Aspirin Resistance in Children with Heart Disease at Risk for Thromboembolism: Prevalence and Possible Mechanisms

Aspirin is used to prevent thromboembolism in children with heart disease without evidence supporting its efficacy. Studies in adults report a 5%–51% prevalence of aspirin resistance, yet the mechanisms involved are poorly understood. Our aims were to determine its prevalence in these children and t...

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Veröffentlicht in:	Pediatric cardiology 2008-03, Vol.29 (2), p.285-291
Hauptverfasser:	Heistein, Lisa C., Scott, William A., Zellers, Thomas M., Fixler, David E., Ramaciotti, Claudio, Journeycake, Janna M., Lemler, Matthew S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Aspirin - administration & dosage Aspirin - therapeutic use Blood Platelets - drug effects Blood Platelets - physiology Cardiac Surgery Cardiology Child Child, Preschool Dose-Response Relationship, Drug Drug Resistance - physiology Female Follow-Up Studies Heart Defects, Congenital - complications Heart Defects, Congenital - metabolism Humans Infant Male Medicine Medicine & Public Health Original Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - therapeutic use Prevalence Prognosis Retrospective Studies Risk Factors Texas - epidemiology Thromboembolism - epidemiology Thromboembolism - etiology Thromboembolism - prevention & control Thromboxane B2 - analogs & derivatives Thromboxane B2 - urine Vascular Surgery
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