Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5

Activation of the proapoptotic receptor death receptor5 (DR5) in various cancer cells triggers programmed cell death through the extrinsic pathway. We have generated a fully human monoclonal antibody (Apomab) that induces tumor cell apoptosis through DR5 and investigated the structural features of i...

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Veröffentlicht in:	Cell death and differentiation 2008-04, Vol.15 (4), p.751-761
Hauptverfasser:	Adams, C, Totpal, K, Lawrence, D, Marsters, S, Pitti, R, Yee, S, Ross, S, Deforge, L, Koeppen, H, Sagolla, M, Compaan, D, Lowman, H, Hymowitz, S, Ashkenazi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacology Antibody Affinity Antibody Specificity Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Apoptosis - drug effects Binding Sites, Antibody Biochemistry Biomedical and Life Sciences Cancer therapies Caspase 8 - metabolism Cell Biology Cell Cycle Analysis Cell death Cell Line, Tumor Chemotherapy Crystallography, X-Ray Dose-Response Relationship, Drug Epitope Mapping Fas-Associated Death Domain Protein - metabolism Female Humans Life Sciences Ligands Mice Mice, Nude Models, Molecular Monoclonal antibodies Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Oncology original-paper Protein Binding Protein Conformation Receptor Aggregation - drug effects Receptors, TNF-Related Apoptosis-Inducing Ligand - agonists Receptors, TNF-Related Apoptosis-Inducing Ligand - chemistry Receptors, TNF-Related Apoptosis-Inducing Ligand - immunology Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Signal Transduction - drug effects Stem Cells Time Factors Tumor necrosis factor-TNF Tumors Xenograft Model Antitumor Assays
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