors, Antigen, T-Cell - immunology T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism
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