Ketamine gargle for attenuating postoperative sore throat
Tracheal intubation is a foremost cause of trauma to the airway mucosa, resulting in postoperative sore throat (POST) with reported incidences of 21–65%. We compared the effectiveness of ketamine gargles with placebo in preventing POST after endotracheal intubation. Forty‐six, ASA I–II, patients und...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 2008-04, Vol.100 (4), p.490-493 |
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| creator | Canbay, O. Celebi, N. Sahin, A. Celiker, V. Ozgen, S. Aypar, U. |
| description | Tracheal intubation is a foremost cause of trauma to the airway mucosa, resulting in postoperative sore throat (POST) with reported incidences of 21–65%. We compared the effectiveness of ketamine gargles with placebo in preventing POST after endotracheal intubation.
Forty‐six, ASA I–II, patients undergoing elective surgery for septorhinoplasty under general anaesthesia were enrolled in this prospective, randomized, placebo-controlled, single-blind study. Patients were randomly allocated into two groups of 23 subjects each: Group C, saline 30 ml; Group K, ketamine 40 mg in saline 30 ml. Patients were asked to gargle this mixture for 30 s, 5 min before induction of anaesthesia. POST was graded at 0, 2, 4, and 24 h after operation on a four-point scale (0–3).
POST occurred more frequently in Group C, when compared with Group K, at 0, 2, and 24 h and significantly more patients suffered severe POST in Group C at 4 and 24 h compared with Group K (P |
| doi_str_mv | 10.1093/bja/aen023 |
| format | Article |
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Forty‐six, ASA I–II, patients undergoing elective surgery for septorhinoplasty under general anaesthesia were enrolled in this prospective, randomized, placebo-controlled, single-blind study. Patients were randomly allocated into two groups of 23 subjects each: Group C, saline 30 ml; Group K, ketamine 40 mg in saline 30 ml. Patients were asked to gargle this mixture for 30 s, 5 min before induction of anaesthesia. POST was graded at 0, 2, 4, and 24 h after operation on a four-point scale (0–3).
POST occurred more frequently in Group C, when compared with Group K, at 0, 2, and 24 h and significantly more patients suffered severe POST in Group C at 4 and 24 h compared with Group K (P<0.05).
Ketamine gargle significantly reduced the incidence and severity of POST.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/aen023</identifier><identifier>PMID: 18310675</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; analgesic techniques ; analgesic techniques, topical ; Anesthesia ; Anesthesia, General ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; complications ; complications, intubation tracheal ; complications, sore throat ; Excitatory Amino Acid Antagonists - administration & dosage ; Excitatory Amino Acid Antagonists - therapeutic use ; Female ; Humans ; intubation tracheal ; Intubation, Intratracheal - adverse effects ; ketamine ; Ketamine - administration & dosage ; Ketamine - therapeutic use ; Male ; Medical sciences ; Mouthwashes ; pharmacology ; pharmacology, ketamine ; Pharyngitis - etiology ; Pharyngitis - prevention & control ; Postoperative Complications - prevention & control ; Prospective Studies ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Rhinoplasty ; Severity of Illness Index ; Single-Blind Method ; sore throat ; topical</subject><ispartof>British journal of anaesthesia : BJA, 2008-04, Vol.100 (4), p.490-493</ispartof><rights>2008 British Journal of Anaesthesia</rights><rights>The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org 2008</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Apr 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-eb8b4eb3602bfe4482b23c600f5d4332f85f237b61523bf2a683413a52bee7e13</citedby><cites>FETCH-LOGICAL-c491t-eb8b4eb3602bfe4482b23c600f5d4332f85f237b61523bf2a683413a52bee7e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20222779$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18310675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Canbay, O.</creatorcontrib><creatorcontrib>Celebi, N.</creatorcontrib><creatorcontrib>Sahin, A.</creatorcontrib><creatorcontrib>Celiker, V.</creatorcontrib><creatorcontrib>Ozgen, S.</creatorcontrib><creatorcontrib>Aypar, U.</creatorcontrib><title>Ketamine gargle for attenuating postoperative sore throat</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><description>Tracheal intubation is a foremost cause of trauma to the airway mucosa, resulting in postoperative sore throat (POST) with reported incidences of 21–65%. We compared the effectiveness of ketamine gargles with placebo in preventing POST after endotracheal intubation.
Forty‐six, ASA I–II, patients undergoing elective surgery for septorhinoplasty under general anaesthesia were enrolled in this prospective, randomized, placebo-controlled, single-blind study. Patients were randomly allocated into two groups of 23 subjects each: Group C, saline 30 ml; Group K, ketamine 40 mg in saline 30 ml. Patients were asked to gargle this mixture for 30 s, 5 min before induction of anaesthesia. POST was graded at 0, 2, 4, and 24 h after operation on a four-point scale (0–3).
POST occurred more frequently in Group C, when compared with Group K, at 0, 2, and 24 h and significantly more patients suffered severe POST in Group C at 4 and 24 h compared with Group K (P<0.05).
Ketamine gargle significantly reduced the incidence and severity of POST.</description><subject>Adolescent</subject><subject>Adult</subject><subject>analgesic techniques</subject><subject>analgesic techniques, topical</subject><subject>Anesthesia</subject><subject>Anesthesia, General</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>complications</subject><subject>complications, intubation tracheal</subject><subject>complications, sore throat</subject><subject>Excitatory Amino Acid Antagonists - administration & dosage</subject><subject>Excitatory Amino Acid Antagonists - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>intubation tracheal</subject><subject>Intubation, Intratracheal - adverse effects</subject><subject>ketamine</subject><subject>Ketamine - administration & dosage</subject><subject>Ketamine - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mouthwashes</subject><subject>pharmacology</subject><subject>pharmacology, ketamine</subject><subject>Pharyngitis - etiology</subject><subject>Pharyngitis - prevention & control</subject><subject>Postoperative Complications - prevention & control</subject><subject>Prospective Studies</subject><subject>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</subject><subject>Rhinoplasty</subject><subject>Severity of Illness Index</subject><subject>Single-Blind Method</subject><subject>sore throat</subject><subject>topical</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90d9rFDEQB_Agij2rL_4Bsgj6IKzNz032UQ610ooPVTj6EpLc5My5t9km2aL_vZE9WhDxaRj4MDN8B6HnBL8luGdndm_ODIyYsgdoRbgkbScleYhWGGPZ4p7QE_Qk5z3GRNJePEYnRDGCOylWqL-AYg5hhGZn0m6AxsfUmFJgnE0J466ZYi5xglS7W2hyTNCU7yma8hQ98mbI8OxYT9G3D--_rs_byy8fP63fXbaO96S0YJXlYFmHqfXAuaKWMtdh7MWWM0a9Ep4yaTsiKLOemk4xTpgR1AJIIOwUvV7mTinezJCLPoTsYBjMCHHOWmKOsRKiwpd_wX2c01hv06SXSqmOqYreLMilmHMCr6cUDib90gTrP2nqmqZe0qz4xXHibA-wvafH-Cp4dQQmOzP4ZEYX8p2jmFIqZX_v4jz9f2G7uJAL_LyTJv3QnWRS6PPNtd5cXF2trzdr_bl6vnioD7gNkHR2AUYH25DAFb2N4V9rfgN4QKqt</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Canbay, O.</creator><creator>Celebi, N.</creator><creator>Sahin, A.</creator><creator>Celiker, V.</creator><creator>Ozgen, S.</creator><creator>Aypar, U.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Ketamine gargle for attenuating postoperative sore throat</title><author>Canbay, O. ; Celebi, N. ; Sahin, A. ; Celiker, V. ; Ozgen, S. ; Aypar, U.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-eb8b4eb3602bfe4482b23c600f5d4332f85f237b61523bf2a683413a52bee7e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>analgesic techniques</topic><topic>analgesic techniques, topical</topic><topic>Anesthesia</topic><topic>Anesthesia, General</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>complications</topic><topic>complications, intubation tracheal</topic><topic>complications, sore throat</topic><topic>Excitatory Amino Acid Antagonists - administration & dosage</topic><topic>Excitatory Amino Acid Antagonists - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>intubation tracheal</topic><topic>Intubation, Intratracheal - adverse effects</topic><topic>ketamine</topic><topic>Ketamine - administration & dosage</topic><topic>Ketamine - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mouthwashes</topic><topic>pharmacology</topic><topic>pharmacology, ketamine</topic><topic>Pharyngitis - etiology</topic><topic>Pharyngitis - prevention & control</topic><topic>Postoperative Complications - prevention & control</topic><topic>Prospective Studies</topic><topic>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</topic><topic>Rhinoplasty</topic><topic>Severity of Illness Index</topic><topic>Single-Blind Method</topic><topic>sore throat</topic><topic>topical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Canbay, O.</creatorcontrib><creatorcontrib>Celebi, N.</creatorcontrib><creatorcontrib>Sahin, A.</creatorcontrib><creatorcontrib>Celiker, V.</creatorcontrib><creatorcontrib>Ozgen, S.</creatorcontrib><creatorcontrib>Aypar, U.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Canbay, O.</au><au>Celebi, N.</au><au>Sahin, A.</au><au>Celiker, V.</au><au>Ozgen, S.</au><au>Aypar, U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ketamine gargle for attenuating postoperative sore throat</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>100</volume><issue>4</issue><spage>490</spage><epage>493</epage><pages>490-493</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>Tracheal intubation is a foremost cause of trauma to the airway mucosa, resulting in postoperative sore throat (POST) with reported incidences of 21–65%. We compared the effectiveness of ketamine gargles with placebo in preventing POST after endotracheal intubation.
Forty‐six, ASA I–II, patients undergoing elective surgery for septorhinoplasty under general anaesthesia were enrolled in this prospective, randomized, placebo-controlled, single-blind study. Patients were randomly allocated into two groups of 23 subjects each: Group C, saline 30 ml; Group K, ketamine 40 mg in saline 30 ml. Patients were asked to gargle this mixture for 30 s, 5 min before induction of anaesthesia. POST was graded at 0, 2, 4, and 24 h after operation on a four-point scale (0–3).
POST occurred more frequently in Group C, when compared with Group K, at 0, 2, and 24 h and significantly more patients suffered severe POST in Group C at 4 and 24 h compared with Group K (P<0.05).
Ketamine gargle significantly reduced the incidence and severity of POST.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18310675</pmid><doi>10.1093/bja/aen023</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult analgesic techniques analgesic techniques, topical Anesthesia Anesthesia, General Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences complications complications, intubation tracheal complications, sore throat Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - therapeutic use Female Humans intubation tracheal Intubation, Intratracheal - adverse effects ketamine Ketamine - administration & dosage Ketamine - therapeutic use Male Medical sciences Mouthwashes pharmacology pharmacology, ketamine Pharyngitis - etiology Pharyngitis - prevention & control Postoperative Complications - prevention & control Prospective Studies Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Rhinoplasty Severity of Illness Index Single-Blind Method sore throat topical |
| title | Ketamine gargle for attenuating postoperative sore throat |
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