Plasmodium falciparum: Erythrocytic stages die by autophagic-like cell death under drug pressure

It has been reported that an apoptotic cell death process can occur with protozoans, but no consensus on Plasmodium susceptibility to apoptosis was reached till now. Thus, we evaluated if Plasmodium falciparum blood forms undergo apoptosis after in vitro pressure with chloroquine, S-nitroso- N-acety...

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Veröffentlicht in:	Experimental parasitology 2008-04, Vol.118 (4), p.478-486
Hauptverfasser:	Totino, Paulo Renato Rivas, Daniel-Ribeiro, Cláudio Tadeu, Corte-Real, Suzana, Ferreira-da-Cruz, Maria de Fátima
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarial drug Antimalarials - pharmacology Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Biological and medical sciences Caspase Inhibitors Cells, Cultured Chloroquine - pharmacology CQ, chloroquine DNA Fragmentation Erythrocytes - parasitology Flow Cytometry Fluorescent Dyes Fundamental and applied biological sciences. Psychology Humans In Situ Nick-End Labeling Life cycle. Host-agent relationship. Pathogenesis Malaria Membrane Potentials - drug effects Microscopy, Electron, Transmission Nitric Oxide Donors - pharmacology P. falciparum PCD, programmed cell death Penicillamine - analogs & derivatives Penicillamine - pharmacology Plasmodium falciparum Plasmodium falciparum - cytology Plasmodium falciparum - drug effects Plasmodium falciparum - growth & development Plasmodium falciparum - ultrastructure Protozoa Rhodamine 123 SNAP, S-nitroso- N-acetyl-penicillamine Stau, staurosporine Staurosporine - pharmacology Z-VAD-fmk, N-CBZ-Val-Aal-Asp(O-Me) fluoromethyl ketone Δ Ψm, mitochondrial membrane potential
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