Coated‐platelets in ischemic stroke: differences between lacunar and cortical stroke

Background: Coated‐platelets are a subset of platelets with procoagulant potential observed upon dual agonist stimulation with collagen and thrombin. Objective: The goal was to investigate if coated‐platelet production differs between patients with lacunar ischemic stroke and non‐lacunar (cortical) ischemic stroke as compared with controls. Patients and methods: Blood samples from 60 patients with ischemic stroke (20 lacunar and 40 cortical) and 70 controls were analyzed for coated‐platelet production. Results: Coated‐platelet production was significantly lower in patients with lacunar stroke (21.8 ± 11.4%, mean ± 1 SD) as compared with either controls (31.6 ± 13.2%, P = 0.008) or patients with cortical stroke (39.4 ± 12.7%, P