Comparing Glaucomatous Optic Neuropathy in Primary Open Angle and Primary Angle Closure Glaucoma Eyes by Scanning Laser Polarimetry-Variable Corneal Compensation
PURPOSETo study the retinal nerve fiber layer thickness difference between high-tension primary open angle glaucoma (HT-POAG) and primary angle closure glaucoma (PACG) eyes using scanning laser polarimetry-variable corneal compensation (GDx VCC) in Taiwan-Chinese population; to evaluate the usefulne...
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| Veröffentlicht in: | Journal of glaucoma 2008-03, Vol.17 (2), p.105-110 |
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| creator | Chen, Hsin-Yi Huang, Mei-Ling Tsai, Yi-Yu Hung, Por-Tying Lin, En-Ju |
| description | PURPOSETo study the retinal nerve fiber layer thickness difference between high-tension primary open angle glaucoma (HT-POAG) and primary angle closure glaucoma (PACG) eyes using scanning laser polarimetry-variable corneal compensation (GDx VCC) in Taiwan-Chinese population; to evaluate the usefulness of the GDx VCC for detecting POAG and PACG eyes in Taiwan-Chinese population.
PATIENTS AND METHODSThe study comprised 88 early to moderate glaucomatous eyes (one randomly selected eye from 47 HT-POAG patients and 41 PACG patients) and the control group consisted of 45 age-matched eyes from 45 normal individuals. Each subject underwent retinal nerve fiber layer thickness measurement by GDx VCC and Humphrey Field Analyzer visual field testing. Measured GDx VCC parameters were compared among groups. We also calculated the area under the receive operator characteristic (AROC) curve, corresponding sensitivity/specificity and best cut off value for each parameter in differentiating normal from POAG and PACG eyes.
RESULTSThere was no significant difference between HT-POAG and PACG eyes in each parameter. The parameter with the best AROC curve for differentiating normal from POAG eye was nerve fiber indicator (AROC, 0.779; sensitivity=57.4%, specificity=100%; best cut off value >27). The parameter with the best AROC curves for differentiating normal from PACG eyes was temporal-superior-nasal-inferior-temporal average (AROC, 0.829; sensitivity=46.3%, specificity=100%, best cut off value |
| doi_str_mv | 10.1097/IJG.0b013e31814b9971 |
| format | Article |
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PATIENTS AND METHODSThe study comprised 88 early to moderate glaucomatous eyes (one randomly selected eye from 47 HT-POAG patients and 41 PACG patients) and the control group consisted of 45 age-matched eyes from 45 normal individuals. Each subject underwent retinal nerve fiber layer thickness measurement by GDx VCC and Humphrey Field Analyzer visual field testing. Measured GDx VCC parameters were compared among groups. We also calculated the area under the receive operator characteristic (AROC) curve, corresponding sensitivity/specificity and best cut off value for each parameter in differentiating normal from POAG and PACG eyes.
RESULTSThere was no significant difference between HT-POAG and PACG eyes in each parameter. The parameter with the best AROC curve for differentiating normal from POAG eye was nerve fiber indicator (AROC, 0.779; sensitivity=57.4%, specificity=100%; best cut off value >27). The parameter with the best AROC curves for differentiating normal from PACG eyes was temporal-superior-nasal-inferior-temporal average (AROC, 0.829; sensitivity=46.3%, specificity=100%, best cut off value <51.7).
CONCLUSIONSThere was no significant difference between the HT-POAG and PACG eyes as far as the various parameters were concerned. GDx VCC shows fair discriminating ability in distinguishing normal from POAG and PACG eyes in Taiwan Chinese population.</description><identifier>ISSN: 1057-0829</identifier><identifier>EISSN: 1536-481X</identifier><identifier>DOI: 10.1097/IJG.0b013e31814b9971</identifier><identifier>PMID: 18344755</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Area Under Curve ; Birefringence ; Cornea - physiology ; Cross-Sectional Studies ; Diagnostic Techniques, Ophthalmological ; Glaucoma, Angle-Closure - diagnosis ; Glaucoma, Open-Angle - diagnosis ; Humans ; Intraocular Pressure ; Lasers ; Middle Aged ; Nerve Fibers - pathology ; Optic Nerve Diseases - diagnosis ; Prospective Studies ; Retinal Ganglion Cells - pathology ; ROC Curve ; Sensitivity and Specificity ; Visual Field Tests - methods ; Visual Fields</subject><ispartof>Journal of glaucoma, 2008-03, Vol.17 (2), p.105-110</ispartof><rights>2008 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4164-8c93a56c4490514edb7a4360a2b033fd4e5c18ca3b42125f22ba5c1bb3ca79ce3</citedby><cites>FETCH-LOGICAL-c4164-8c93a56c4490514edb7a4360a2b033fd4e5c18ca3b42125f22ba5c1bb3ca79ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18344755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Hsin-Yi</creatorcontrib><creatorcontrib>Huang, Mei-Ling</creatorcontrib><creatorcontrib>Tsai, Yi-Yu</creatorcontrib><creatorcontrib>Hung, Por-Tying</creatorcontrib><creatorcontrib>Lin, En-Ju</creatorcontrib><title>Comparing Glaucomatous Optic Neuropathy in Primary Open Angle and Primary Angle Closure Glaucoma Eyes by Scanning Laser Polarimetry-Variable Corneal Compensation</title><title>Journal of glaucoma</title><addtitle>J Glaucoma</addtitle><description>PURPOSETo study the retinal nerve fiber layer thickness difference between high-tension primary open angle glaucoma (HT-POAG) and primary angle closure glaucoma (PACG) eyes using scanning laser polarimetry-variable corneal compensation (GDx VCC) in Taiwan-Chinese population; to evaluate the usefulness of the GDx VCC for detecting POAG and PACG eyes in Taiwan-Chinese population.
PATIENTS AND METHODSThe study comprised 88 early to moderate glaucomatous eyes (one randomly selected eye from 47 HT-POAG patients and 41 PACG patients) and the control group consisted of 45 age-matched eyes from 45 normal individuals. Each subject underwent retinal nerve fiber layer thickness measurement by GDx VCC and Humphrey Field Analyzer visual field testing. Measured GDx VCC parameters were compared among groups. We also calculated the area under the receive operator characteristic (AROC) curve, corresponding sensitivity/specificity and best cut off value for each parameter in differentiating normal from POAG and PACG eyes.
RESULTSThere was no significant difference between HT-POAG and PACG eyes in each parameter. The parameter with the best AROC curve for differentiating normal from POAG eye was nerve fiber indicator (AROC, 0.779; sensitivity=57.4%, specificity=100%; best cut off value >27). The parameter with the best AROC curves for differentiating normal from PACG eyes was temporal-superior-nasal-inferior-temporal average (AROC, 0.829; sensitivity=46.3%, specificity=100%, best cut off value <51.7).
CONCLUSIONSThere was no significant difference between the HT-POAG and PACG eyes as far as the various parameters were concerned. GDx VCC shows fair discriminating ability in distinguishing normal from POAG and PACG eyes in Taiwan Chinese population.</description><subject>Area Under Curve</subject><subject>Birefringence</subject><subject>Cornea - physiology</subject><subject>Cross-Sectional Studies</subject><subject>Diagnostic Techniques, Ophthalmological</subject><subject>Glaucoma, Angle-Closure - diagnosis</subject><subject>Glaucoma, Open-Angle - diagnosis</subject><subject>Humans</subject><subject>Intraocular Pressure</subject><subject>Lasers</subject><subject>Middle Aged</subject><subject>Nerve Fibers - pathology</subject><subject>Optic Nerve Diseases - diagnosis</subject><subject>Prospective Studies</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Visual Field Tests - methods</subject><subject>Visual Fields</subject><issn>1057-0829</issn><issn>1536-481X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUctuFDEQHCEQCYE_QMgnbhPaj3kdo1VYglYkEg9xs9re3uyAxx7sGUXzOfwpXu0qkThY7i53VVtVRfGWwyWHrvlw83l9CQa4JMlbrkzXNfxZcc4rWZeq5T-f5xqqpoRWdGfFq5R-AQgQgr8szngrlWqq6rz4uwrDiLH392ztcLZhwCnMid2OU2_ZF5pjGHHaL6z37C72A8Ylv5FnV_7eEUO_fYSPyMqFNEd6VGPXCyVmFvbVoveHPRtMFNldcHntQFNcyh-5QnMgh-gJHTt8inzCqQ_-dfFihy7Rm9N9UXz_eP1t9anc3K5vVleb0ipeq7K1ncSqtkp1UHFFW9OgkjWgMCDlbquosry1KI0SXFQ7IQxmxBhpseksyYvi_VF3jOHPTGnSQ58sOYeesiO6AQWiqeo8qI6DNoaUIu30eHRAc9CHaHSORv8fTaa9O-nPZqDtE-mUxZPuQ3ATxfTbzQ8U9T4bMu01ANScd20pAFqQuS3zASX_AUQvnXk</recordid><startdate>200803</startdate><enddate>200803</enddate><creator>Chen, Hsin-Yi</creator><creator>Huang, Mei-Ling</creator><creator>Tsai, Yi-Yu</creator><creator>Hung, Por-Tying</creator><creator>Lin, En-Ju</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200803</creationdate><title>Comparing Glaucomatous Optic Neuropathy in Primary Open Angle and Primary Angle Closure Glaucoma Eyes by Scanning Laser Polarimetry-Variable Corneal Compensation</title><author>Chen, Hsin-Yi ; Huang, Mei-Ling ; Tsai, Yi-Yu ; Hung, Por-Tying ; Lin, En-Ju</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4164-8c93a56c4490514edb7a4360a2b033fd4e5c18ca3b42125f22ba5c1bb3ca79ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Area Under Curve</topic><topic>Birefringence</topic><topic>Cornea - physiology</topic><topic>Cross-Sectional Studies</topic><topic>Diagnostic Techniques, Ophthalmological</topic><topic>Glaucoma, Angle-Closure - diagnosis</topic><topic>Glaucoma, Open-Angle - diagnosis</topic><topic>Humans</topic><topic>Intraocular Pressure</topic><topic>Lasers</topic><topic>Middle Aged</topic><topic>Nerve Fibers - pathology</topic><topic>Optic Nerve Diseases - diagnosis</topic><topic>Prospective Studies</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Visual Field Tests - methods</topic><topic>Visual Fields</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Hsin-Yi</creatorcontrib><creatorcontrib>Huang, Mei-Ling</creatorcontrib><creatorcontrib>Tsai, Yi-Yu</creatorcontrib><creatorcontrib>Hung, Por-Tying</creatorcontrib><creatorcontrib>Lin, En-Ju</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of glaucoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Hsin-Yi</au><au>Huang, Mei-Ling</au><au>Tsai, Yi-Yu</au><au>Hung, Por-Tying</au><au>Lin, En-Ju</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparing Glaucomatous Optic Neuropathy in Primary Open Angle and Primary Angle Closure Glaucoma Eyes by Scanning Laser Polarimetry-Variable Corneal Compensation</atitle><jtitle>Journal of glaucoma</jtitle><addtitle>J Glaucoma</addtitle><date>2008-03</date><risdate>2008</risdate><volume>17</volume><issue>2</issue><spage>105</spage><epage>110</epage><pages>105-110</pages><issn>1057-0829</issn><eissn>1536-481X</eissn><abstract>PURPOSETo study the retinal nerve fiber layer thickness difference between high-tension primary open angle glaucoma (HT-POAG) and primary angle closure glaucoma (PACG) eyes using scanning laser polarimetry-variable corneal compensation (GDx VCC) in Taiwan-Chinese population; to evaluate the usefulness of the GDx VCC for detecting POAG and PACG eyes in Taiwan-Chinese population.
PATIENTS AND METHODSThe study comprised 88 early to moderate glaucomatous eyes (one randomly selected eye from 47 HT-POAG patients and 41 PACG patients) and the control group consisted of 45 age-matched eyes from 45 normal individuals. Each subject underwent retinal nerve fiber layer thickness measurement by GDx VCC and Humphrey Field Analyzer visual field testing. Measured GDx VCC parameters were compared among groups. We also calculated the area under the receive operator characteristic (AROC) curve, corresponding sensitivity/specificity and best cut off value for each parameter in differentiating normal from POAG and PACG eyes.
RESULTSThere was no significant difference between HT-POAG and PACG eyes in each parameter. The parameter with the best AROC curve for differentiating normal from POAG eye was nerve fiber indicator (AROC, 0.779; sensitivity=57.4%, specificity=100%; best cut off value >27). The parameter with the best AROC curves for differentiating normal from PACG eyes was temporal-superior-nasal-inferior-temporal average (AROC, 0.829; sensitivity=46.3%, specificity=100%, best cut off value <51.7).
CONCLUSIONSThere was no significant difference between the HT-POAG and PACG eyes as far as the various parameters were concerned. GDx VCC shows fair discriminating ability in distinguishing normal from POAG and PACG eyes in Taiwan Chinese population.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>18344755</pmid><doi>10.1097/IJG.0b013e31814b9971</doi><tpages>6</tpages></addata></record> |
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| subjects | Area Under Curve Birefringence Cornea - physiology Cross-Sectional Studies Diagnostic Techniques, Ophthalmological Glaucoma, Angle-Closure - diagnosis Glaucoma, Open-Angle - diagnosis Humans Intraocular Pressure Lasers Middle Aged Nerve Fibers - pathology Optic Nerve Diseases - diagnosis Prospective Studies Retinal Ganglion Cells - pathology ROC Curve Sensitivity and Specificity Visual Field Tests - methods Visual Fields |
| title | Comparing Glaucomatous Optic Neuropathy in Primary Open Angle and Primary Angle Closure Glaucoma Eyes by Scanning Laser Polarimetry-Variable Corneal Compensation |
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