Ligand Binding Induces a Conformational Change in ifnar1 that Is Propagated to Its Membrane-Proximal Domain

The type I interferon (IFN) receptor plays a key role in innate immunity against viral and bacterial infections. Here, we show by intramolecular Förster resonance energy transfer spectroscopy that ligand binding induces substantial conformational changes in the ectodomain of ifnar1 (ifnar1-EC). Bind...

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Veröffentlicht in:	Journal of molecular biology 2008-03, Vol.377 (3), p.725-739
Hauptverfasser:	Strunk, Jennifer Julia, Gregor, Ingo, Becker, Yvonne, Li, Zongli, Gavutis, Martynas, Jaks, Eva, Lamken, Peter, Walz, Thomas, Enderlein, Jörg, Piehler, Jacob
Format:	Artikel
Sprache:	eng
Schlagworte:	conformational dynamics cytokine receptor Fluorescence Resonance Energy Transfer fluorescence spectroscopy Interferon-alpha - chemistry Interferon-alpha - metabolism Interferon-beta - chemistry Interferon-beta - metabolism Microscopy, Electron, Transmission Protein Binding Protein Conformation Protein Subunits - chemistry Protein Subunits - metabolism protein–protein interaction Receptor, Interferon alpha-beta - chemistry Receptor, Interferon alpha-beta - metabolism Temperature type I interferon receptor
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