Synthesis, DNA interaction and cytotoxicity studies of cis-{[1, 2-bis(aminomethyl)cyclohexane]dihalo}platinum(II) complexes

A series of platinum compounds with an analogue structure to cisplatin have been synthesized and their biological activity against HL-60 cancer cell line has been studied. The interaction with DNA was evaluated by circular dichroism (CD), electrophoresis and atomic force microscopy (AFM) techniques...

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Veröffentlicht in:	Journal of inorganic biochemistry 2008-04, Vol.102 (4), p.973-987
Hauptverfasser:	Mier-Vinué, Jordi de, Lorenzo, Julia, Montaña, Ángel M., Moreno, Virtudes, Avilés, Francesc X.
Format:	Artikel
Sprache:	eng
Schlagworte:	Atomic force microscopy Circular dichroism DNA - chemistry DNA - drug effects Electrophoresis HL-60 cell line Magnetic Resonance Spectroscopy Mass Spectrometry - methods Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Platinum(II) complexes Spectrophotometry, Infrared
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